A5035720463- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Bladder and Urothelial Cancer Treatments
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Heme Oxygenase-1 and Carbon Monoxide
- Platelet Disorders and Treatments
- DNA Repair Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Neuroendocrine Tumor Research Advances
- Urinary and Genital Oncology Studies
- Cancer-related gene regulation
- Autoimmune Bullous Skin Diseases
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- IgG4-Related and Inflammatory Diseases
- Ear and Head Tumors
- Genetic factors in colorectal cancer
- Metabolism and Genetic Disorders
- Lipoproteins and Cardiovascular Health
- Hepatitis B Virus Studies
- BRCA gene mutations in cancer
National and Kapodistrian University of Athens
2014-2023
Athens Medical Center
2021
University of Amsterdam
2020
Research Institute Hospital 12 de Octubre
2019
Laiko General Hospital of Athens
2010-2019
Division of Chemistry
2018
Alexandra Hospital
2012
Athens State University
2005-2007
University of Pittsburgh
1999
Washington University in St. Louis
1999
Objectives The release of neutrophil extracellular traps (NETs) represents a novel effector function in systemic lupus erythematosus (SLE) pathogenesis. However, the molecular mechanism underlying NET and how NETs mediate end-organ injury SLE remain elusive. Methods formation NET-related proteins were assessed peripheral blood biopsies from discoid proliferative nephritis, using immunofluorescence, immunoblotting, quantitative PCR ELISA. Autophagy was by immunofluorescence immunoblotting....
IL-33, a nuclear alarmin released during cell death, exerts context-specific effects on adaptive and innate immune cells, eliciting potent inflammatory responses. We screened blood, skin, kidney tissues from patients with systemic lupus erythematosus (SLE), autoimmune disease driven by unabated type I IFN production, found increased amounts of extracellular IL-33 complexed neutrophil traps (NETs), correlating severe, active disease. Using combination molecular, imaging, proteomic approaches,...
A staging system for patients with renal AL amyloidosis, based on eGFR (<50 ml/min/1.73 m2 ) and proteinuria (≥5 g/day) at diagnosis, as well criteria progression (≥25% reduction) response (≥30% reduction of without progression) were recently proposed. We validated these in a cohort 125 mostly treated bortezomib or lenalidomide. confirmed the prognostic value but also identified limitations which are only reduction. ratio 24h to sensitive marker risk accounts changes both eGFR:...
Abstract Background The VALidation of IGA (VALIGA) study investigated the utility Oxford Classification immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. Biopsies were scored by local pathologists followed central review Oxford. We had two distinct objectives: to assess how closely pathology findings associated with decision give corticosteroid/immunosuppressive (CS/IS) treatments, and determine impact differences MEST-C scoring between on clinical...
Minichromosome maintenance proteins (MCM) have recently emerged as novel proliferation markers with prognostic implications in several tumour types. This is the first study investigating MCM-2 and MCM-5 immunohistochemical expression a series of ovarian adenocarcinomas low malignant potential (LMP) tumours aiming to determine possible associations clinicopathological parameters, conventional index Ki-67, cell cycle regulators (p53, p27(Kip1), p21(WAF1) pRb) patients' outcome....
With wide use of fine-needle aspirates (FNA) for investigation thyroid nodules, a growing number parathyroid glands are being inadvertently aspirated cytologic study. Aiming to determine the effectiveness FNA differentiate between and lesions, all cases initially as nodules that had final histologic diagnosis lesion were retrieved from authors' files systematically reviewed delineate possible specific diagnostic criteria.From total 90,000 diagnoses 4740 isolated which was available. Among...
Abstract Bortezomib, in combination with dexamethasone (VD) or the addition of cyclophosphamide (VCD), is highly effective patients amyloid light-chain (AL) amyloidosis. Currently, VCD considered as a primary regimen for AL, but it not clear whether to VD further and significantly improves efficacy, given substantial activity bortezomib itself. We retrospectively compared outcomes 101 AL amyloidosis who received ( n =59) =42) two consecutive periods. Early mortality after adjustment Mayo...
Key Points IgAN and MCD are the most common de novo glomerular diseases reported after COVID-19 vaccination, particularly mRNA vaccination. Membranous nephropathy, pauci-immune GN, collapsing GN have also been attributed to some with dual histologies. Recovery of kidney function proteinuria remission is more likely in by 4–6 months compared other diseases. Background Patients disease (GD) various renal histologies vaccination against SARS-CoV-2. Causality has not established, long-term...
To elucidate the role of replication protein A (RPA) in both superficial (Ta-T1) and muscle-invasive (T2-T4) urothelial carcinomas (UCs), investigating its potential prognostic usefulness.Paraffin-embedded tissue from 156 patients with bladder UC was immunostained for RPA1 RPA2.RPA1 RPA2 labelling indexes (LIs) decreased increasing histological grade (both P < 0.001) T-category entire cohort (P = 0.008 0.001, respectively) 0.014 0.012, respectively). expression positively correlated...
Monoclonal immunoglobulin deposition disease (MIDD) is characterized by non-organized immunoglobulin-fragments along renal basement membranes with subsequent organ deterioration. Treatment directed against the immunoglobulin-producing clone. We treated 18 MIDD patients bortezomib-based regimens (12 received bortezomib-dexamethasone, 6 bortezomib-dexamethasone cyclophosphamide). Eleven (61%) achieved a hematologic response, but only (33.3%) reached to complete (CR) or very good partial...
Immunoglobulin A nephropathy (IgAN) is among the commonest glomerulonephritides in Greece and an important cause of end-stage kidney disease (ESKD) with insidious chronic course. Thus, recently published International IgAN prediction tool could potentially provide valuable risk stratification guide appropriate treatment module. This study aimed to externally validate this using a patient cohort from registry Greek Society Nephrology.We validated predictive performance two full models (with...
Abstract Background Chemokine receptor signaling pathways are implicated in the pathobiology of renal cell carcinoma (RCC). However, clinical relevance CXCR2 receptor, mediating effects all angiogenic chemokines, remains unclear. SOCS (suppressor cytokine signaling)-3 is a negative regulator cytokine-driven responses, contributing to interferon-α resistance commonly used treat advanced RCC with limited information regarding its expression RCC. Methods In this study, and SOCS-3 were...