A5072997413- Cerebral Venous Sinus Thrombosis
- Pituitary Gland Disorders and Treatments
- Glaucoma and retinal disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Migraine and Headache Studies
- Traumatic Brain Injury Research
- Nasolacrimal Duct Obstruction Treatments
- Colorectal Cancer Screening and Detection
- Spine and Intervertebral Disc Pathology
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Trigeminal Neuralgia and Treatments
- Reconstructive Facial Surgery Techniques
- Spinal Hematomas and Complications
- Renal Diseases and Glomerulopathies
- Traumatic Ocular and Foreign Body Injuries
- Nasal Surgery and Airway Studies
- Renal cell carcinoma treatment
- Muscle and Compartmental Disorders
- Sleep and Wakefulness Research
- Metabolomics and Mass Spectrometry Studies
- Dialysis and Renal Disease Management
- Psychosomatic Disorders and Their Treatments
- Gastric Cancer Management and Outcomes
University of Birmingham
2019-2025
University Hospitals Birmingham NHS Foundation Trust
2020-2025
University of Michigan
2024-2025
Queen Elizabeth Hospital
2025
University of Bristol
2025
Queen Elizabeth Hospital Birmingham
2022-2024
Queen Elizabeth Hospital
2022
University of Calgary
2022
King's College Hospital NHS Foundation Trust
2016
Abstract Therapeutics to reduce intracranial pressure are an unmet need. Preclinical data have demonstrated a novel strategy lower using glucagon-like peptide-1 (GLP-1) receptor signalling. Here, we translate these findings into patients by conducting randomized, placebo-controlled, double-blind trial assess the effect of exenatide, GLP-1 agonist, on in idiopathic hypertension. Telemetric catheters enabled long-term monitoring. The enrolled adult women with active hypertension (intracranial...
Cognitive function can be affected in conditions with raised intracranial pressure (ICP) such as idiopathic hypertension (IIH). Drugs used off label to treat ICP also have cognitive side effects, underscoring the unmet need for effective therapeutics which reduce without worsening cognition. The Glucagon Like Peptide-1 (GLP-1) receptor agonist, exenatide, has been shown significantly IIH, therefore this study aimed determine effects of exenatide on cognition IIH.
Abstract Objective To gain initial insight into the efficacy to lower intracranial pressure (ICP), side effects, and effects on cognition of five drugs commonly used treat idiopathic hypertension (IIH). Background Limited clinical data exist for treatment IIH. Impaired is recognized in IIH can be exacerbated by medications. Methods This human experimental medicine study was a secondary analysis that focused an unblinded randomized, sequential, cross‐over extension previously completed...
There is an unmet need for noninvasive biomarkers of intracranial pressure (ICP), which manifests as papilledema that can be quantified by optical coherence tomography (OCT) imaging.To determine whether OCT the optic nerve head in could act a surrogate measure ICP.This longitudinal cohort study used data collected from 3 randomized clinical trials were conducted between April 1, 2014, and August 2019. Participants who female had active idiopathic hypertension enrolled 5 National Health...
Regulation of food intake and energy balance is critical to survival. Hunger develops as a response deficit drives food-seeking consumption. However, motivations eat are varied in nature, promoted by factors other than deficit. When dysregulated, non-homeostatic consume can contribute disorders intake, adding the increasing prevalence restrictive eating obesity. Melanin-concentrating hormone (MCH) neurons have been implicated regulation feeding behavior, addition number fundamental behaviors...
Abstract Objectives Intracranial pressure (ICP) has been thought to vary diurnally. This study evaluates diurnal ICP measurements and quantifies changes in occurring with body posture active idiopathic intracranial hypertension (IIH). Methods prospective observational utilized telemetric monitoring people IIH. Participants had the Raumedic p-Tel intraparenchymal device (Raumedic, Hembrechts, Germany) surgically inserted. Changes supine position were evaluated. Then, was measured standing,...
Background: Idiopathic intracranial hypertension (IIH) is characterized by increased pressure occurring predominantly in women with obesity. The pathogenesis not understood. We have applied untargeted metabolomic analysis using ultrahigh-performance liquid chromatography–mass spectrometry to characterize the cerebrospinal fluid (CSF) and serum IIH compared control subjects. Methods findings: Samples were collected from patients (n = 66) active disease at baseline again 12 months following...
To conduct an audit of patients presenting with long-term urinary catheter (LTC)-associated problems to our Emergency Department (ED) and assess the availability community nursing support for their LTC. We also estimated cost implication health service potential solutions this issue, as although care is provided by nurses, LTC are common presentations ED often significant burdens services.A study was carried out all a problem, specifically studying LTCs reason presentation, district nurses'...
Abstract Background Multiple lumbar punctures have historically been a strategy to relieve headaches associated with idiopathic intracranial hypertension despite limited clinical evidence of long-term efficacy. Lumbar puncture is typically straightforward procedure minimal complications reported, however, serious can occur. Lumbar-puncture-related spinal hematomas are rare but lead irreversible paralysis. Case presentation We report case 28-year-old Caucasian woman who was treated multiple...
Idiopathic intracranial hypertension (IIH) is a disease characterised by elevated pressure (ICP). The impact of straining and exercise on ICP regulation poorly understood yet clinically relevant to IIH patient care. We sought investigate the Valsalva manoeuvres (VMs) cerebrovascular haemodynamics in IIH. People with were prospectively enrolled had an intraparenchymal telemetric sensor inserted. Three participants (age [mean ± standard deviation]: 40.3 13.9 years) underwent continuous...
Abstract Therapeutics to reduce intracranial pressure are an unmet need. Pre-clinical data has demonstrated a novel strategy lower using glucagon-like peptide-1 receptor signaling. Here, we translate these findings into patients by conducting randomized, placebo controlled, double-blind trial assess the effect of exenatide, agonist, on in idiopathic hypertension. Telemetric catheters enabled long-term monitoring. The enrolled adult women with active hypertension (intracranial >25 cmCSF...
Introduction Raised intracranial pressure (ICP) causes significant morbidity and mortality in a range of conditions including idiopathic hypertension (IIH) traumatic brain injury (TBI). Exenatide is GLP-1 receptor agonist; pre-clinical data demonstrates its ability to reduce ICP. GLP-1R agonists have also been shown neuro-protective properties models TBI. The objectives this study are assess the biological effect Glucagon-like Peptide 1 (GLP-1) agonist on ICP cohort participants with IIH,...
Introduction: The first line treatment for nasolacrimal duct obstruction (NLDO) is external dacrocystorhinostomy (DCR). Following DCR, patients are required to return Tilganga Institute of Ophthalmology (TIO) six weeks postoperatively the removal a silicone stent. As majority travel large distances at significant cost reach TIO, most often remain within Kathmandu during this interval. This places financial burden on patients.
 Methods: A randomized controlled trial was designed compare...
Background Pre-clinical data demonstrates the ability of Exenatide, a GLP-1R agonist, to reduce CSF secretion and ICP.1 Existing agonists are widely used treat obesity diabetes (but do not cause hypoglycaemia). Methods Randomised, placebo controlled, double-blind trial Exenatide in women with active IIH. Participants were randomised 1:1 (10mcg twice daily sub-cutaneous) or for 12 weeks. Telemetric, intraparenchymal ICP monitors (Raumedic) recorded over Analysis was by hierarchical...
Regulation of food intake and energy balance is critical to survival. Hunger develops as a response deficit drives food-seeking consumption. However, motivations eat are varied in nature, promoted by factors other than deficit. When dysregulated, non-homeostatic consume can contribute disorders intake, adding the increasing prevalence restrictive eating obesity. Melanin-concentrating hormone (MCH) neurons have been implicated regulation feeding behavior, addition number fundamental behaviors...