A5054263812- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Global Health Care Issues
- Climate Change and Health Impacts
- Advanced Polymer Synthesis and Characterization
- Electronic Health Records Systems
- RNA Interference and Gene Delivery
- Photoreceptor and optogenetics research
- Advanced biosensing and bioanalysis techniques
- Geography and Environmental Studies
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Photopolymerization techniques and applications
- Receptor Mechanisms and Signaling
- Cleft Lip and Palate Research
- Air Quality and Health Impacts
- Insurance, Mortality, Demography, Risk Management
- DNA and Nucleic Acid Chemistry
- Craniofacial Disorders and Treatments
- Microbial Metabolism and Applications
- Medical Coding and Health Information
- Oil Spill Detection and Mitigation
- Water resources management and optimization
- Nicotinic Acetylcholine Receptors Study
- Plant biochemistry and biosynthesis
University of Nicosia
2015-2024
Universidade Federal do Rio de Janeiro
1993-2010
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
2009
University of Cyprus
2000-2003
Osaka University
1994-2001
Kyushu University
2001
University of Manchester
2000
Harvard University
1998
University of California, Berkeley
1975
About 300 carcinogens and non-carcinogens of a wide variety chemical types have been tested for mutagenicity in the simple Salmonella/microsome test. The test uses bacteria as sensitive indicators DNA damage, mammalian liver extracts metabolic conversion to their active mutagenic forms. Quantitative data from linear dose-response curves are presented: potency varies over 10(6)-fold range. There is high correlation between carcinogenicity mutagenicity: 90% (156/174) despite severe limitations...
We have previously described a sensitive bacterial test for dectecting carcinogens as mutagens. detecting show here that 89% (150/169) of commercial oxidative-type (hydrogen peroxide) hair dye formulations are mutagenic in this test. Of the 18 components these dyes, nine various degrees mutagenicity:2,4-diaminoanisole, 4-nitro-o-phenylenediamine, 2-nitro-p-phenylenediamine, 2,5-diaminoanisole, 2-amino-5-nitrophenol, m-phenylenediamine, o-phenylenediamine, 2-amino-4-nitrophenol, and...
A method is described for concentrating mutagens/carcinogens from human urine about 200-fold subsequent assay in the Salmonella/mammalian microsome mutagenicity test. The also applicable other aqueous liquids and vitro tests mutagens/carcinogens. (up to 500 ml) put through a column with 1.5-cm3 bed volume of XAD-2 (styrene-divinylbenzene polymer) adsorbed material then eluted few milliliters acetone. acetone taken dryness residue dissolved dimethyl sulfoxide. This concentrate that assayed...
Chemotherapy is not effective for hepatocellular carcinoma (HCC). HMG-CoA redutase inhibitors have cytostatic activity cancer cells, but their clinical usefulness unknown. To investigate whether pravastatin, a potent reductase inhibitor, prolongs survival in patients with advanced HCC, this randomized controlled trial was conducted between February 1990 and 1998 at Osaka University Hospital. 91 consecutive <71 years old (mean age 62) unresectable HCC were enroled study. 8 withdrawn because...
Seven star polymers with degrees of polymerization (DPs) the arms from 10 to 100 and dimensions in nanometer range were prepared using sequential group transfer 2-(dimethylamino)ethyl methacrylate (DMAEMA, hydrophilic positively ionizable monomer) ethylene glycol dimethacrylate (hydrophobic neutral cross-linker). The characterized tetrahydrofuran by gel permeation chromatography static light scattering determine molecular weights weight-average number for each sample. varied 20 72. Aqueous...
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTCationic Amphiphilic Model Networks: Synthesis by Group Transfer Polymerization and Characterization of the Degree SwellingMartin R. Simmons, Edna N. Yamasaki, Costas S. PatrickiosView Author Information Department Chemical Engineering, University Manchester Institute Science Technology (UMIST), P.O. Box 88, M60 1QD, U.K., Natural Sciences, Cyprus, 20537, 1678 Nicosia, Cyprus Cite this: Macromolecules 2000, 33, 8, 3176–3179Publication Date (Web):March...
Abstract Investigation of the morphology ganglion cells in cat retina has shown that a remarkable reduction number dendritic spines and branches occurs during development alpha beta cell classes. To learn whether remodelling represents generalized mechanism mammalian retinal development, we have examined developing rat. The present study concentrated on type II cells, which retain great adult comprise large proportion population rat cells. reveal fine axonal processes, Lucifer yellow was...
Abstract In the present work, we have characterized maturation of GABAergic system in mammalian retina. Immunoreactivity for GABA, GAD (glutamic acid decarboxylase, EC 4.1.1.15) ‐65 and ‐67 adult rat retina was localized cells inner nuclear ganglion cell layers. This pattern established around postnatal day 8 included transient GABA GAD‐67 expression horizontal cells. activity very low at P1 P4, increasing after P8, reaching maximal by P21 decreasing to attain values P30. content...
Abstract Alcohol intake during pregnancy has a tremendous impact on the developing brain. Embryonic and early postnatal alcohol exposures have been investigated experimentally to elucidate fetal spectrum disorders' (FASD) milieu, new data emerged support devastating effect GABAergic system in adult nervous system. GABA is predominantly inhibitory neurotransmitter that development excites neurons orchestrates several developmental processes such as proliferation, migration, differentiation,...
Use of Integrated Health Information Systems (IHIS) for the provision healthcare services benefits both professionals and patients, while requiring continuous evaluation upgrading to fully support its role.The main purpose study was develop an framework hospitals utilizing IHIS, within three areas identified as Human factor, Technology Organization.The questionnaire consisted 43 questions, with 17 questions (related categories procedures, system quality satisfaction), 25 categories, safety...
We investigated short-term alterations in plasma interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor α (TNF-α) levels induced by interferon alfa (IFN-α) injection 18 patients with chronic hepatitis C. A single intramuscular of human recombinant IFN-α 2a (6 million units [MU]) significantly increased the IL-6 level 6 hours after ( P < .05). On other hand, did not affect TNF-α IL-lβ levels. Polymerase chain reaction (PCR) analysis showed accumulation gene transcripts...
Abstract Several mechanisms underlying ethanol action in GABAergic synapses have been proposed, one of these is on GABA release. Here, we report that ovo exposure to induces an increase release the embryonic chick retina. Eleven‐day‐old embryos (E11) received injection either phosphate buffer saline (PBS) or (10%, v/v, diluted PBS), and were allowed develop until E16. A single glutamate stimulus (2 mM) showed approximately a 40% E16 retinas when compared controls. The effect was dependent...
Cyprus experiences the highest level of water stress among European Union countries due to several interplaying factors such as rainfall variability and increasing demand. These instigate nation build dams on almost all rivers island satisfy requirements for drinking irrigation. Many studies have been primarily conducted assessing availability various uses, particularly supply However, there is still a gap/less explored area in terms better understanding changes surface over time. Thus, this...