A5101995033- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Renin-Angiotensin System Studies
- Immune Cell Function and Interaction
- Apelin-related biomedical research
- RNA Research and Splicing
- interferon and immune responses
- Transplantation: Methods and Outcomes
- Receptor Mechanisms and Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- RNA modifications and cancer
- Long-Term Effects of COVID-19
- Immune Response and Inflammation
- Renal and Vascular Pathologies
- Hormonal Regulation and Hypertension
- Neonatal Respiratory Health Research
- Cardiac Arrest and Resuscitation
- Biomedical Research and Pathophysiology
- Nuclear Receptors and Signaling
- Drug Transport and Resistance Mechanisms
- Cardiac Fibrosis and Remodeling
- Neuropeptides and Animal Physiology
- Adenosine and Purinergic Signaling
National Institute of Biomedical Innovation, Health and Nutrition
2017-2024
Fukuoka Tokushukai Hospital
2024
Nozaki Tokushukai Hospital
2024
Biology of Infection
2023
Akita University
2009-2022
NTL Institute for Applied Behavioral Science
2022
Osaka University
1967-2021
Protein Research Foundation
1967-2021
Niigata City General Hospital
2002-2015
St. Michael's Hospital
2001-2012
During several months of 2003, a newly identified illness termed severe acute respiratory syndrome (SARS) spread rapidly through the world1,2,3. A new coronavirus (SARS-CoV) was as SARS pathogen4,5,6,7, which triggered pneumonia and acute, often lethal, lung failure8. Moreover, among infected individuals influenza such Spanish flu9,10 emergence disease viruses11,12 have caused high lethality resulting from failure13. In cell lines, angiotensin-converting enzyme 2 (ACE2) has been potential...
Recent clinical trials have demonstrated a decrease in multiple organ dysfunction syndrome (MODS) and mortality patients with acute respiratory distress (ARDS) treated protective ventilatory strategy.To examine the hypothesis that an injurious strategy may lead to end-organ epithelial cell apoptosis dysfunction.In vivo animals: 24 rabbits acid-aspiration lung injury were ventilated or noninjurious strategies. In vitro: rabbit cells exposed plasma from studies. human: samples included...
Patients who developed acute respiratory distress syndrome (ARDS) after infection with severe viruses (e.g., syndrome-coronavirus, H5N1 avian influenza virus), exhibited unusually high levels of CXCL10, which belongs to the non-ELR (glutamic-leucine-arginine) CXC chemokine superfamily. CXCL10 may not be a bystander virus but directly contribute pathogenesis neutrophil-mediated, excessive pulmonary inflammation.We investigated contribution and its receptor CXCR3 axis ARDS nonviral viral...
Chemotherapy is not effective for hepatocellular carcinoma (HCC). HMG-CoA redutase inhibitors have cytostatic activity cancer cells, but their clinical usefulness unknown. To investigate whether pravastatin, a potent reductase inhibitor, prolongs survival in patients with advanced HCC, this randomized controlled trial was conducted between February 1990 and 1998 at Osaka University Hospital. 91 consecutive <71 years old (mean age 62) unresectable HCC were enroled study. 8 withdrawn because...
Apelin constitutes a novel endogenous peptide system suggested to be involved in broad range of physiological functions, including cardiovascular function, heart development, control fluid homeostasis, and obesity. is also catalytic substrate for angiotensin-converting enzyme 2, the key severe acute respiratory syndrome receptor. The vivo role still elusive. Here we report generation gene–targeted mice. mutant mice are viable fertile, appear healthy, exhibit normal body weight, water food...
Angiotensin converting enzyme 2 (ACE2) is a negative regulator of the renin-angiotensin system (RAS), catalyzing conversion II to 1-7. Apelin second catalytic substrate for ACE2 and functions as an inotropic cardioprotective peptide. While antagonistic relationship between RAS apelin has been proposed, such functional interplay remains elusive. Here we found that was downregulated in apelin-deficient mice. Pharmacological or genetic inhibition angiotensin type 1 receptor (AT1R) rescued...
Exposure of liver microsomes to high concentrations neutral salts resulted in the conversion microsomal hemoprotein, P-450, a modified form called P-420. The efficiency various causing obeyed order known as Hofmeister’s lyotropic series ions, i.e. SCN− > I− Br− Cl− SO4 −−, CH3COO− for anions, and Li+ K+, Na+ cations. induced by proceeded more rapidly dithionite-treated microsomes, which hemoprotein was kept reduced, than aerobic microsomes. Even absence, added took place some extent when pH...
Elabela/Toddler/Apela (ELA) has been identified as a novel endogenous peptide ligand for APJ/Apelin receptor/Aplnr. ELA plays crucial role in early cardiac development of zebrafish well maintenance self-renewal human embryonic stem cells. Apelin was the first APJ ligand, and exerts positive inotropic heart effects regulates renin-angiotensin system. The aim this study to investigate biological cardiovascular system.Continuous infusion significantly suppressed pressure overload-induced...
This study compared pathophysiological and biochemical indexes of acute lung injury in a saline-lavaged rabbit model with different ventilatory strategies: control group consisting moderate tidal volume (V(T)) (10-12 ml/kg) low positive end-expiratory pressure (PEEP) (4-5 cmH(2)O); three protective groups: 1) V(T) (5-6 high PEEP, 2-3 cmH(2)O greater than the lower inflection point; 2) ml/kg), PEEP (8-10 3) high-frequency oscillatory ventilation (HFOV). The strategy using > point resulted...
To evaluate the role of tumor necrosis factor (TNF)-α in pathogenesis ventilator-induced lung injury, we 1) measured TNF-α production caused by conventional mechanical ventilation (CMV) and 2) evaluated protective effect anti-TNF-α antibody (Ab) saline-lavaged rabbit lungs. After they received saline lavage, rabbits were intratracheally instilled with 1 mg/kg polyclonal Ab high-dose group ( n = 6), 0.2 low-dose serum IgG fraction control 7). Animals then underwent CMV for 4 h. Levels lavage...
Journal Article Identification of Virulence-Associated Antigens and Plasmids in Rhodococcus equi from Patients with AIDS Get access Shinji Takai, Takai Reprints or correspondence: Dr. Dept. Animal Hygiene, School Veterinary Medicine Sciences, Kitasato University, Towada, Aomori 034, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Yumiko Imai, Imai Nariaki Fukunaga, Fukunaga Yoshiyuki Uchida, Uchida Kei Kamisawa, Kamisawa Yukako Sasaki, Sasaki Shiro...