A5016635966- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- Cerebrovascular and genetic disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Dementia and Cognitive Impairment Research
- Neurological Complications and Syndromes
- Neurological and metabolic disorders
- Spinal Hematomas and Complications
- Kruppel-like factors research
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- MRI in cancer diagnosis
Leiden University Medical Center
2016-2025
Harvard University
2012-2017
Massachusetts General Hospital
2012-2017
Carmel Medical Center
2017
Université Paris Cité
2017
Inserm
2017
Centre Hospitalier Sainte-Anne
2017
Radboud University Nijmegen
2016
Radboud University Medical Center
2016
Alrijne Ziekenhuis
2016
<h3>Importance</h3> Cerebral amyloid angiopathy–related inflammation (CAA-ri) is an important diagnosis to reach in clinical practice because many patients with the disease respond immunosuppressive therapy. Reliable noninvasive diagnostic criteria for CAA-ri would allow some avoid risk of brain biopsy. <h3>Objective</h3> To test sensitivity and specificity neuroimaging-based CAA-ri. <h3>Design, Setting, Participants</h3> We modified previously proposed clinicoradiological retrospectively...
To assess MRI-visible enlarged perivascular spaces (EPVS) burden and different topographical patterns (in the centrum semiovale [CSO] basal ganglia [BG]) in 2 common microangiopathies: cerebral amyloid angiopathy (CAA) hypertensive arteriopathy (HA).Consecutive patients with spontaneous intracerebral hemorrhage (ICH) from a prospective MRI cohort were included. Small vessel disease markers, including microbleeds (CMBs), cortical superficial siderosis (cSS), white matter hyperintensities...
To identify different white matter hyperintensity (WMH) patterns between 2 hemorrhage-prone cerebral small vessel diseases (SVD): amyloid angiopathy (CAA) and hypertensive arteriopathy (HA).
Objective We hypothesized that vascular amyloid contributes to chronic brain ischemia, therefore burden measured by Pittsburgh compound B retention on positron emission tomography (PiB PET) would correlate with the extent of magnetic resonance imaging (MRI) white matter hyperintensities (WMH; or leukoaraiosis) in patients high deposition (cerebral angiopathy [CAA]) but not parenchymal (Alzheimer disease [AD]; mild cognitive impairment [MCI]) healthy elderly (HE) subjects. Methods Forty‐two...
Lobar microbleeds suggestive of cerebral amyloid angiopathy (CAA) are often identified on MRI in the absence lobar intracerebral hemorrhage (ICH). We compared baseline characteristics and risk subsequent ICH among such patients to those presenting with CAA-related ICH.Clinical data (demographics, factors), apolipoprotein E genotype, neuroimaging markers CAA severity (microbleed counts, leukoaraiosis volume), clinical outcomes (incidence rates death during a mean follow-up 5.3±3.8 years) were...
Abstract Introduction The Boston criteria are the basis for a noninvasive diagnosis of cerebral amyloid angiopathy (CAA) in setting lobar intracerebral hemorrhage (ICH). We assessed accuracy these individuals with microbleeds (MBs) without ICH. Methods identified aged >55 years having brain magnetic resonance imaging (MRI) and pathological assessment CAA single academic hospital community‐based population (Framingham Heart Study [FHS]). determined positive predictive value (PPV) both...
In order to explore the mechanisms of cortical superficial siderosis (cSS) multifocality and its clinical implications for recurrent intracerebral hemorrhage (ICH) risk in patients with cerebral amyloid angiopathy (CAA), we used a new rating method that developed specifically evaluate cSS extent at spatially separated foci.Consecutive CAA-related ICH according Boston criteria from single-center prospective cohort were analyzed. The score assesses (total range 0-4) showed excellent interrater...
Prion-like transmission of amyloid-ß through cadaveric dura, decades after neurosurgical procedures, has been hypothesized as an iatrogenic cause cerebral amyloid angiopathy (CAA). We investigated new and previously described patients to assess the clinical profile, radiological features, outcome this presumed CAA-subtype (iCAA). Patients were collected from our prospective lobar hemorrhage CAA database (n=251) with presenting hospital between 2008 2022. In addition, we identified iCAA 2...
Hematoma expansion is an important determinant of outcome in spontaneous intracerebral hemorrhage (ICH) due to small vessel disease (SVD), but the association between severity underlying SVD and extent bleeding at acute phase unknown date.To investigate key magnetic resonance imaging (MRI) markers (as per Standards for Reporting Vascular Changes on Neuroimaging [STRIVE] guidelines) hematoma volume patients with lobar or deep ICH.Analysis data collected from 418 consecutive admitted primary...
To investigate CSF biomarkers in presymptomatic and symptomatic mutation carriers with hereditary cerebral hemorrhage amyloidosis-Dutch type (HCHWA-D), a model for sporadic amyloid angiopathy, to determine the earliest deposited form of β-amyloid (Aβ).HCHWA-D controls were enrolled cross-sectional EDAN (Early Diagnosis Amyloid Angiopathy Network) study. The HCHWA-D group was divided into previous intracerebral carriers. concentrations Aβ40, Aβ42, total tau, phosphorylated tau181 proteins...
Neurofilament light chain (NFL) is a biomarker for neuroaxonal damage and glial fibrillary acidic protein (GFAP) reactive astrocytosis. Both processes occur in cerebral amyloid angiopathy (CAA), but studies investigating the potential of NFL GFAP as markers CAA are lacking. We aimed to investigate biomarkers astrocytosis CAA.
Abstract Background and purpose Patients who underwent red blood cell (RBC) transfusion from donors later developed multiple spontaneous intracerebral hemorrhages (ICHs) have recently been identified to increased risk of ICH themselves. This was hypothesized be related iatrogenic cerebral amyloid angiopathy (iCAA) transmission. Two cases are presented had RBC as an infant with CAA at a relatively young age decades later. Method Cases were by prospectively asking all patients our outpatient...
Cerebral microinfarcts (CMI) are important contributors to vascular cognitive impairment. Magnetic resonance imaging diffusion-weighted (DWI) hyperintensities have been suggested represent acute CMI. We aim describe a mathematical method for estimating total number of CMI based on the presence incidental DWI lesions.We reviewed magnetic scans subjects with decline, cognitively normal and previously reported past intracerebral hemorrhage (ICH). Based temporal spatial characteristics lesions,...
To determine whether hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D), a monogenetic disease model for the sporadic variant of amyloid angiopathy (sCAA), has comparable recurrent intracerebral (ICH) risk and mortality after first symptomatic ICH.We included patients HCHWA-D from Leiden University Medical Center sCAA Massachusetts General Hospital in cohort study. Baseline characteristics, recurrence, short- long-term were compared. Hazard ratios (HRs) adjusted age sex...
Background We aimed to describe neuroimaging features, clinical profiles and long-term outcomes in patients with iatrogenic cerebral amyloid angiopathy (iCAA). Methods performed a systematic literature search for case series of iCAA included individual their longitudinal data this pooled cohort study. Patients meeting modified version the Queen Square criteria were included. Baseline follow-up MRIs centrally analysed markers CAA using validated rating scales. Results 51 (68.6% male, median...
Iatrogenic cerebral amyloid angiopathy (iCAA) is a recently identified clinico-neuroradiological syndrome associated with medical procedures, particularly neurosurgical treatments involving cadaveric dura mater (e.g., Lyodura). iCAA can manifest as intracerebral hemorrhages, focal seizures, and cognitive impairment, the risk following exposure currently unknown. We aim to evaluate of developing in patients who underwent childhood treatment Lyodura compared those did not. This retrospective...
Knowledge on the short-term progression of cerebral amyloid angiopathy (CAA) is important for clinical practice and design treatment trials. We investigated 1-year CAA-related MRI markers in sporadic (sCAA) Dutch-type hereditary (D-CAA). Participants were included from 2 prospective cohort studies. 3T-MRI was performed at baseline after 1 year. assessed macrobleeds, microbleeds (CMBs), cortical superficial siderosis (cSS), convexity subarachnoid hemorrhages (cSAHs), white matter...
BACKGROUND: The temporal ordering of biomarkers for cerebral amyloid angiopathy (CAA) is important their use in trials and the understanding pathological cascade CAA. We investigated presence abnormality most common largest (pre)symptomatic Dutch-type hereditary CAA (D-CAA) cohort to date. METHODS: included cross-sectional data from participants with D-CAA controls without CAA-related small vessel disease markers on 3T-MRI, cerebrovascular reactivity functional 7T-MRI (fMRI) amyloid-β 40 42...
Iron accumulation has been linked to neuronal injury following cerebral ischemia. In animals, a hypointense signal on T2*-weighted (T2*-w) MRI correlated with iron deposits in remote brain regions ischemic stroke. We aim assess whether such changes are present structures stroke humans.We analyzed T2*-w images of 36 patients unilateral and healthy controls. Regions interest (ROIs) consisted the thalamus, putamen, globus pallidus, caudate nucleus white matter. To quantify intensity ROIs...
Abstract Background The diagnosis of probable cerebral amyloid angiopathy (CAA) is currently mostly based on characteristics brain MRI. Blood biomarkers would be a cost-effective, easily accessible diagnostic method that may complement by MRI and aid in monitoring disease progression. We studied the potential plasma Aβ38, Aβ40, Aβ42 patients with hereditary Dutch-type CAA (D-CAA) sporadic (sCAA). Methods All Aβ peptides were quantified immunoassays discovery cohort (11 presymptomatic D-CAA...