Antonı́n Krajina
A5033353214- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease and Transplantation
- Peripheral Artery Disease Management
- Stroke Rehabilitation and Recovery
- Liver Disease Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Renal and Vascular Pathologies
- Aortic aneurysm repair treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Abdominal vascular conditions and treatments
- Organ Transplantation Techniques and Outcomes
- Vascular Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Central Venous Catheters and Hemodialysis
- Vascular anomalies and interventions
- Abdominal Trauma and Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Hormonal Regulation and Hypertension
- Cerebral Venous Sinus Thrombosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Adrenal Hormones and Disorders
Charles University
2016-2025
University Hospital Hradec Králové
2016-2025
University of Hradec Králové
2017-2024
Hospital de Egas Moniz
2022
University of Thessaly
2022
Boston University
2022
Boston Medical Center
2022
University Hospital Ostrava
2012-2022
Ocní klinika
1993-2018
University of Chemistry and Technology, Prague
2017
Despite the well-established potent benefit of mechanical thrombectomy (MT) for large vessel occlusion (LVO) stroke, access to MT has not been studied globally. We conducted a worldwide survey countries on 6 continents define (MTA), disparities in MTA, and its determinants global scale.Our was 75 through Mission Thrombectomy 2020+ network between November 22, 2020, February 28, 2021. The primary end points were current annual operator availability, center availability. MTA defined as...
Advanced imaging has been increasingly used for patient selection in endovascular stroke therapy. The impact of modality on therapy clinical outcomes extended time window remains to be defined. We aimed study this relationship and compare it that noted early-treated patients. Patients from a prospective multicentric registry (n=2008) with occlusions involving the intracranial internal carotid or M1- M2-segments middle cerebral arteries, premorbid modified Rankin Scale score 0 2 treatment 24...
BackgroundLong-term data showing the benefits of endovascular thrombectomy for stroke with large infarct are scarce. The TENSION trial showed safety and efficacy in patients ischaemic at 90 days. We aimed to investigate 12 months who were enrolled trial.MethodsTENSION was an open-label, blinded endpoint, randomised done 40 hospitals across Europe one hospital Canada. included (aged ≥18 years) acute due vessel occlusion anterior circulation had a infarct, as indicated by Alberta Stroke...
Portal hypertension is a syndrome caused by increased resistance in the portohepatic circulation and an increase splanchnic vein blood supply. In normal liver, difference between pressures portal free hepatic veins or right atrium usually does not exceed 5 mm Hg. defined as gradient larger than 6 Hg, but clinical complications seem to occur only when pressure exceeds 10–12 Hg. Wedged measurement has two components. The component transmitted from sinusoids, systemic central veins. It that...
Rationale The benefit of thrombectomy in patients with intracranial large vessel occlusion the anterior circulation has been shown selected previous randomized controlled trials, but extended ischemic lesions were excluded majority these trials. TENSION aims to demonstrate efficacy and safety an time window (up 12 h from onset or last seen well). Design is investigator-initiated, controlled, open label, blinded endpoint, European, two-arm, postmarket study compare effectiveness as compared...
Ischemic stroke is a leading cause of death and disability worldwide. Much the long-term occurs in patients with Emergent Large Vessel Occlusion (ELVO). In fact, these patients, occlusion major intracerebral artery results large area brain injury often resulting
Background Recent randomized controlled trials show benefit of thrombectomy for large vessel occlusion in stroke. Real‐world data aid assessing reproducibility outcomes outside clinical trials. The Trevo Retriever Registry is a multicenter, international, prospective study designed to assess cohort patients. Methods and Results database patients with treated the device as first device. primary end point revascularization based on modified Thrombolysis Cerebral Infarction score secondary...
Background and Purpose: Intra-arterial thrombolysis as an adjunct to mechanical thrombectomy is increasingly being considered enhance reperfusion in acute ischemic stroke patients. may increase the risk of post-thrombectomy intracerebral hemorrhage (ICH) certain patient subgroups. Methods: We analyzed patients treated with a multicenter registry. The occurrence any (asymptomatic symptomatic) ICH was ascertained using standard definition requiring serial neurological examinations computed...
In patients with large ischemic stroke, thrombectomy within 12 hours after onset was superior to best medical treatment in reducing 90-day functional disability irrespective of the collateral status on single-phase CT angiography images.
BACKGROUND: Recent randomized trials demonstrated the beneficial effect of endovascular therapy in patients with low Alberta Stroke Program Early Computed Tomography Score. Despite large follow-up infarct volumes, a significantly increased rate good functional outcomes was observed, challenging role volume as predictive imaging marker. This analysis evaluates extent to which effects thrombectomy on are explained by (1) and (2) early neurological status stroke METHODS: TENSION trial conducted...
Background There is a paucity of data regarding mechanical thrombectomy (MT) in distal arterial occlusions (DAO). We aim to evaluate the safety and efficacy MT patients with DAO compare their outcomes proximal occlusion (PAO) strokes. Methods The Trevo Registry was prospective open-label registry including 2008 from 76 sites across 12 countries. Patients were categorized into: PAO: intracranial ICA, MCA–M1; DAO: MCA–M2, MCA–M3, ACA, PCA. Baseline outcome variables compared PAO vs pre-morbid...
First pass effect (FPE), defined as near-total/total reperfusion of the territory (modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3) occluded artery after a single thrombectomy attempt (single pass), has been associated with superior safety and efficacy outcomes than patients not experiencing FPE.To characterize clinical features, incidence, predictors FPE anterior posterior circulation among enrolled Trevo Registry.Data were analyzed from Retriever Registry. Univariate...
OBJECTIVE. The purpose of the study was to evaluate long-term clinical efficacy Doppler sonography in revealing failure transjugular intrahepatic portosystemic shunts (TIPS).
In primary aldosteronism, adrenal venous sampling (AVS) is essential for subtype differentiation as it evaluates aldosterone secretion from both adrenals. Selectivity of assessed by the ratio cortisol concentrations in blood and inferior vena cava (C(adrenal)/C(ivc)). Since criteria selective differ among reported literature, we performed a study to evaluate influence different selectivity on AVS results.Reports were screened retrospectively. All with cosyntrophin infusion. Reports...
Introduction and Aim: Hepatic encephalopathy (HE) is a common complication of transjugular intrahepatic portosystemic shunting (TIPS). It associated with reduced quality life poor prognosis. The aim this study was to compare two groups patients who did not develop overt HE after TIPS. We looked for differences between these before TIPS.A 895 conducted based on retrospective analysis clinical data. Data analyzed using Fisher's exact test, Chi-square, Mann Whitney unpaired t-test logistic...
The composition of intra-arterial clots might influence the efficacy mechanical thrombectomy (MT) in ischemic stroke (IS) due to acute occlusions within large cerebral arteries. aims were assess factors associated with blood clot structure and impact thromboembolus on MT using stent-retrievers patients artery IS anterior circulation.
Background and purpose The of this study was to evaluate the safety effectiveness mechanical thrombectomy (MT) in patients with acute ischaemic stroke related isolated primary posterior cerebral artery (PCA) occlusions amongst enrolled multicentre post‐market Trevo Registry. Method Amongst 2008 Registry due large vessel occlusion treated by MT, 22 (1.1%) [10 females (45.5%), mean age 66.2 ± 14.3 years (range 28–91)] had a PCA [17 P1 (77.3%) five P2 (22.7%)]. Recanalization after first...