A5075823559- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Neurological Disorders and Treatments
- Peripheral Artery Disease Management
- Cerebral Venous Sinus Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
- Long-Term Effects of COVID-19
- Pharmacogenetics and Drug Metabolism
- COVID-19 and healthcare impacts
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Valve Diseases and Treatments
- Retinal and Optic Conditions
- Computational Drug Discovery Methods
- Hemodynamic Monitoring and Therapy
- Education, Psychology, and Social Research
- Coronary Interventions and Diagnostics
- Hormonal Regulation and Hypertension
- Climate Change and Health Impacts
- Retinal Imaging and Analysis
- Non-Invasive Vital Sign Monitoring
- Trauma and Emergency Care Studies
- Neurological Disease Mechanisms and Treatments
Krajská Zdravotní
2019-2025
Strix Chomutov (Czechia)
2025
Boston Medical Center
2021-2022
Boston University
2021-2022
Grady Memorial Hospital
2021
Universidade Federal do Rio Grande do Sul
2021
Thales (Portugal)
2020-2021
Hospital de Clínicas de Porto Alegre
2021
County Hospital
2017
Max Planck Institute for Human Cognitive and Brain Sciences
2013
<h3>Background and Objectives</h3> Declines in stroke admission, IV thrombolysis (IVT), mechanical thrombectomy volumes were reported during the first wave of COVID-19 pandemic. There is a paucity data on longer-term effect pandemic over course year through second We sought to measure admissions, intracranial hemorrhage (ICH), IVT, 1-year period at onset (March 1, 2020, February 28, 2021) compared with immediately preceding 2019, 29, 2020). <h3>Methods</h3> conducted longitudinal...
Background and aims: Central retinal artery occlusion (CRAO) is a rare but significantly underestimated form of ischemic stroke. There still no definite recommendation for treatment. One the considered currently increasingly preferred options intravenous thrombolysis. We present results multicenter retrospective study to assess safety effectiveness thrombolytic treatment in CRAO. Methods: All patients with CRAO from six centers who received thrombolysis were included study. The intervention...
Introduction: Treatment of acute stroke has its clear rules and established standards. However, in the case a very early recurrence, situation is unclear, there no recommendation options are limited. We present results multicenter retrospective study using prolonged low-dose intravenous thrombolysis. Methods: The ESR_PROLONG (2020-2024) included consecutive patients who were given thrombolysis (20 mg alteplase continuously for 10 hours) during an (within hours after standard recanalization...
<i>Background:</i> Public awareness campaigns are conducted to increase stroke awareness, yet evidence of their long-term effectiveness is limited. Since 2006, the Czech Stroke Society has an educational campaign throughout Republic (CR) about stroke. This report evaluates this by comparing results a nationwide survey on in 2009 with from 2005. <i>Methods:</i> In 2009, was CR using same methodology as 2005 and employing 3-stage random sampling method (area, household,...
Knowledge of the implementation gap would facilitate use intravenous thrombolysis in stroke, which is still low many countries. The study was conducted to identify national targets for utilisation and logistics thrombolysis.Multicomponent interventions by stakeholders health care optimise prehospital hospital management with goal fast accessible every candidate. Implementation results were documented from prospectively collected cases all 45 stroke centres nationally. thrombolytic rate...
This article describes policy processes that have led to the re-organisation of stroke care in Czech Republic since 2011, which has been part a broader process concentration several medical fields. Currently, is provided by 13 Comprehensive and 32 Primary Stroke Centres. The paper explains factors supported reform implementation, reviews implications, discusses future challenges. Mandatory reporting quality indicators, introduction benchmarking system, integration with pre-hospital emergency...
Background and aims Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by disease-associated variants in the alpha-galactosidase A gene ( GLA ). FD known cause of stroke younger patients. There are limited data on prevalence risk unselected Methods prospective nationwide study including 35 (78%) all 45 centers consecutive patients admitted during three months. Clinical were collected RES-Q database. was diagnosed using dried blood spots stepwise manner: males—enzymatic...
Warfarin is commonly used for the treatment and prevention of arterial venous thromboembolism but its use hindered by risk bleeding. The main reason this a narrow therapeutic index wide response variability after warfarin treatment. These shortcomings affect clinical outcomes including bleeding complications may be associated with variant polymorphisms in CYP2C9 VKORC1 genes.It was aim study to assess impact total allele count genes on related treatment.In retrospective cohort-design study,...
Background and Purpose— Diagnostic transcranial Doppler ultrasound (TCD) is commonly used in patients with acute stroke before or during treatment intravenous thrombolysis (IVT). We aimed to assess how much TCD delays IVT initiation whether influences outcomes. Methods— analyzed data from the SITS-ISTR (Safe Implementation of Thrombolysis Stroke–International Stroke Register) collected December 2002 2011. Outcomes were door-to-needle time, symptomatic intracerebral hemorrhage, functional...
The coexistence of underlying causes in patients with transient ischemic attack (TIA) or minor stroke as well their associated 5-year risks are not known.
Background The benefit of intravenous thrombolysis is time dependent. It remains unclear, however, whether dramatic shortening door-to-needle (DNT) among different types hospitals nationwide does not compromise safety and still improves outcome. Methods Results Multifaceted intervention to shorten DNT was introduced at a national level, prospectively collected data from registry between 2004 2019 were analyzed. Generalized estimating equation used identify the association outcomes...
Objective: The objective of this study was to evaluate the feasibility and effectiveness an innovative school stroke heart attack educational programme for children. Design: Non-randomised controlled trial with intervention control group conducted in set time periods. Results were compared among periods both groups also between groups. Setting: included children from 47 schools Czech Republic. Children 37 one county ( N = 2,436) participated as target population. involved 900 pupils 10...
Incidence a prevalence cévní mozkové příhody (CMP) v České republice je ve srovnání s ostatními vyspělými zeměmi Evropy stále vysoká. CMP patří k nejčastějším příčinám úmrtí hlavní příčinou trvalé invalidity u dospělých. To má značný dopad na ekonomiku zdravotnictví, případě i do sociální situace nemocného. Nové postupy trendy akutní péči, které jsou uplatňovány komplexních cerebrovaskulárních centrech iktových centrech, významně zvyšují šance pacientů úspěšné vyléčení. Těžiště péče však...
Data from clinical practice show that median door-to-needle time (DNT) for intravenous thrombolysis (IVT) remains around 60 minutes. However, many reports documented hospital logistics could be substantially streamlined and DNT shortened below 30 Given Czech stroke care reform, centers have recently been changing their logistical pathways with the aim to initiate IVT quicker than before.3 Several introduced one-stop management, which means all suspected acute ischemic (AIS) patients are...
Despite a significant transformation of ischaemic stroke management, it remains one the leading causes death, disability, functional impairment and cognitive deficits. With advent intravenous thrombolysis mechanical thrombectomy, is not an untreatable disease, mostly occurring in older people, any more. The most common cause cardioembolic strokes atrial fibrillation or flutter prevalent arrhythmia. aim this short communication to describe methodology Czech guidelines development....