A5071237195- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neurological Disorders and Treatments
- Neurosurgical Procedures and Complications
- Advanced Neuroimaging Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Leprosy Research and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and genetic disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Cerebrospinal fluid and hydrocephalus
- Cancer-related molecular mechanisms research
- Tuberculosis Research and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Mycobacterium research and diagnosis
- Child and Adolescent Psychosocial and Emotional Development
- Flavonoids in Medical Research
- Biochemical effects in animals
- Brain Tumor Detection and Classification
- Infectious Diseases and Tuberculosis
- Advanced MRI Techniques and Applications
- Traditional Chinese Medicine Studies
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2025
Jiangxi Provincial Academy of Medical Sciences
2025
Capital Medical University
2012-2025
Beijing Shijitan Hospital
2025
Chengdu Medical College
2019-2023
Hubei University of Science and Technology
2018-2023
Massachusetts General Hospital
2015-2021
Harvard University
2015-2021
Yunnan Center for Disease Control And Prevention
2013-2021
<h3>Objective</h3> To determine whether MRI-based cerebral small vessel disease (CSVD) burden assessment, in addition to clinical and CT data, improved prediction of cognitive impairment after spontaneous intracerebral hemorrhage (ICH). <h3>Methods</h3> We analyzed data from ICH survivors enrolled a single-center prospective study. employed 3 validated CSVD scores: global, amyloid angiopathy (CAA)–specific, hypertensive arteriopathy (HTNA)–specific. quantified performance by administering...
Hemodynamic disturbance in cerebral blood flow (CBF) is common both Alzheimer's disease (AD) and vascular dementia (VaD).The aim of this study to investigate the different patterns regional (rCBF) change cerebrovascular reactivity (CVR) these two types dementia. Mean velocity (MFV) middle artery rCBF were measured by Transcranial Doppler ultrasound (TCD) arterial spin-labeling (ASL) magnetic resonance, separately. CVR was evaluated MFV or response 5% CO2 inhalation. The ASL results showed...
To investigate whether cortical superficial siderosis (cSS) is associated with increased risk of future first-ever symptomatic lobar intracerebral hemorrhage (ICH) in patients cerebral amyloid angiopathy (CAA) presenting neurologic symptoms and without ICH.Consecutive meeting modified Boston criteria for probable CAA the absence ICH from a single-center cohort were analyzed. cSS other small vessel disease MRI markers assessed according to recent consensus recommendations. Patients followed...
Background: Cerebral amyloid angiopathy (CAA) is increasingly recognized as a cause of cognitive impairment in the elderly, but profile patients with disease has not been well characterized. Objective: To characterize neuropsychological CAA without demen tia and to determine association between performance different domains neuroimaging lesions characteristic CAA. Methods: Fifty-eight non-demented were compared 138 cognitively normal subjects using standard test battery. Total brain volume...
To characterize the temporal and spatial pattern of cerebral microbleeds (CMBs) after cranial irradiation in patients with medulloblastoma.
Cerebral amyloid angiopathy (CAA) is a common cause of cognitive impairment in older individuals. This study aimed to investigate predictors dementia CAA patients without intracerebral hemorrhage (ICH). A total 158 non-demented from the Stroke Service or Memory Clinic who met modified Boston Criteria for probable were included. At baseline, neuroimaging markers, including lobar microbleeds (cerebral (CMBs)), white matter hyperintensities (WMH), cortical superficial siderosis (cSS), magnetic...
Background and Purpose— Spontaneous cerebellar intracerebral hemorrhage (ICH) has been reported to be mainly associated with vascular changes secondary hypertension. However, a subgroup of ICH seems related amyloid deposition (cerebral angiopathy). We sought determine whether location hematoma in the cerebellum (deep superficial regions) was suggestive particular hemorrhage-prone small-vessel disease pathology angiopathy or hypertensive vasculopathy). Methods— Consecutive patients from...
To address the pathophysiologic nature of small diffusion-weighted imaging (DWI) lesions in patients with cerebral amyloid angiopathy (CAA) who underwent serial MRI. Specifically, we tested (1) whether DWI occurred preferentially individuals prior lesions, (2) cross-sectional association chronic cortical microinfarcts (CMIs), and (3) evolution over time.
Background and Purpose- Hematoma location within the cerebellum may help identify dominant small vessel disease type (cerebral amyloid angiopathy [CAA] versus nonamyloid disease). However, it is unknown whether this holds true for cerebral microbleeds (CMBs) cerebellum. We tested hypothesis that cerebellar CMBs restricted to cortex vermis (defined as superficial regions) are associated with clinically diagnosed pathology-verified CAA. Methods- Three hundred seven consecutive spontaneous...
<h3>BACKGROUND AND PURPOSE:</h3> Whole-brain network connectivity has been shown to be a useful biomarker of cerebral amyloid angiopathy and related cognitive impairment. We evaluated an automated DTI-based method, peak width skeletonized mean diffusivity, in angiopathy, together with its association conventional MRI markers functions. <h3>MATERIALS METHODS:</h3> included 24 subjects (mean age, 74.7 [SD, 6.0] years) probable mild impairment 62 patients MCI not attributable (non-cerebral...
Objective This study aimed to assess the feasibility of deep learning in generating T2 weighted (T2W) images from diffusion-weighted imaging b0 images. Materials and methods retrospective included 53 patients who underwent head magnetic resonance between September 1 4, 2023. Each image was matched with a corresponding T2-weighted image. A total 954 pairs were divided into training set 763 test 191 pairs. The Hybrid-Fusion Network (Hi-Net) pix2pix algorithms employed synthesize T2W (sT2W)...
The triglyceride-glucose (TyG) index, a reliable surrogate marker of insulin resistance, has been shown as an independent risk factor for stroke. Still, the interaction between metabolic syndrome (MetS) and TyG index in determining stroke remains to be clarified, which may help optimize prevention strategies. This study aims explore whether influences association A total 7770 middle-aged older participants free at baseline were enrolled from China Health Retirement Longitudinal Study. was...
Background and Purpose— We recently showed that cerebral amyloid angiopathy (CAA) is associated with functionally relevant brain network impairments, in particular affecting posterior white matter connections. Here we examined how these impairments progress over time. Methods— Thirty-three patients probable CAA underwent multimodal magnetic resonance imaging at 2 time points (mean follow-up time: 1.3±0.4 years). Brain networks of the hemisphere free intracerebral hemorrhages were...
Hypoxia inducible factor 1α (HIF-1α), a pivotal regulator of gene expression in response to hypoxia and ischemia, is now considered regulate both pro-survival pro-death responses depending on the duration severity stress. We previously showed that chronic global cerebral hypoperfusion (CCH) triggered long-lasting accumulation HIF-1α protein hippocampus rats. However, role stabilized CCH obscure. Here, we knock down endogenous determine whether how affects disease processes phenotypes CCH....
Cerebral amyloid angiopathy (CAA) is a common age-related small vessel disease (SVD). Patients without intracerebral hemorrhage (ICH) typically present with transient focal neurologic episodes (TFNEs) or cognitive symptoms. We sought to determine if SVD lesion burden differed between patients CAA first presenting TFNEs vs symptoms.A total of 647 either stroke department (n = 205) an outpatient memory clinic 442) were screened for eligibility. meeting modified Boston criteria probable...
Background and Purpose- We aimed to explore the association between presence of cerebral cortical microinfarcts (CMIs) on magnetic resonance imaging other small-vessel disease neuroimaging biomarkers in amyloid angiopathy (CAA) analyze role CMIs individual cognitive domains dementia conversion. Methods- Participants were recruited from an ongoing longitudinal research cohort eligible CAA patients March 2006 October 2016. A total 102 cases included analysis that assessed relationship markers....
Genetic variants at KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 have been associated with type 2 diabetes mellitus (T2DM), but the results are contradictory in Chinese populations. The aim of present study was to investigate association these four SNPs T2DM a large population Han Henan province, China. Seven-hundred-thirty-six patients (cases) Seven-hundred-sixty-eight healthy glucose-tolerant controls were genotyped for rs10830963. genetic genes analyzed using...
Background and Purpose- We investigated cortical superficial siderosis (cSS) progression its clinical relevance for incident lobar intracerebral hemorrhage (ICH) risk, in probable cerebral amyloid angiopathy presenting with neurological symptoms without ICH at baseline. Methods- Consecutive patients meeting modified Boston criteria from a single-center cohort who underwent magnetic resonance imaging (MRI) baseline during follow-up were analyzed. cSS was assessed by comparison of the images....