A5034485670- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Hormonal and reproductive studies
- Diabetes and associated disorders
- Dermatology and Skin Diseases
- Autophagy in Disease and Therapy
- Pharmacology and Obesity Treatment
- Cell death mechanisms and regulation
- Cancer Immunotherapy and Biomarkers
- Sexual function and dysfunction studies
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Atherosclerosis and Cardiovascular Diseases
- Ubiquitin and proteasome pathways
- Monoclonal and Polyclonal Antibodies Research
- Immune responses and vaccinations
- Muscle metabolism and nutrition
- Allergic Rhinitis and Sensitization
- Pluripotent Stem Cells Research
- Erythrocyte Function and Pathophysiology
- Pharmacological Effects and Assays
Ontario Institute for Cancer Research
2003-2011
University of Toronto
2003-2011
University of Virginia
2006-2009
Carter Center
2006-2009
University Health Network
2004
Understanding the pathways that signal T cell tolerance versus activation is key to regulating immunity. Previous studies have linked CD28 and protein kinase C-theta (PKCtheta) as a potential signaling pathway influences activation. Therefore, we compared responses of cells deficient for PKCtheta in vivo vitro. Here, demonstrate absence leads induction anergy, with phenotype comparable CD28. Further experiments examined whether triggered other CD28-dependent responses. Our data show CD4...
Pharmacokinetic and efficacy data from a phase 3 testosterone nasal gel (TNG) study were stratified by baseline endogenous level in patients with deficiency. Total (TT), LH, FSH levels, as well erectile function, mood, lean body mass for each group compared. In subset of very low levels (<100 ng/dL), we investigated whether TNG is suitable treatment option.Patients deficiency (serum TT <300 ng/dL) treated months, followed safety extension periods 90 and/or 180 days. parameters calculated...
T cell apoptosis is a process necessary for central and peripheral tolerance. It ensures the proper removal of autoreactive cells during thymic development as well homeostasis downregulation immune responses against antigens in periphery. Thus it essential prevention autoimmunity. Apoptotic pathways can be triggered by intrinsic (mitochondria-based) extrinsic (receptor-based) stimuli. Both involve cascade proteolytic enzymes called caspases whose activation commits to death. In periphery,...
Natesto®, testosterone nasal gel (TNG) is an intranasal therapy (TTh) used to restore levels and improve symptoms of hypogonadism. Treatment requires application two (bid) or three (tid) times daily. The Satisfaction Questionnaire for Medication (TSQM) a Patient Preference Use (PPU) were obtain patient feedback on the use TNG compare experience with topical TTh.The study enrolled 24 TTh-naive (TThN) 93 TTh-experienced (TThE) hypogonadal men. lasted up 120 days, titration at day 90 determine...
Introduction: Natesto®, testosterone nasal gel (TNG), is a therapy (TTh) indicated for adult male hypogonadism.1 This study allowed titration decisions to be based on physicians’ assessment of patient symptoms.
 Methods: Hypogonadal males active topical (TThE) or naive any form (TThN) were treated with 22 mg TNG daily (11 twice daily) 90 days. Titration was determined by the physician at Day wherein dose increased 33 if symptoms not properly managed. Total (TT) levels collected and 120...
The Review of Diabetic Studies,2004,1,1,47-50.DOI:10.1900/RDS.2004.1.47Published:May 2004Type:Conference ReportAuthors:Matthew A Gronski Author(s) affiliations:Matthew A. University Health Network, Ontario Cancer Institute, Department Immunology, Toronto, Canada M5G 2M9, Abstract:The bi-annual FASEB autoimmunity conference organized last year by Betty Diamond and Stephen Miller brought together some 150 delegates studying various aspects autoimmune diseases such as lupus, rheumatoid...
Abstract Calcium plays a key role as second messenger in many cell types, but for calcium signaling during apoptotic removal is unclear. Using studies lines and the context of whole organism, we demonstrate that recognition induces both an acute sustained flux within phagocytes such essential engulfment. Furthermore, provide evidence release from endoplasmic reticulum entry extracellular via CRAC channels into are important Moreover, knockdown C. elegans stim-1 jph-1, two genes linked to...