A5082005077- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Proteoglycans and glycosaminoglycans research
- Corneal surgery and disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Alcoholism and Thiamine Deficiency
- Retinal Development and Disorders
- Agriculture Sustainability and Environmental Impact
- Diet and metabolism studies
- Cerebral Venous Sinus Thrombosis
- RNA Interference and Gene Delivery
- Vitamin C and Antioxidants Research
- Ophthalmology and Eye Disorders
- Ocular Diseases and Behçet’s Syndrome
- Traumatic Brain Injury Research
- Ocular Infections and Treatments
- Sirtuins and Resveratrol in Medicine
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Glycosylation and Glycoproteins Research
- CRISPR and Genetic Engineering
- Circular RNAs in diseases
- Intraocular Surgery and Lenses
University of Birmingham
2016-2025
University of Brawijaya
2023
The Edgbaston Hospital
2018-2019
NIHR Surgical Reconstruction and Microbiology Research Centre
2017
National Institute for Health Research
2017
Queen Elizabeth Hospital Birmingham
2017
Traumatic brain injury (TBI) is the leading cause of death and disability in people younger than 45 Western countries. Despite many studies, no reliable biomarkers have been found to assess TBI severity predict recovery. MicroRNA (miRNA) profiling has become widely used identify therapeutic targets. Through use TaqMan Array Human A+B Cards, expression 754 miRNAs was analyzed serum five mild (mTBI) patients with extra-cranial (EC), severe (sTBI) EC, healthy volunteers (HV) at 1 day 15 days...
PURPOSE.To evaluate the efficacy of anti-VEGF agents for treating choroidal neovascularization (CNV) when delivered topically using novel cell-penetrating peptides (CPPs) compared with delivery by intravitreal (ivit) injection.METHODS.CPP toxicity was investigated in cell cultures.Ivit concentrations ranibizumab and bevacizumab after topical administration were measured ELISA.The biological þ CPP complexes ivit injections an established model CNV.RESULTS.CPPs nontoxic vitro.In vivo, eye drop...
Mitochondrial dynamics are regulated by a complex system of proteins representing the mitochondrial quality control (MQC). MQC balances antagonistic forces fusion and fission determining cell fates. In several neurological disorders, dysfunctional mitochondria show significant changes in gene protein expression contribute to pathophysiological mechanisms damage. this study, we evaluated main involved rats receiving traumatic brain injury (TBI) different severities. At 6, 24, 48 120 hours...
Scarring/Opacity on the surface of eye and vascularisation following infectious diseases, inflammation corneal trauma are often a leading cause blindness. The 'gold standard' treatment to prevent scarring is application amniotic membrane (AM) ocular in acute stage injury. Although clinically effective, use AM associated with biological variability unpredictable responses. Potential health risks including disease transmission, significant ethical issues surrounding tissue donation process...
Abstract Disorganization of the transparent collagenous matrix in cornea, as a consequence variety infections and inflammatory conditions, leads to corneal opacity sight-loss. Such opacities are leading cause blindness, according WHO. Public health programs target prevention scarring, but only curative treatment established scarring is through transplantation. Although attempts minimize aggressive control infection inflammation made, there has been little progress development anti-scarring...
Purpose: Aging is a risk factor for dry eye disease. The aim of this study was to investigate if aging associated with range signs disease, including tear hyperosmolarity, reduced nerve density, and increased dendritic cell number, in mice. Method: Healthy C57BL/6 female mice, aged 2 months (young, n = 10) 22 (aged, 11) were used. Clinical assessments included corneal sensitivity (Cochet-Bonnet esthesiometry), secretion (Phenol red thread test), film osmolarity (TearLab osmometer), thickness...
Abstract Raised intracranial pressure (ICP) is associated with altered cerebral hemodynamics and cephalic pain. The relationship between the algetic response cortical neurovascular changes in raised ICP unclear. This study aimed to evaluate this determine if lowering (using a glucagon like peptide-1 receptor agonist) could ameliorate response. We also sought explore role of calcitonin gene-related peptide pain driven by inhibiting signalling quantifying In rat model ICP, created...
Abstract There is unmet clinical need for biomarkers to predict recovery or the development of long-term sequelae mild traumatic brain injury, a highly prevalent condition causing constellation disabling symptoms. A substantial proportion patients live with long-lasting affecting their quality life and ability work. At present, symptoms can be assessed through tests, however, there are no imaging laboratory tests fully reflective pathophysiology routinely used by clinicians characterise...
Compartmentalized redox faults are common to ageing diseases. Dietary constituents catabolized NAD(H) donating electrons producing proton-based bioenergy in coevolved, cross-species and cross-organ networks. Nicotinamide NAD deficiency from poor diet or high expenditure causes pellagra, an dementing disorder with lost robustness infection stress. stress induce Nicotinamide-N-methyltransferase (NNMT) improving choline retention but consume methyl groups. High NNMT activity is linked...
Purpose.: To investigate whether Decorin, a matrikine that regulates extracellular matrix (ECM) deposition, can reverse established trabecular meshwork (TM) fibrosis, lower IOP, and reduce progressive retinal ganglion cell (RGC) death in novel rodent model of TM fibrosis. Methods.: Adult rats had intracameral (IC) injections human recombinant (hr) TGF-β over 30 days (30d; to induce raise initiate RGC by 17d) or PBS (controls) visually evoked potentials (VEP) were measured at 30d evaluate...
Abstract Eye drops are the most common and inexpensive approach to topical ocular drug delivery. offer a noninvasive treatment strategy; however, this can be detrimental therapeutic efficacy when compared invasive methods such as surgeries, implants, injections. Improvements of delivery drugs tissues currently being explored much work centers on adjusting formulation eye prolonging bioavailability agent. This is often in preference improving other patient‐focused or clinical factors. In...
Abstract Traumatic brain injury (TBI) is set to become the leading cause of neurological disability across all age groups. Currently, no reliable biomarkers exist help diagnose severity TBI identify patients who are at risk developing secondary injuries. Thus, discovery for management would improve clinical interventions. Inflammatory markers particularly suited biomarker as leads very early alterations in inflammatory proteins. Using Proseek Multiplex Inflammation assay, we measured that...