A5000729318- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Inflammatory Biomarkers in Disease Prognosis
- Liver Diseases and Immunity
- Drug Transport and Resistance Mechanisms
- Liver Disease and Transplantation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Cardiovascular Function and Risk Factors
- Pancreatitis Pathology and Treatment
- Vitamin D Research Studies
- Diabetes Treatment and Management
- Diabetes Management and Research
- Heart Failure Treatment and Management
- Chronic Kidney Disease and Diabetes
- Hormonal Regulation and Hypertension
- Lipid metabolism and disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
Medical University of Graz
2013-2023
Graz University Hospital
2020
Medical University of Vienna
2015-2019
University of Graz
2007-2016
Ludwig Boltzmann Institute Applied Diagnostics
2016
Wilhelminen Hospital
2015
Kantonsspital Aarau
2015
Policlinico S.Orsola-Malpighi
2015
Cardiovascular Institute of the South
2012
Centre for Addiction and Mental Health
2012
The aim was to study the prognostic value of plasma ceramides (Cer) as cardiovascular death (CV death) markers in three independent coronary artery disease (CAD) cohorts.Corogene is a prospective Finnish cohort including stable CAD patients (n = 160). Multiple lipid biomarkers and C-reactive protein were measured addition Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0), Cer(d18:1/24:1). Subsequently, association between high-risk CV mortality investigated Special Program University...
The neutrophil-lymphocyte ratio (NLR) has been proposed as an indicator of systemic inflammatory response. Previous findings from small-scale studies revealed conflicting results about its independent prognostic significance with regard to different clinical end points in pancreatic cancer (PC) patients. Therefore, the aim our study was external validation NLR a large cohort PC patients.Data 371 consecutive patients, treated between 2004 and 2010 at single centre, were evaluated...
Low vitamin D status is linked to increased mortality and morbidity in patients who are critically ill. It unknown if this association causal.To investigate whether a D3 treatment regimen intended restore maintain normal over 6 months of health benefit for ICUs.A randomized double-blind, placebo-controlled, single-center trial, conducted from May 2010 through September 2012 at 5 ICUs that included medical surgical population 492 ill adult white with deficiency (≤20 ng/mL) assigned receive...
Inflammation has a critical role in the pathogenesis and progression of cancer. The lymphocyte to monocyte ratio (LMR) could be shown prognostic haematologic neoplasia. In this study, we analysed LMR with clinical outcome stage II III colon cancer patients. Three hundred seventy-two patients were included retrospective study. Kaplan–Meier curves multivariate Cox-regression analyses calculated for time recurrence (TTR) overall survival (OS). Including all patients, elevated preoperative was...
The elevation of the platelet-to-lymphocyte ratio (PLR), an easily applicable blood test based on platelet and lymphocyte counts has been associated with poor prognosis in patients different types cancer. present study was aimed to investigate prognostic significance preoperative PLR a large cohort breast cancer patients. Data from 793 consecutive non-metastatic patients, treated between 1999 2004, were evaluated retrospectively. optimal cutoff values for calculated using receiver operating...
Bile acids (BAs) are major regulators of hepatic BA and lipid metabolism but their mechanisms action in non-alcoholic fatty liver disease (NAFLD) still poorly understood. Here we aimed to explore the molecular biochemical ursodeoxycholic acid (UDCA) modulating cross-talk between visceral white adipose tissue (vWAT) regarding cholesterol acid/lipid partitioning morbidly obese NAFLD patients.In this randomized controlled pharmacodynamic study, analyzed serum, vWAT samples from 40 well-matched...
Functional impairment of HDL may contribute to the excess cardiovascular mortality experienced by patients with renal disease, but effect advanced disease on composition and function is not well understood. Here, we used mass spectrometry biochemical analyses study alterations in proteome lipid isolated from maintenance hemodialysis. We identified a significant increase amount acute phase protein serum amyloid A1, albumin, lipoprotein-associated phospholipase A2, apoC-III composing uremic...
The neutrophil–lymphocyte ratio (NLR) has been proposed as an indicator of systemic inflammatory response. Several studies suggest a negative impact increased NLR for patient's survival in different types cancer. However, previous findings from small-scale revealed conflicting results about its prognostic significance with regard to clinical end points non-metastatic renal cell carcinoma (RCC) patients. Therefore, the aim our study was validation large cohort RCC Data 678 consecutive clear...
Inflammation has a critical role in the pathogenesis and progression of cancer. Recently, derived neutrophil to lymphocyte ratio (absolute count neutrophils divided by absolute white cell minus neutrophils; dNLR) been shown influence clinical outcome various cancer entities. In this study, we analysed dNLR with stage II III colon patients. Three-hundred seventy-two patients were included retrospective study. Kaplan–Meier curves multivariate Cox proportion analyses calculated for time...
Cardiac troponins are often elevated in patients with skeletal muscle disease who have no evidence of cardiac disease. The goal this study was to characterize troponin concentrations myopathies and derive insights regarding the source T measurements. (cTnT) I (cTnI) were determined by using high sensitivity assays 74 hereditary acquired myopathies. Patients underwent comprehensive evaluation, including 12-lead electrocardiogram, 24-h magnetic resonance imaging, coronary artery computed...
There is growing evidence that adiponectin, the most abundant adipocytokine of adipose tissue cells, plays a crucial role in advanced atherosclerosis.The objective study was to evaluate adiponectin early atherosclerosis.One hundred forty obese juveniles (mean age, 13.5 +/- 4.4 yr) and 100 age-matched, healthy, normal-weight controls from STYrian Juvenile Obesity Study were investigated. We measured adipocytokines, inflammatory biomarkers, parameters insulin resistance, lipid subfractions....
Recent evidence indicates that the host inflammatory response has an important role in tumour progression. Elevated C-reactive protein (CRP) levels have been previously associated with poor prognosis several cancer types including small-scale studies pancreatic (PC) patients. The purpose of present study was to validate prognostic impact plasma CRP at date diagnosis on cancer-specific survival (CSS) a large cohort PC Data from 474 consecutive patients adenocarcinoma pancreas, treated between...
Abstract Introduction Vitamin D deficiency is encountered frequently in critically ill patients and might be harmful. Current nutrition guidelines recommend very low vitamin doses. The objective of this trial was to evaluate the safety efficacy a single oral high-dose D3 supplementation an intensive care setting over one-week observation period. Methods This randomized, double-blind, placebo-controlled pilot study medical ICU at tertiary university center Graz, Austria. Twenty-five (mean age...
Increasing evidence indicates the involvement of inflammation and coagulation in cancer progression metastases. Inflammatory biomarkers hold great promise for improving predictive ability existing prognostic tools patients. In present study, we investigated several inflammatory indices with regard to their relevance predicting clinical outcome soft tissue sarcoma (STS) Three hundred forty STS patients were divided into a training set (n = 170) validation 170). Besides well-established...
Vitamin D plays a key role in immune function. Deficiency may aggravate the incidence and outcome of infectious complications critically ill patients. We aimed to evaluate prevalence vitamin deficiency correlation between serum 25-hydroxyvitamin (25(OH) D) hospital mortality, sepsis mortality blood culture positivity. In single-center retrospective observational study at tertiary care center Graz, Austria, 655 surgical nonsurgical patients with available 25(OH) levels hospitalized September...
Recent data indicate that tumour microenvironment, which is influenced by inflammatory cells, has a crucial role in cancer progression and clinical outcome of patients. In the present study, we investigated prognostic relevance preoperative neutrophil/lymphocyte (N/L) ratio on time to recurrence (TTR) overall survival (OS) soft-tissue sarcoma (STS) patients who underwent curative surgical resection.In all, 260 STS were included this retrospective study. Kaplan-Meier curves multivariate Cox...
Aminotransaminases, which are strongly involved in cellular metabolism and cancer cell turnover, represent easily measureable, potential blood based biomarkers. We evaluated the prognostic value of preoperatively assessed AST/ALT (De Ritis) ratio on clinically meaningful end points a large European cohort patients with nonmetastatic renal carcinoma.We retrospectively clinicopathological data 698 carcinoma operated between 2005 2013 at single tertiary academic center. The was analyzed using...
Summary Background and objectives Patients undergoing maintenance hemodialysis are at high cardiovascular risk. Lowering LDL-cholesterol with statins reduces the incidence rate of events in patients chronic kidney disease. In contrast, two randomized, prospective, placebo-controlled trials have been completed that showed no significant effects on outcomes. Design, setting, participants, & measurements A post hoc analysis was conducted 4D (Die Deutsche Diabetes Dialyze) study to...
Abstract Background Previous studies suggest that chronic liver disease may be related to vitamin D deficiency. It is, however, not known whether 25( OH ) levels are associated with incident hepatic decompensation and mortality in failure. Aims We aimed evaluate serum C hild– P ugh ( CP score, model for end‐stage MELD occurrence of decompensation, survival patients cirrhosis. Methods enrolled 75 consecutive cirrhotic admitted our outpatient clinic (32% females; age: 58 ± 11 years; aetiology...
In recent years, plasma fibrinogen has been ascribed an important role in the pathophysiology of tumour cell invasion and metastases. A relatively small-scale study indicated that levels may serve as a prognostic factor for predicting clinical outcomes non-metastatic renal carcinoma (RCC) patients.Data from 994 consecutive RCC patients, operated between 2000 2010 at single, tertiary academic centre, were evaluated. Analyses performed one day before surgical interventions. Patients...