A5068258055- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Neurosurgical Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Peripheral Artery Disease Management
- Cerebrovascular and genetic disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cerebrospinal fluid and hydrocephalus
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Botulinum Toxin and Related Neurological Disorders
- Pituitary Gland Disorders and Treatments
- MRI in cancer diagnosis
- Neurobiology of Language and Bilingualism
- Electroconvulsive Therapy Studies
- Antifungal resistance and susceptibility
- Electronic Health Records Systems
- Older Adults Driving Studies
- Syphilis Diagnosis and Treatment
- Marine Toxins and Detection Methods
Health and Education Research Management and Epidemiologic Services (United States)
2023
Tufts Medical Center
2021-2023
St. Mary's Medical Center
2010-2022
Collaborative Neuroscience Network
2021
Dimensional Imaging (United Kingdom)
2020
Neurosciences Institute
2019
Australian Library and Information Association
2019
Delray Medical Center
2019
Johns Hopkins University
2019
St. Mary's Medical Center
2019
We report here that the level of endothelin-1 (ET-1) mRNA from bovine aortic endothelial cells grown in vitro is rapidly (within 1 h exposure) and significantly (fivefold) decreased response to fluid shear stress physiological magnitude. The downregulation ET-1 occurs a dose-dependent manner exhibits saturation above 15 dyn/cm2. decrease complete prior detectable changes cell shape maintained throughout following alignment direction blood flow. Peptide levels secreted into media are also...
Advanced imaging has been increasingly used for patient selection in endovascular stroke therapy. The impact of modality on therapy clinical outcomes extended time window remains to be defined. We aimed study this relationship and compare it that noted early-treated patients. Patients from a prospective multicentric registry (n=2008) with occlusions involving the intracranial internal carotid or M1- M2-segments middle cerebral arteries, premorbid modified Rankin Scale score 0 2 treatment 24...
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In this study, 39 patients with PD and 25 control subjects without neurologic disease completed testing in a driving simulator. had more total collisions on the simulator than (t = -3.7, p < 0.01). patients, were associated Hoehn Yahr stage (chi(2) 12.4, 0.006) correlated Unified Parkinson's Disease Rating Scale score (r 0.5,
Subarachnoid hemorrhage (SAH) is a devastating condition. It carries high mortality rate, with 12% of patients dying before reaching the hospital. Aside from its neurological morbidities, SAH associated significant medical complications. Cardiac manifestations are common and can impact morbidity in patients. This article will discuss cardiac SAH.
Background There is a paucity of data regarding mechanical thrombectomy (MT) in distal arterial occlusions (DAO). We aim to evaluate the safety and efficacy MT patients with DAO compare their outcomes proximal occlusion (PAO) strokes. Methods The Trevo Registry was prospective open-label registry including 2008 from 76 sites across 12 countries. Patients were categorized into: PAO: intracranial ICA, MCA–M1; DAO: MCA–M2, MCA–M3, ACA, PCA. Baseline outcome variables compared PAO vs pre-morbid...
Mycophenolate mofetil is an immunosuppressive agent that inhibits the de novo pathway of guanosine nucleotide synthesis critical for B- and T-lymphocyte proliferation.1 It absorbed rapidly undergoes presystemic metabolism to mycophenolic acid-a potent, selective, noncompetitive, reversible inhibitor inosine monophosphate dehydrogenase.2 We present a patient with severe refractory myasthenia gravis (MG) who experienced excellent response mycophenolate mofetil. A 14-year-old girl initially...
Brain infarction due to small vessel cerebrovascular disease (SVCD)—also known as infarct (SVI) or “lacunar” stroke—accounts for 20% 25% of all ischemic strokes. Historically, SVIs have been associated with a favorable short-term prognosis. However, studies over the years demonstrated that SVCD/SVI is perhaps more complex and less benign phenomenon than generally presumed. The currently employed diagnostic therapeutic strategies are based upon historical contemporary perceptions SVCD/SVI....
ABSTRACT BACKGROUND The incidence of thromboembolic events associated with Neuroform stent™ (Boston Scientific Target, Fremont, CA) is known from previous studies but there are uncertainties scale. PURPOSE To report our rate ischemic stent™. METHODS Consecutive patients treated for intracranial aneurysms were prospectively enrolled January 2003 to August 2006. Thromboembolic as well clinical outcomes measured. Mean follow‐up was 12 months. RESULTS Successful stent deployment achieved in...
The clinical efficacy of mechanical thrombectomy has been unequivocally demonstrated in multiple randomized trials. However, these studies were performed carefully selected centers and utilized strict inclusion criteria.We aimed to assess the effectiveness a prospective registry.A total 2008 patients from 76 sites across 12 countries enrolled open-label registry. Patients categorized into corresponding cohorts SWIFT-Prime, DAWN, DEFUSE 3 trials according basic demographic criteria without...
The effect of time from stroke onset to thrombectomy in the extended window remains poorly characterized.We aimed analyze relationship between treatment and clinical outcomes early versus windows.Proximal anterior circulation occlusion patients a multicentric prospective registry were categorized into (≤6 h) or (>6-24 window. Patients with baseline National Institutes Health Stroke Scale (NIHSS) ≥ 10 intracranial internal carotid artery middle cerebral artery-M1-segment pre-morbid modified...
Background Intracranial atherosclerotic disease (ICAD) is a common cause of posterior circulation acute ischemic stroke. We aimed to compare baseline characteristics, recanalization rates, and clinical outcomes in patients with basilar occlusion due underlying ICAD other causes occlusion. Methods The Trevo Registry (ClinicalTrials.gov Identifier: NCT02040259) was prospective open‐label mechanical thrombectomy registry that included 2008 from 76 sites across 12 countries. For secondary...
L’objectif de ce travail est d’étudier et concevoir un onduleur solaire, d’une puissance sortie d’environ 1 kVA avec une tension d’entrée 12 VDC à onde purement sinusoïdale 230 VAC fréquence 50 Hz. Les améliorations apportées l’onduleur se situent essentiellement au niveau la commande, tout d’abord, génération sinusoïdale, mais également surveillance sortie, ainsi que température des interrupteurs électroniques, qui permettrait préserver le bon fonctionnement l’onduleur. Bien conscient sujet...
✓Nelson syndrome (NS) is a rare clinical manifestation of an enlarging pituitary adenoma that can occur following bilateral adrenal gland removal performed for the treatment Cushing disease. It characterized by excess adreno-corticotropin secretion and hyperpigmentation skin mucus membranes. The authors present comprehensive review pathophysiology, diagnosis, management NS. Corticotroph adenomas in NS remain challenging tumors lead to significant rates morbidity mortality. A better...
A 49-year-old man presented with a five-week history of worsening confusion, agitation, and bizarre behavior. According to his mother sister, who live him, he had inexplicably jumped out bed one day complained injuring back. The pain apparently resolved within several days. Two weeks later, again just after awakening, experienced period lasting about 15 min. latest episode occurred three days previously included vivid hallucinations--at various times, seemed believe that was talking brother...
<h3>Introduction</h3> Idiopathic Normal Pressure Hydrocephalus (NPH) is a potentially reversible form of dementia and one the most common forms adult hydrocephalus. Treatment has involved ventriculo-peritoneal shunt surgery (VPS) with associated risk infection, revision, over-drainage. We recently described first percutaneous transfemoral deployment an endovascular CSF (eShunt® System; CereVasc, Inc., Auburndale, MA, USA), via transvenous approach to treat communicating hydrocephalus...