Octávio Marques Pontes‐Neto
A5027377669- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Neurosurgical Procedures and Complications
- Cardiovascular Health and Disease Prevention
- Advanced Neuroimaging Techniques and Applications
- Obstructive Sleep Apnea Research
- Advanced MRI Techniques and Applications
- Cardiovascular and Diving-Related Complications
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disorders and Treatments
- Transcranial Magnetic Stimulation Studies
- Spatial Neglect and Hemispheric Dysfunction
- Functional Brain Connectivity Studies
- Vestibular and auditory disorders
- Cerebrospinal fluid and hydrocephalus
- Tracheal and airway disorders
- Health, Nursing, Elderly Care
- Cerebral Venous Sinus Thrombosis
- Dysphagia Assessment and Management
- Peripheral Artery Disease Management
- Ophthalmology and Eye Disorders
Universidade de São Paulo
2016-2025
Instituto de Neurociências e Comportamento
2013-2025
Universidade de Ribeirão Preto
2014-2025
Clinics Hospital of Ribeirão Preto
2016-2025
The George Institute for Global Health
2017-2024
UNSW Sydney
2017-2024
Sichuan University
2024
The University of Sydney
2017-2024
NIHR Leicester Biomedical Research Centre
2024
Hospital Universitário da Universidade de São Paulo
2023
The effectiveness of endovascular therapy in patients with stroke caused by basilar-artery occlusion has not been well studied.We randomly assigned within 6 hours after the estimated time onset a due to occlusion, 1:1 ratio, receive or standard medical care. primary outcome was favorable functional outcome, defined as score 0 3 on modified Rankin scale (range, 6, indicating no disability, moderate and death) at 90 days. safety outcomes were symptomatic intracranial hemorrhage days initiation...
Thrombolytic therapy for acute ischemic stroke with a lower-than-standard dose of intravenous alteplase may improve recovery along reduced risk intracerebral hemorrhage.Using 2-by-2 quasi-factorial open-label design, we randomly assigned 3310 patients who were eligible thrombolytic (median age, 67 years; 63% Asian) to low-dose (0.6 mg per kilogram body weight) or the standard (0.9 kilogram); underwent randomization within 4.5 hours after onset stroke. The primary objective was determine...
<i>Background:</i> We aimed to validate three widely used scales in stroke research a multiethnic Brazilian population. <i>Methods:</i> The National Institutes of Health Stroke Scale (NIHSS), modified Rankin (mRS) and Barthel Index (BI) were translated, culturally adapted applied by two independent investigators. mRS was with or without previously validated structured interview. Interobserver agreement (kappa statistics) intraclass correlation coefficients calculated....
Hematoma expansion is a potentially modifiable predictor of poor outcome following an acute intracerebral hemorrhage (ICH). The ability to identify patients with ICH who are likeliest experience hematoma and therefore benefit from expansion-targeted treatments remains unmet need. Hypodensities within detected by noncontrast computed tomography (NCCT) have been suggested as expansion.To determine whether hypodense regions, irrespective their specific patterns, associated in ICH.We analyzed...
Sobre este Documento O Brasil é um país continental de extrema diversidade quanto a clima e condições ambientais, densidade populacional, desenvolvimento econômico características raciais culturais. Uma das dez economias mais ricas do mundo, o também dos países desiguais: segundo Banco Mundial, está entre os maior Índice Gini, uma medida da desigualdade distribuição renda (https://data.worldbank.org/indicator/SI.POV.GINI). possui SUS, maiores sistemas públicos saúde com [...]
Randomized trials involving patients with stroke have established that outcomes are improved the use of thrombectomy for large-vessel occlusion. These were performed in high-resource countries and had limited effects on medical practice low- middle-income countries.
Early control of elevated blood pressure is the most promising treatment for acute intracerebral haemorrhage. We aimed to establish whether implementing a goal-directed care bundle incorporating protocols early intensive lowering and management algorithms hyperglycaemia, pyrexia, abnormal anticoagulation, implemented in hospital setting, could improve outcomes patients with spontaneous
Sobre estas estatísticas Esta é a edição de 2021 da Estatística Cardiovascular – Brasil , um esforço multi-institucional para fornecer periodicamente informação atualizada sobre epidemiologia das DCV e AVC no Brasil. Este relatório incorpora oficiais fornecidas pelo Ministério Saúde brasileiro outros órgãos governamentais, projeto GBD liderado IHME Universidade Washington, além dados gerados por outras fontes estudos científicos, como coortes registros, as seus fatores risco. [...]
SOBRE ESTE DOCUMENTO A publicação Estatística Cardiovascular – Brasil tem por objetivo fornecer uma compilação anual dos dados e das pesquisas sobre a epidemiologia DCV no Brasil. Este documento congrega as estatísticas oficiais do Ministério da Saúde outras entidades governamentais ao lado de projeto GBD, coordenado pelo IHME Universidade Washington. Além disso, incorpora derivados várias fontes estudos científicos, inclusive coortes registros, relacionados às fatores risco [...]
Background and Purpose— Stroke is the leading cause of death in Brazil. This community-based study assessed lay knowledge about stroke recognition treatment risk factors for cerebrovascular diseases activation emergency medical services Methods— The was conducted between July 2004 December 2005. Subjects were selected from urban population transit public places 4 major Brazilian cities: São Paulo, Salvador, Fortaleza, Ribeirão Preto. Trained students, residents, neurologists interviewed...
The role of supine positioning after acute stroke in improving cerebral blood flow and the countervailing risk aspiration pneumonia have led to variation head clinical practice. We wanted determine whether outcomes patients with ischemic could be improved by patient lying flat (i.e., fully back horizontal face upwards) during treatment increase perfusion.In a pragmatic, cluster-randomized, crossover trial conducted nine countries, we assigned 11,093 (85% strokes were ischemic) receive care...
<h3>Objective:</h3> To investigate whether the topography of dilated perivascular spaces (DPVS) corresponds with markers particular small-vessel diseases such as cerebral amyloid angiopathy and hypertensive vasculopathy. <h3>Methods:</h3> Patients were recruited from an ongoing single-center prospective longitudinal cohort study patients evaluated in a memory clinic. All underwent structural, high-resolution MRI, had clinical assessment performed within 1 year scan. DPVS rated basal ganglia...
Abstract Introduction The Boston criteria are the basis for a noninvasive diagnosis of cerebral amyloid angiopathy (CAA) in setting lobar intracerebral hemorrhage (ICH). We assessed accuracy these individuals with microbleeds (MBs) without ICH. Methods identified aged >55 years having brain magnetic resonance imaging (MRI) and pathological assessment CAA single academic hospital community‐based population (Framingham Heart Study [FHS]). determined positive predictive value (PPV) both...
Background Stroke is one of the major public health challenges in middle-income countries. Brazil world's sixth largest economy but was clearly behind milestones fight against stroke, which leading cause death and disability country. Nevertheless, many initiatives are now reshaping stroke prevention, care, rehabilitation Aims The present article discusses evolution care over last decade. Methods We describe main characteristics before 2008; a pilot study Southern Brazilian city between 2008...
<h3>Background</h3> There is growing evidence regarding the importance of contextual factors for patient/staff outcomes and likelihood successfully implementing safety improvement interventions such as checklists; however, certain literature gaps still remain—for example, lack research examining interactive effects constructs on outcomes. This study has addressed some these gaps, together with adding to our understanding how context influences safety. <h3>Purpose</h3> The impact staff...
Among patients with a transient ischemic attack or minor strokes, those ipsilateral atherosclerotic stenosis of cervicocranial vasculature have the highest risk recurrent vascular events.
The publication Cardiovascular Statistics – Brazil aims to provide an annual compilation of data and research on the epidemiology CVDs in Brazil. report integrates official statistics from Brazilian Ministry Health other governmental entities alongside GBD project, coordinated by IHME at University Washington. Additionally, it incorporates derived various sources scientific studies, including cohorts registries, that relate their associated risk factors. This is intended for a wide range...
Acute respiratory distress syndrome develops commonly in critically ill patients response to an injurious stimulus. The prevalence and risk factors for development of acute after spontaneous intracerebral hemorrhage have not been reported. We sought determine the hemorrhage, characterize its development, assess impact on patient outcomes.Retrospective cohort study at two academic centers.We included consecutive presenting from June 1, 2000, November 2010, with requiring mechanical...
Rationale Controversy exists over the optimal dose of intravenous (iv) recombinant tissue plasminogen activator (rt-PA) and degree blood pressure (BP) control in acute ischaemic stroke (AIS). Asian studies suggest low-dose (0·6 mg/kg) is more efficacious than standard-dose (0·9 iv rt-PA, guidelines recommend reducing systolic BP to <185 mmHg before <180 after use despite observational indicating better outcomes at much lower (<140 mmHg) levels this patient group. Aims The study aims...
The ability of present-day etiologic stroke classification systems to generate subtypes with discrete characteristics is not known.To test the hypothesis that subtyping identifies different disease processes can be recognized through their clinical courses.We performed a head-to-head evaluation Causative Classification Stroke (CCS), Trial Org 10172 in Acute Treatment (TOAST), and ASCO (A for atherosclerosis, S small-vessel disease, C cardiac source, O other cause) clinical, imaging,...
Noncontrast computed tomographic (CT) hypodensities have been shown to be associated with hematoma expansion in intracerebral hemorrhage (ICH), but their impact on functional outcome is yet determined. We evaluated whether baseline noncontrast CT are poor clinical outcome.We performed a retrospective review of prospectively collected cohort consecutive patients primary ICH presenting single academic medical center between 1994 and 2016. The presence was assessed by 2 independent raters the...