A5004273391- Dialysis and Renal Disease Management
- Adolescent and Pediatric Healthcare
- Renal and Vascular Pathologies
- Global Health Care Issues
- Pediatric Urology and Nephrology Studies
- Healthcare Policy and Management
- Chronic Kidney Disease and Diabetes
- Corruption and Economic Development
- Chronic Disease Management Strategies
- Renal Transplantation Outcomes and Treatments
- Childhood Cancer Survivors' Quality of Life
- Physical Activity and Health
- Canadian Identity and History
- Organ Donation and Transplantation
- Mobile Health and mHealth Applications
- Health Systems, Economic Evaluations, Quality of Life
- Legal and Constitutional Studies
- Healthcare cost, quality, practices
- Platelet Disorders and Treatments
- American Constitutional Law and Politics
- Organ Transplantation Techniques and Outcomes
- Neonatal Health and Biochemistry
- Culture, Economy, and Development Studies
- Female Genital Mutilation/Cutting Issues
- Political Economy and Marxism
Royal Devon & Exeter NHS Foundation Trust
2010-2025
University of Bristol
2016-2025
University of Exeter
2010-2024
Royal Devon and Exeter Hospital
2010-2024
St Andrew's Healthcare
2023
Nokia (United Kingdom)
2023
Foreign, Commonwealth & Development Office
2022
Foreign and Commonwealth Office
2022
Children's Hospital at Westmead
2020
Temple University
2019
Accelerometers can identify certain physical activity behaviours, but not the context in which they take place. This study investigates feasibility of wearable cameras to objectively categorise behaviour type and participants’ accelerometer-identified episodes activity. Adults were given an Actical hip-mounted accelerometer a SenseCam camera (worn via lanyard). The onboard clocks on both devices time-synchronised. Participants engaged free-living activities for 3 days. data cleaned...
BackgroundRemote digital health interventions to enhance physical activity provide a potential solution improve the sedentary behaviour, inactivity, and poor health-related quality of life that are typical chronic conditions, particularly for people with kidney disease. However, there is need high-quality evidence support implementation in clinical practice. The Kidney BEAM trial evaluated effect 12-week intervention on life.MethodsIn single-blind, randomised controlled conducted at 11...
<h3>Background</h3> Mutation specific effects in monogenic disorders are rare. We describe atypical Fanconi syndrome caused by a heterozygous mutation HNF4A. Heterozygous HNF4A mutations cause beta cell phenotype of neonatal hyperinsulinism with macrosomia and young onset diabetes. Autosomal dominant idiopathic (a renal proximal tubulopathy) is described but no genetic has been defined. <h3>Methods Results</h3> report six patients for the p.R76W who have nephrocalcinosis addition to...
This trial assessed the feasibility and acceptability of Kidney BEAM, a physical activity emotional well-being self-management digital health intervention (DHI) for people with chronic kidney disease (CKD), which offers live on-demand sessions, educational blogs videos, peer support. In this mixed-methods, multicentre randomised waitlist-controlled internal pilot, adults established CKD were recruited from five NHS hospitals 1:1 to BEAM or waitlist control. Feasibility outcomes based upon...
Visual Abstract Export Background and objectives Young adults receiving kidney replacement therapy (KRT) have impaired quality of life may exhibit low medication adherence. We tested the hypothesis that wellbeing adherence are associated with psychosocial factors. Design, setting, participants, & measurements conducted a cross-sectional online survey for young on KRT. Additional clinical information was obtained from UK Renal Registry. compared outcomes by treatment modality using age-...
Abstract Background Physical activity and emotional self-management has the potential to enhance health-related quality of life (HRQoL), but few people with chronic kidney disease (CKD) have access resources support. The Kidney BEAM trial aims evaluate whether an evidence-based physical wellbeing programme (Kidney BEAM) leads improvements in HRQoL CKD. Methods This was a prospective, multicentre, randomised waitlist-controlled trial, health economic analysis nested qualitative studies. In...
Depression is common in people with chronic kidney disease, yet little known about how depression identified and managed as part of routine care.
In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact a PKD-specific activity programme on HRQoL and health. This substudy Kidney BEAM Trial evaluated 12-week educational digital health intervention for PKD. study was mixed-methods, single-blind, randomized waitlist-controlled trial. Sixty adults diagnosis PKD were 1:1 or waitlist control group. Primary outcome...
Summary Less than 50 patients are reported with platelet type von Willebrand disease (PT-VWD) worldwide. Several reports have discussed the diagnostic challenge of this versus closely similar disorder 2B VWD. However, no systematic study has evaluated dilemma globally. Over three years, a total 110 samples/data from eight countries were analysed. A molecular approach was utilised, analysing exon 28 factor (VWF) gene, and in mutation negative cases GP1BA gene. Our results show that 48...
Rationale & ObjectivePatients in late adolescence and early adulthood receiving renal replacement therapy (RRT) face disruption to normal activities, which affects well-being. We aimed define psychosocial lifestyle outcomes for young adults on RRT compared the general population.Study DesignWe undertook a cross-sectional survey (the SPEAK [Surveying Patients Experiencing Young Adult Kidney Failure] Study) using validated measures population comparator data from Health Survey England Avon...
Informal caregivers (i.e. family and friends) provide essential support to people with chronic kidney disease (CKD). Many informal experience mental health problems such as anxiety depression due the caregiving role, commonly have unmet psychological needs. One potential solution is cognitive behavioural therapy (CBT) self-help interventions that are less reliant on extensive involvement of healthcare professionals, which may increase access. Within intervention development phase MRC...
BackgroundThere is inequity in provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness a activity digital health intervention CKD.MethodsIn single-blind, 11 centre, randomised controlled trial, 340 adult participants CKD were randomly assigned to either or waitlist control. This study assesses difference Disease Quality Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3...
Key Points IgAN and MCD are the most common de novo glomerular diseases reported after COVID-19 vaccination, particularly mRNA vaccination. Membranous nephropathy, pauci-immune GN, collapsing GN have also been attributed to some with dual histologies. Recovery of kidney function proteinuria remission is more likely in by 4–6 months compared other diseases. Background Patients disease (GD) various renal histologies vaccination against SARS-CoV-2. Causality has not established, long-term...