A5015976846- Melanoma and MAPK Pathways
- Monoclonal and Polyclonal Antibodies Research
- NF-κB Signaling Pathways
- HER2/EGFR in Cancer Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Bone Metabolism and Diseases
- Bone health and treatments
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Cell death mechanisms and regulation
- Receptor Mechanisms and Signaling
- Immune Response and Inflammation
- FOXO transcription factor regulation
- Telomeres, Telomerase, and Senescence
- DNA Repair Mechanisms
- Calcium signaling and nucleotide metabolism
- Renal and related cancers
- Cell Adhesion Molecules Research
- Radiopharmaceutical Chemistry and Applications
- COVID-19 Clinical Research Studies
- Protein Kinase Regulation and GTPase Signaling
- Gastrointestinal Tumor Research and Treatment
- PARP inhibition in cancer therapy
- Pluripotent Stem Cells Research
Daiichi-Sankyo (Japan)
2016-2024
Institute of Molecular Biotechnology
2003-2023
Austrian Academy of Sciences
2002-2023
Daiichi Sankyo (Germany)
2019
Daiichi-Sankyo (South Korea)
2019
Shionogi (Japan)
2010
University of Toronto
2001-2006
Tokyo Medical and Dental University
2005-2006
Lunenfeld-Tanenbaum Research Institute
2006
Mount Sinai Hospital
2006
During several months of 2003, a newly identified illness termed severe acute respiratory syndrome (SARS) spread rapidly through the world1,2,3. A new coronavirus (SARS-CoV) was as SARS pathogen4,5,6,7, which triggered pneumonia and acute, often lethal, lung failure8. Moreover, among infected individuals influenza such Spanish flu9,10 emergence disease viruses11,12 have caused high lethality resulting from failure13. In cell lines, angiotensin-converting enzyme 2 (ACE2) has been potential...
Trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate with topoisomerase I inhibitor exatecan derivative (DX-8951 derivative, DXd), has been reported to exert potent antitumor effects in xenograft mouse models and clinical trials. In this study, the immune system-activating ability of DS-8201a was assessed. significantly suppressed tumor growth an immunocompetent model human HER2-expressing CT26.WT (CT26.WT-hHER2) cells. Cured mice rejected not only rechallenged...
Meiosis is a critical stage of gametogenesis in which alignment and synapsis chromosomal pairs occur, allowing for the recombination maternal paternal genomes. Here we show that FK506 binding protein (Fkbp6) localizes to meiotic chromosome cores regions homologous synapsis. Targeted inactivation Fkbp6 mice results aspermic males absence normal pachytene spermatocytes. Moreover, identified deletion exon 8 as causative mutation spontaneously male sterile / mutant rats. Loss abnormal pairing...
Cardiac and skeletal muscle critically depend on mitochondrial energy metabolism for their normal function. Recently, we showed that apoptosis-inducing factor (AIF), a protein implicated in programmed cell death, plays role respiration. However, the vivo consequences of AIF-regulated respiration resulting from loss-of-function mutation Aif are not known. Here, report tissue-specific deletion mouse. Mice which has been inactivated specifically cardiac exhibit impaired activity expression...
We have recently shown that genetic inactivation of phosphoinositide 3-kinase gamma (PI3Kgamma), the isoform linked to G-protein-coupled receptors, results in increased cardiac contractility with no effect on basal cell size. Signaling via beta-adrenergic receptors has been implicated hypertrophy and heart failure, suggesting PI3Kgamma might play a role pathogenesis disease.To determine for induced by cardiomyopathy, we infused isoproterenol, receptor agonist, into PI3Kgamma-deficient mice....
The concept of tumor surveillance implies that specific and nonspecific components the immune system eliminate tumors in early phase malignancy. Understanding biochemical mechanisms immunosurveillance is paramount significance because it might allow one to specifically modulate spontaneous antitumor activity. We report inactivation E3 ligase Casitas B cell lymphoma-b (Cbl-b) confers vivo rejection cells express human papilloma virus antigens. Moreover, cbl-b−/− mice develop significantly...
Ultraviolet (UV) irradiation stimulates stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), which is a member of the mitogen-activated (MAPK) superfamily and implicated in stress-induced apoptosis. UV also induces activation another MAPK member, extracellular signal-regulated (ERK), typically involved growth-signaling cascade. However, UV-induced signaling pathway leading to ERK activation, together with physiological role, has remained unknown. Here we examined molecular...
In neonatal cardiomyocytes, activation of the G(q)-coupled alpha(1)-adrenergic receptor (alpha(1)AR) induces hypertrophy by activating mitogen-activated protein kinases, including c-Jun NH(2)-terminal kinase (JNK). Here, we show that JNK is essential for alpha(1)AR-induced hypertrophy, in hypertrophic responses, such as reorganization actin cytoskeleton and increased synthesis, could be blocked expressing JNK-binding domain JNK-interacting protein-1, a specific inhibitor JNK. We also...
There are two types of neural stem cells (NSCs). Primitive NSCs [leukemia inhibitory factor (LIF) dependent but exogenous fibroblast growth (FGF) 2 independent] can be derived from mouse embryonic (ES) <i>in vitro</i> and day 5.5 (E5.5) to E7.5 epiblast E7.5–E8.5 neuroectoderm vivo</i>. Definitive (LIF independent FGF2 dependent) first appear in the E8.5 plate persist throughout life. give rise definitive NSCs. Loss gain functions were used study role vascular endothelial (VEGF)-A its...
Signal regulatory protein alpha (SIRPα) is an immune inhibitory receptor on myeloid cells including macrophages and dendritic cells, which binds to CD47, a ubiquitous self-associated molecule. SIRPα-CD47 interaction exploited by cancer suppress anti-tumor activity of therefore emerging as novel checkpoint for immunotherapy. In blood cancer, several blockers have shown encouraging monotherapy activity. However, the in solid tumors seems limited, suggesting need combination therapies fully...
Carma1 (also known as caspase recruitment domain [CARD]11, Bimp3) is a CARD-containing membrane-associated guanylate kinase family protein that plays an essential role in antigen receptor–induced nuclear factor κB activation. We investigated the of assembly signaling molecules at immune synapse using peptide-specific system. report for peptide-induced interleukin 2 and interferon γ production, but dispensable proliferation T cells. Recruitment distribution cell receptor, lymphocyte function...