A5039095165- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- Sepsis Diagnosis and Treatment
- Genomics and Phylogenetic Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotics Pharmacokinetics and Efficacy
- Mycobacterium research and diagnosis
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Gut microbiota and health
- Coronary Interventions and Diagnostics
- Vibrio bacteria research studies
- Pneumonia and Respiratory Infections
- Escherichia coli research studies
- Bacterial biofilms and quorum sensing
- ECG Monitoring and Analysis
- Actinomycetales infections and treatment
- Neonatal and Maternal Infections
Medical University of Graz
2013-2024
Institute of Medical Microbiology and Hygiene
2011-2022
Medical University of Vienna
2021
Austrian Agency for Health and Food Safety
2009-2021
Paracelsus Medical University
2021
University of Vienna
2021
Children's Health Ireland at Crumlin
2021
University of Graz
2002-2016
Freie Universität Berlin
1977-2015
Auguste-Viktoria-Klinik
2015
Short-term i.v. infusion of streptokinase was performed in 93 patients within 6 hours after the onset acute myocardial infarction. Twenty-six underwent angiography phase (group A) and 52 fourth week only B); 15 had no angiography. Seven died during hospital stay six suffered nonfatal reinfarctions. There were bleeding complications. In 11 21 group A patients, occluded coronary arteries opened 1 hour started. 84% groups B, infarct-related artery patent week. 75% arteries, residual luminal...
We investigated sinks as possible sources of a prolonged Klebsiella pneumonia carbapenemase (KPC)-producing oxytoca outbreak. Seven carbapenem-resistant K. isolates were identified in sink drains 4 patient rooms and the medication room. Investigations for resistance genes genetic relatedness environmental revealed that all harbored blaKPC-2 blaTEM-1 genetically indistinguishable. describe here clonal outbreak caused by KPC-2-producing oxytoca, handwashing reservoir.
Next-generation whole-genome sequencing is essential for high-resolution surveillance of bacterial pathogens, example, during outbreak investigations or source tracking and escape variant analysis. However, current global bioinformatic bottlenecks a long time to result with standard technologies demand new approaches.
Klebsiella oxytoca acts as a pathobiont in the dysbiotic human intestinal microbiota, causing antibiotic-associated hemorrhagic colitis (AAHC), but it also infects other organs, resulting pneumonia and urinary tract skin infections. The virulence of K. is still poorly understood. production specific cytotoxin has been linked to AAHC pathogenesis. To investigate clonal relationships with regard clinical origin attributes, we established multilocus sequence typing (MLST) method analyzed 74...
ABSTRACT A molecular assay for the simultaneous detection of a Staphylococcus aureus -specific gene and mecA gene, responsible resistance to methicillin in staphylococci, was evaluated. The included an automated DNA extraction protocol conducted with MagNA Pure instrument real-time PCR LightCycler instrument. performance robustness were evaluated suspension methicillin-resistant S. (MRSA) strain turbidity equivalent McFarland standard 0.5, which found be ideal working concentration....
For some time now, antibiotic-resistant bacterial strains have been found in the human population, foods, livestock and wild animals, as well surface waters. The entry of antibiotics resistant into environment plays an important role spread antibiotic resistance. goal present study was to monitor resistances through contamination wastewater. To assess extent transmission from sources environment, resistance patterns Escherichia coli isolated patients compared those sewage sludge. Our results...
ABSTRACT Antibiotic-associated hemorrhagic colitis (AAHC) is associated with Klebsiella oxytoca . This study analyzed whether cytotoxic properties are linked to specific subtypes of K. oxytoca. isolates from stools AAHC patients, healthy carriers, and diarrhea patients as well infections other organs were investigated. Cytotoxic effects on human epithelial cells limited the species not detectable for any species. Isolates showed highest proportion strains. Urinary or respiratory tract...
The soluble urokinase plasminogen activator receptor (suPAR) reflects inflammation. However, the prognostic value of suPAR measurements, particularly at very early onset systemic inflammatory response syndrome (SIRS), is less well defined.The potential levels in patients with SIRS was evaluated. From November 2010 until April 2013, 902 adult presenting were investigated. Blood samples for laboratory testing inflammation markers collected simultaneously initial blood cultures. performed using...
Abstract Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) are associated with various infectious pathogens. We analyzed the presence Chlamydia psittaci, pneumoniae, and trachomatis DNA in 47 nongastrointestinal 14 gastrointestinal MALT lymphomas, 37 nonmalignant control samples, 27 autoimmune precursor lesions by polymerase chain reaction amplification direct sequencing. In 13 (28%) were positive for C psittaci compared 4 (11%) samples (P = .09). was detected at...
To date, no outbreak of carbapenemase-producing bacteria has been reported for Austria. While outbreaks Klebsiella pneumoniae carbapenemase (KPC)-producing K. have increasingly reported, caused by KPC-producing oxytoca described yet, to the best our knowledge. We report an oxytoca. In 5 months, 31 strains were isolated from five patients. All patients admitted same medical intensive care unit in
The objective of this study was to compare epidemiology, causative pathogens, outcome, and levels laboratory markers inflammation community-onset (i.e. community-acquired healthcare-associated) hospital-acquired bloodstream infection (BSI) in South-East Austria.In prospective cohort study, 672 patients fulfilling criteria systemic inflammatory response syndrome with positive peripheral blood cultures (277 [192 community-acquired, 85 healthcare-associated BSI], 395 hospital-acquired) were...
Background Procalcitonin (PCT) has previously been proposed as useful marker to rule out bloodstream-infection (BSI). The objective of this study was evaluate the sensitivity different PCT cut-offs for prediction BSI in patients with community (CA)- and hospital-acquired (HA)-BSI. Methods A total 898 fulfilling systemic-inflammatory-response-syndrome (SIRS) criteria were enrolled prospective cohort at Medical University Graz, Austria. Of those 666 had positive blood cultures (282 CA-BSI, 384...
Abstract Klebsiella spp. that secrete the DNA-alkylating enterotoxin tilimycin colonize human intestinal tract. Numbers of toxigenic bacteria increase during antibiotic use, and resulting accumulation in lumen damages epithelium via genetic instability apoptosis. Here we examine impact this genotoxin on gut ecosystem. 16S rRNA sequencing faecal samples from mice colonized with oxytoca strains mechanistic analyses show is a pro-mutagenic affecting multiple phyla. Transient synthesis murine...
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has revolutionized diagnostics in culture-based microbiology. Commonly used MALDI-TOF MS systems clinical microbiology laboratories are MALDI Biotyper (Bruker Daltonics) and Vitek (bioMérieux), but recently the new EXS2600 (Zybio) been launched. This study aimed to evaluate performance of three devices by comparing results 16S rRNA gene sequencing. A set 356 previously collected difficult-to-identify...
The environmental bacterium
Percutaneous transluminal coronary angioplasty (PTCA) is widely used, but no quality control has been systematically performed as yet. A registry of all PTCA procedures established since October 1992 for the majority German community hospitals performing PTCA, representing about one third activity in Germany. Baseline demographic data, indication primary success and in-hospital clinical events were recorded. Each centre was visited at regular intervals to assure completeness reliability...
The effects of the commonly employed systemic vasodilators phentolamine, nitroprusside, and intravenous glyceryl trinitrate on cardiac performance, peripheral resistance, vascular capacitance, as judged by changes in left ventricular filling pressure, were compared 29 patients studied within 24 hours after onset acute myocardial infarction.To provide a common basis for comparison mean arterial pressure was lowered to same level about 80 mmHg previously normotensive 90 100 with history...