A5044439658- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Catalysis and Oxidation Reactions
- Fetal and Pediatric Neurological Disorders
- Advanced Neural Network Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Catalytic Processes in Materials Science
- Education, Psychology, and Social Research
- Brain Tumor Detection and Classification
- Medical Imaging Techniques and Applications
- Traumatic Brain Injury Research
- Acute Lymphoblastic Leukemia research
- Ionic liquids properties and applications
- Medical Image Segmentation Techniques
- Nonlinear Dynamics and Pattern Formation
- Electrochemical Analysis and Applications
- Catalysis and Hydrodesulfurization Studies
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Polyoxometalates: Synthesis and Applications
- Oxidative Organic Chemistry Reactions
- Retinoids in leukemia and cellular processes
Aston University
2019-2025
Health & Life (Taiwan)
2023-2025
University Hospital Kralovske Vinohrady
2024
Charles University
2024
University of Birmingham
2012-2023
Birmingham Children's Hospital
2013-2023
Birmingham Women’s and Children’s NHS Foundation Trust
2019-2022
Kerima (Czechia)
2021
University Hospitals Birmingham NHS Foundation Trust
2018
Technical University of Liberec
2017
The aim of this study was to assess the efficacy three‐dimensional texture analysis (3D TA) conventional MR images for classification childhood brain tumours in a quantitative manner. dataset comprised pre‐contrast T 1 ‐ and 2 ‐weighted MRI series obtained from 48 children diagnosed with (medulloblastoma, pilocytic astrocytoma ependymoma). 3D 2D TA were carried out on using first‐, second‐ higher order statistical methods. Six supervised algorithms trained most influential textural features,...
To investigate the robustness of constrained and simultaneous intravoxel incoherent motion (IVIM) fitting methods estimated IVIM parameters (D, D* f) for applications in brain low-perfused tissues.Model data simulations relevant to tumor tissues were computed assess accuracy, relative bias, reproducibility (CV%) estimating parameters. The performed at a series signal-to-noise ratio (SNR) levels influence noise on fitting.The from model found significantly different (P < 0.05) using low SNR....
Brain tumours are the most common solid cancers in children UK and cause of cancer deaths this age group. Despite current advances MRI, non‐invasive diagnosis paediatric brain has yet to find its way into routine clinical practice. Radiomics , high‐throughput extraction analysis quantitative image features (e.g. texture), offers potential solutions for tumour characterization decision support. In search diagnostic oncological markers, primary aim work was study application MRI texture (TA)...
The imaging and subsequent accurate diagnosis of paediatric brain tumours presents a radiological challenge, with magnetic resonance playing key role in providing tumour specific information. Diffusion weighted perfusion are commonly used to aid the non-invasive children's tumours, but usually evaluated by expert qualitative review. Quantitative studies mainly single centre modality. aim this work was combine multi-centre diffusion imaging, machine learning, develop learning based...
Abstract To determine if apparent diffusion coefficients (ADC) can discriminate between posterior fossa brain tumours on a multicentre basis. A total of 124 paediatric patients with (including 55 Medulloblastomas, 36 Pilocytic Astrocytomas and 26 Ependymomas) were scanned using weighted imaging across 12 different hospitals 18 scanners. Apparent coefficient maps produced histogram data was extracted from tumour regions interest. Total histograms metrics (mean, variance, skew, kurtosis 10th,...
Introduction: T1w/T2w ratio mapping, combining voxel-wise signal intensities in T1-weighted (T1w) and T2-weighted (T2w) structural MRI, has been used to investigate cortical architecture the brain, but also shown promise tissue discrimination, even tumor tissue. Methods: The current study aimed whether inclusion of these established maps, or a similar T1w – T2w combined map, can improve performance on novel task; automated segmentation pediatric brain cases from BraTS-PED 2024 dataset....
Abstract Brain tumors represent the highest cause of mortality in pediatric oncological population. Diagnosis is commonly performed with magnetic resonance imaging. Survival biomarkers are challenging to identify due relatively low numbers individual tumor types. 69 children biopsy-confirmed brain were recruited into this study. All participants had perfusion and diffusion weighted imaging at diagnosis. Imaging data processed using conventional methods, a Bayesian survival analysis...
PURPOSE To determine the optimal daunorubicin dose and number of 7 + 3 induction cycles in newly diagnosed AML, this randomized controlled trial compared a once daily 60 mg/m 2 with 90 first one versus two induction. PATIENTS AND METHODS Patients age 18-65 years AML were randomly assigned to plus cytarabine. marrow blasts below 5% on day 15 after receive second cycle or no cycle. RESULTS Eight hundred sixty-four patients median 52 assigned. After preplanned interim analysis showing...
Background Pediatric retroperitoneal tumors in the renal bed are often large and heterogeneous, their diagnosis based on conventional imaging alone is not possible. More advanced methods, such as diffusion‐weighted (DW) MRI use of intravoxel incoherent motion (IVIM), have potential to provide additional biomarkers that could facilitate noninvasive diagnosis. Purpose To assess an IVIM model for childhood malignant abdominal discrimination benign from lesions. Study Type Retrospective....
Introduction:In vivo 31 P Magnetic Resonance Spectroscopy (MRS) measures phosphorus-containing metabolites that play an essential role in many disease processes.An advantage over 1 H MRS is total choline can be separated into phosphocholine and glycerophosphocholine which have opposite associations with tumour grade.We demonstrate provide robust metabolic information on acceptable timescale to yield of clinical importance.Methods: All MRI examinations were carried out a 3T whole body scanner...
This study aimed to investigate the reliability of intravoxel incoherent motion (IVIM) model derived parameters D and f their dependence on b value distributions with a rapid three acquisition protocol.Diffusion models for brain, kidney, liver were assessed bias, error, reproducibility estimated IVIM using values 0 1000, between 200 900, at signal-to-noise ratios (SNR) 40, 55, 80. Relative errors used estimate optimal each tissue scenario. Sixteen volunteers underwent brain DW-MRI, which...
Background and aims Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by disease-associated variants in the alpha-galactosidase A gene ( GLA ). FD known cause of stroke younger patients. There are limited data on prevalence risk unselected Methods prospective nationwide study including 35 (78%) all 45 centers consecutive patients admitted during three months. Clinical were collected RES-Q database. was diagnosed using dried blood spots stepwise manner: males—enzymatic...
The rheology, and underpinning colloidal interactions, of ionic liquid (IL) dispersions silica have been investigated using bulk rheological measurements with magnetic resonance (MR) velocity relaxation measurements. Two liquids were investigated: tetradecyl(trihexyl)phosphonium bistriflamide ([P6,6,6,14][NTf2]) 1-butyl-methylimidizolium tetrafluoroborate ([C4mim][BF4]), in the absence presence hydrophilic nanoparticles (Aerosil 200). Bulk rheology was probed shear stress viscosity as a...
To investigate correlations between MRI perfusion metrics measured by dynamic susceptibility contrast and arterial spin labelling in paediatric brain tumours.15 patients with tumours were scanned prospectively using pseudo-continuous (ASL) (DSC-) a pre-bolus to minimise agent leakage. Cerebral blood flow (CBF) maps produced ASL. volume (CBV) without leakage correction the Boxerman technique parameter, K2, from DSC data. Correlations investigated.Histology resulted following diagnoses:...
Structural segmentation of T1-weighted (T1w) MRI has shown morphometric differences, both compared to controls and longitudinally, following a traumatic brain injury (TBI). While many patients with TBI present abnormalities on structural images, most neuroimaging software packages have not been systematically evaluated for accuracy in the presence these pathology-related abnormalities. The current study aimed assess whether acute lesions (MRI acquired 7–71 days post-injury) cause error...
Advection-reaction-diffusion (ARD) waves in the Belousov-Zhabotinsky reaction steady Taylor-Couette vortices have been visualized using magnetic-resonance imaging and simulated an adapted Oregonator model. We show how propagating wave behavior depends on ratio of advective, chemical diffusive time scales. In simulations, inward spiral flamelets are observed at high Damköhler number (Da). At low Da, distributes itself over several then propagates inwards as contracting ring pulses--also...
The low frequency forcing of chemical oscillations by temperature is investigated experimentally in the Belousov-Zhabotinsky (BZ) reaction and simulations Oregonator model with Arrhenius dependence rate constants. Forcing leads to modulation frequency. number response cycles per cycle given ratio natural phase locking only observed when this a whole amplitude small. global flow-distributed tubular reactor also synchronisation variation band position external signal, reflecting periodic temperature.
A recent study indicated that the water-saturated ionic liquid (IL) trihexyl(tetradecyl)phosphonium chloride ([P6,6,6,14][Cl]) provided a viable electrolyte for Mg-air battery. However, there is limited literature on properties of IL-water mixtures as battery electrolytes. The physical [P6,6,6,14][Cl] were studied with addition both water and metal salts (MgCl2 LiCl) using conductivity self-diffusion coefficient measurements. samples at low concentrations surprisingly enhanced by salt,...
Abstract Background Relative cerebral blood volume (rCBV) measured using dynamic susceptibility-contrast MRI can differentiate between low- and high-grade pediatric brain tumors. Multicenter studies are required for translation into clinical practice. Objective We compared leakage-corrected perfusion parameters acquired at multiple centers in Materials methods Eighty-five patients underwent pre-treatment scans four centers. protocols were variable. analyzed data the Boxerman...