A5011986274- Reproductive Physiology in Livestock
- Genetic and phenotypic traits in livestock
- Effects of Environmental Stressors on Livestock
- Animal health and immunology
- Ruminant Nutrition and Digestive Physiology
- Antibiotic Resistance in Bacteria
- Reproductive System and Pregnancy
- Antimicrobial Resistance in Staphylococcus
- Animal Behavior and Welfare Studies
- Bacterial biofilms and quorum sensing
- Clostridium difficile and Clostridium perfringens research
- Vibrio bacteria research studies
- Pregnancy and preeclampsia studies
- Gut microbiota and health
- Reproductive Biology and Fertility
- Bacterial Identification and Susceptibility Testing
- Congenital Anomalies and Fetal Surgery
- Orthopedic Infections and Treatments
- Escherichia coli research studies
- Animal Disease Management and Epidemiology
- Veterinary Equine Medical Research
- Dermatological diseases and infestations
- Parasitic Infections and Diagnostics
- Liver Disease Diagnosis and Treatment
- Milk Quality and Mastitis in Dairy Cows
University of Veterinary Medicine Hannover, Foundation
2010-2024
Lower Saxony State Office for Consumer Protection and Food Safety
2017-2023
Spital Thurgau (Switzerland)
2021
Kantonsspital Münsterlingen
2018
Medical University of Graz
2014-2017
University of Graz
2003-2015
Kantonsspital Frauenfeld
2013
Ludwig-Maximilians-Universität München
2012
University of Veterinary Medicine
2009-2010
University of Veterinary Medicine Vienna
2007-2010
We investigated sinks as possible sources of a prolonged Klebsiella pneumonia carbapenemase (KPC)-producing oxytoca outbreak. Seven carbapenem-resistant K. isolates were identified in sink drains 4 patient rooms and the medication room. Investigations for resistance genes genetic relatedness environmental revealed that all harbored blaKPC-2 blaTEM-1 genetically indistinguishable. describe here clonal outbreak caused by KPC-2-producing oxytoca, handwashing reservoir.
Significance The human gut microbiota is a complex community of microbes with enormous metabolic potential. Recognition the significance bacterial metabolites in mediating host interactions and impact perturbations this ecosystem on health has increased dramatically. Antibiotic therapy eliminates not only pathogens but also some commensal enteric microbiota, sometimes leading to inflammation diarrhea. Understanding how microbial imbalance actually causes disease challenging. This study...
Klebsiella oxytoca acts as a pathobiont in the dysbiotic human intestinal microbiota, causing antibiotic-associated hemorrhagic colitis (AAHC), but it also infects other organs, resulting pneumonia and urinary tract skin infections. The virulence of K. is still poorly understood. production specific cytotoxin has been linked to AAHC pathogenesis. To investigate clonal relationships with regard clinical origin attributes, we established multilocus sequence typing (MLST) method analyzed 74...
The objective was to characterize the effects of Escherichia coli lipopolysaccharide (LPS) endotoxin (given i.v.) on luteal structure and function. Seven nonlactating German Holstein cows, 5.1 ± 0.8 years old (mean s.e.m.), were given 10 ml saline day (ovulation=day 1) a control estrous cycle. On subsequent cycle, they 0.5 μg/kg LPS. Luteal size decreased (from 5.2 3.8 cm², P≤0.05) within 24 h after LPS treatment remained smaller throughout remainder blood flow by 34% (P≤0.05) 3 lower for 72...
Fatty liver (steatosis) occurs in obese patients, among others, and is related to the development of diabetes type-2. Timely diagnosis steatosis therefore great importance. Steatosis also most common disease high-yielding dairy cattle during early lactation. This makes it a suitable animal model for studying steatosis. Furthermore, reference derived ultrasound parameters against "gold standard" possible by taking biopsy assessment fat concentration. The authors undertook this pilot study...
The introduction of transrectal colour Doppler sonography (CDS) has allowed the evaluation luteal blood flow (LBF) in cows. Because appropriate angiogenesis plays a decisive role functioning corpus luteum (CL), studies on LBF may provide valuable information about physiology and pathophysiology CL. Studies cyclic cows have shown that progesterone concentrations plasma can be more reliably predicted by than size (LS), especially during regression phase In contrast with non-pregnant cows,...
Binucleate trophoblast giant cells (BNC) in the bovine placenta produce glycoproteins, which are delivered into mother after fusion of BNC with uterine epithelial cells. During most time pregnancy, pregnancy-associated glycoproteins (PAGs) and prolactin-related protein-I (PRP-I) asparagine-linked lactosamine-type glycans terminating N -acetyl-galactosamine. We show by lectin histochemistry that terminal -acetyl-galactosamine (detected Dolichos biflorus agglutinin, DBA) placentomal is greatly...
The objective of this study was to examine the effects metritis and subclinical hypocalcemia on reduction uterine size in dairy cows using ultrasonography sonomicrometry. Four piezoelectric crystals were implanted via laparotomy into myometrium pregnant horn 12 pluriparous Holstein Friesian 3 weeks before calculated calving date. Sonometric measurements conducted daily from 2 days parturition (= Day 0) until 14 after then every other day 28. Distances between adjacent expressed relation...
Disturbed uterine involution impairs ovarian function in the first weeks after calving. This study analyzed long-term effect of metritis on luteal 47 lactating Holstein-Friesian cows during four postpartum estrous cycles. Cows with abnormal enlargement and malodorous lochia were classified as having (group M, n = 18), all others considered healthy H, 29). Luteal size was measured once between days 9 13 11; group 12), second 23; 18) fourth 7) phases. Serum progesterone concentration at same...
The present study determined vascular changes in the bovine corpus luteum (CL) at Day 16 (early maternal recognition period) and 40 early pregnancy compared them to CL from 12 of estrous cycle. CLs were analyzed central peripheral regions, where site-depending features vessels angiogenic factors are evident. same protein level endothelial cell marker von Willebrand factor was retained cycle pregnancy. pericytes smooth muscle cells using α-actin; decreased both regions CL. No significant...
When given intravenously (iv), lipopolysaccharide (LPS) transiently suppresses the structure and function of bovine corpus luteum (CL). This is associated with increased release prostaglandin (PG) F 2α metabolite. The underlying regulatory mechanisms this process remain, however, obscure. Therefore, aims study were: i) to investigate expression LPS receptor toll-like 4 ( TLR4 ) 2 TLR2 in CL during early, mid- late luteal phases; ii) further dissect LPS-mediated suppression function. As...
ABSTRACT Small-colony variants (SCVs) of bacteria are associated with recurrent and persistent infections. We describe for the first time SCVs Streptococcus tigurinus in a patient prosthetic joint infection. S. is novel pathogen mitis group causes invasive sought to characterize using experimental methods find possible genetic explanations their phenotypes. The were compared wild-type (WT) isolate phenotypic methods, including growth under different conditions, autolysis, visualization cell...
Persistence of the corpus luteum (CL) in cattle usually occurs during puerperium and is associated with interference prostaglandin (PG) F(2α) release from uterus. The objective present study was to determine for first time gene expressions persistent CL compared pregnancy cyclic CL. Three types biopsy samples were collected 32 lactating Holstein cows: (1) persisting 29 33 days after ovulation postpartum (persistent CL, n=9), (2) between early (CL pregnancy, n=8) (3) 10 13 estrous cycle...