Adrian Parry‐Jones
A5016721842- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Clinical practice guidelines implementation
- S100 Proteins and Annexins
- Spinal Hematomas and Complications
- Cerebrospinal fluid and hydrocephalus
- Dementia and Cognitive Impairment Research
- Cancer-related gene regulation
- Thermal Regulation in Medicine
- Long-Term Effects of COVID-19
- Advanced Neuroimaging Techniques and Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Chronic Kidney Disease and Diabetes
- Zebrafish Biomedical Research Applications
- Mitochondrial Function and Pathology
University of Manchester
2016-2025
Manchester Academic Health Science Centre
2013-2025
Salford Royal NHS Foundation Trust
2015-2024
National Health Service
2015-2024
Salford Royal Hospital
2012-2024
Cardiovascular Research Center
2019-2024
Northern Health and Social Care Trust
2023-2024
NIHR Manchester Biomedical Research Centre
2024
University of Salford
2014-2022
Campbell Collaboration
2021
Early control of elevated blood pressure is the most promising treatment for acute intracerebral haemorrhage. We aimed to establish whether implementing a goal-directed care bundle incorporating protocols early intensive lowering and management algorithms hyperglycaemia, pyrexia, abnormal anticoagulation, implemented in hospital setting, could improve outcomes patients with spontaneous
BackgroundAntiplatelet therapy reduces the risk of major vascular events for people with occlusive disease, although it might increase intracranial haemorrhage. Patients surviving commonest subtype haemorrhage, intracerebral are at both haemorrhagic and events, but whether antiplatelet can be used safely is unclear. We aimed to estimate relative absolute effects on recurrent haemorrhage this exceed any reduction events.MethodsThe REstart or STop Antithrombotics Randomised Trial (RESTART) was...
Intracerebral hemorrhage is the most serious type of stroke, leading to high rates severe disability and mortality. Hematoma expansion an independent predictor poor functional outcome a compelling target for intervention. For decades, randomized trials aimed at decreasing hematoma through single interventions have failed meet their primary outcomes statistically significant improvement in neurological outcomes. A wide range evidence suggests that ultra-early bundled care, with multiple...
The proinflammatory cytokine IL-1 (interleukin-1) has a deleterious role in cerebral ischemia, which is attenuated by receptor antagonist (IL-1Ra). induces peripheral inflammatory mediators, such as interleukin-6, are associated with worse prognosis after ischemic stroke. We investigated whether subcutaneous IL-1Ra reduces the response acute stroke.SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist Ischemic Stroke) was single-center, double-blind, randomized, placebo-controlled...
<h3>Objective:</h3> In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non–vitamin K antagonist oral anticoagulation–related ICH (NOAC-ICH) vitamin antagonist–associated (VKA-ICH). <h3>Methods:</h3> We all-cause mortality within 90 days for NOAC-ICH VKA-ICH using a Cox proportional hazards model adjusted age; sex; baseline Glasgow Coma Scale score, location, log...
To compare intracerebral hemorrhage (ICH) volume and clinical outcome of non-vitamin K oral anticoagulants (NOAC)-associated ICH to warfarin-associated ICH.In this multicenter cross-sectional observational study patients with anticoagulant-associated ICH, consecutive NOAC-ICH were compared those warfarin-ICH selected from a population 344 ICH. was measured by an observer blinded details. Outcome measures adjusted for confounding factors.We 11 52 warfarin-ICH. The median 2.4 mL (interquartile...
Objective Anticoagulation reversal, intensive blood pressure lowering, neurosurgery, and access to critical care might all be beneficial in acute intracerebral hemorrhage (ICH). We combined implemented these as the “ABC” hyperacute bundle sought determine whether implementation was associated with lower case fatality. Methods The ABC from June 1, 2015 May 31, 2016. Key process targets were set, a registry captured consecutive patients. compared 30‐day fatality before, during, after...
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding therapy. Brain imaging features and cerebral small vessel diseases (such as microbleeds) are associated greater risks haemorrhage. We did subgroup analyses to explore whether these brain modify effects
Objective There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA‐ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was compare case fatality with different reversal strategies. Methods We pooled individual ICH patient data from 16 stroke registries 9 countries (n = 10 282), of whom 1,797 (17%) were VKA. After excluding 250 patients international...
Various grading scores to predict survival after intracerebral hemorrhage (ICH) have been described. We aimed test the accuracy and clinical usefulness of 3 well-known (original ICH score, modified scale) in a large unselected cohort typical patients.A total 1364 cases were referred our center from January 1, 2008, October 17, 2010. Clinical details prospectively recorded, first computed tomography brain scan was retrospectively reviewed determine volume location identify intraventricular...
Early hematoma growth (EHG) occurs in about one third of patients with spontaneous intracerebral hemorrhage. The main aim this study was to investigate the potential plasma C-reactive protein (CRP) for predicting EHG after acute hemorrhage.Plasma CRP measured within 6 hours onset (median, 120 minutes) 399 primary or vitamin K antagonist-associated hemorrhage and without recent infection. Computed tomography brain scans were performed at baseline repeated 24 22 hours). outcome EHG, defined as...
<h3>Objectives:</h3> We examined the C-reactive protein (CRP) response after spontaneous intracerebral hemorrhage (sICH) and its relationship to outcome. additionally characterized early brain localization of CRP. <h3>Methods:</h3> In this prospective, multicenter, international, collaborative, longitudinal study with cross-sectional immunohistochemical analysis tissue, 223 patients (M/F: 132/91) were recruited during 2010 calendar year. CRP was evaluated at admission (median 93 minutes from...
Intracerebral haemorrhage (ICH) accounts for half of the disability-adjusted life years lost due to stroke worldwide. Care pathways acute result in rapid identification ICH, but its management can prove challenging because no individual treatment has been shown definitively improve outcome. Nonetheless, unit care improves outcome after patients benefit from interventions prevent complications, blood pressure lowering appears safe and might have a modest benefit, implementing bundle...
Background and Purpose: The causes of recurrent ischemic stroke despite anticoagulation for atrial fibrillation are uncertain but might include small vessel occlusion. We investigated whether magnetic resonance imaging markers cerebral disease (SVD) associated with risk during follow-up in patients anticoagulated after recent or transient attack. Methods: analyzed data from a prospective multicenter inception cohort study attack (CROMIS-2 [Clinical Relevance Microbleeds Stroke Study]). rated...
RNA sequencing of cerebral hematoma myeloid cells reveals a two-stage functional and metabolic program associated with recovery.
The benefits of involving those with lived experience in the design and development health technology are well recognized, reporting co-design best practices has increased over past decade. However, it is important to recognize that methods protocols behind patient public involvement vary depending on population accessed. This especially when considering individuals living cognitive impairments, such as dementia, who likely have needs experiences unique their capabilities. We worked...