A5026206391- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and genetic disorders
- Cardiovascular Health and Disease Prevention
- Radiomics and Machine Learning in Medical Imaging
- Amyloidosis: Diagnosis, Treatment, Outcomes
- CNS Lymphoma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- IgG4-Related and Inflammatory Diseases
- Neurological Disorders and Treatments
- Neurosurgical Procedures and Complications
- Neurological and metabolic disorders
- Machine Learning in Healthcare
- Cardiac Imaging and Diagnostics
- Head and Neck Surgical Oncology
- Autoimmune and Inflammatory Disorders
- Sarcoidosis and Beryllium Toxicity Research
Universidade de São Paulo
2019-2024
Massachusetts General Hospital
2020-2024
Harvard University
2020-2024
King Chulalongkorn Memorial Hospital
2023
Thai Red Cross Society
2023
Chulalongkorn University
2023
University of Geneva
2023
Clinics Hospital of Ribeirão Preto
2019-2023
University Hospital of Geneva
2023
Rush University Medical Center
2023
Objective Determining the underlying causes of intracerebral hemorrhage (ICH) is major importance, because risk factors, prognosis, and management differ by ICH subtype. We developed a new causal CLASsification system for Subtypes, termed CLAS‐ICH, based on recent advances in neuroimaging. Methods CLAS‐ICH defines 5 subtypes: arteriolosclerosis, cerebral amyloid angiopathy, mixed small vessel disease (SVD), other rare forms SVD (genetic others), secondary (macrovascular causes, tumor,...
<h3>BACKGROUND AND PURPOSE:</h3> Whole-brain network connectivity has been shown to be a useful biomarker of cerebral amyloid angiopathy and related cognitive impairment. We evaluated an automated DTI-based method, peak width skeletonized mean diffusivity, in angiopathy, together with its association conventional MRI markers functions. <h3>MATERIALS METHODS:</h3> included 24 subjects (mean age, 74.7 [SD, 6.0] years) probable mild impairment 62 patients MCI not attributable (non-cerebral...
Abstract Background To promote the development of effective therapies, there is an important need to characterize full spectrum neuropathological changes associated with Alzheimer’s disease. In line this need, study examined white matter abnormalities in individuals early-onset autosomal dominant disease, relation age and symptom severity. Methods This a cross-sectional analysis data collected members large kindred PSEN1 E280A mutation. Participants were recruited between September 2011 July...
Abstract Background and Purpose Ischemic diffusion‐weighted imaging‐fluid‐attenuated inversion recovery (DWI‐FLAIR) mismatch may be useful in guiding acute stroke treatment decisions given its relationship to onset time parenchymal viability; however, it relies on subjective grading. Radiomics is an emerging image quantification methodology that objectively represent continuous characteristics. We propose a novel radiomics approach characterize DWI‐FLAIR mismatch. Methods lesions were...
The Boston criteria are a set of clinical and neuroimaging features that enable accurate diagnosis cerebral amyloid angiopathy (CAA) without invasive methods such as brain biopsies or autopsy. last updates to the criteria, named version 2.0, were recently released incorporated new nonhemorrhagic MRI features. These have been validated in symptomatic samples, with improved diagnostic yield. We out investigate accuracy v2.0 for CAA community-based sample.
<b><i>Background:</i></b> Basilar artery occlusion (BAO) is a rare stroke subtype with high mortality rates. Best BAO reperfusion strategy still controversial. <b><i>Objective:</i></b> We aim to describe outcomes of patients submitted mechanical thrombectomy (MT) in comprehensive center Brazil and analyze which previous published computed tomography angiography (CTA) collateral score better predict functional outcomes....
Relying on tau-PET imaging, this cross-sectional study explored whether memory impairment is linked to the presence of concomitant tau pathology in individuals with cerebral amyloid angiopathy (CAA).Forty-six patients probable CAA underwent a neuropsychological examination and an MRI for quantification structural markers small vessel disease. A subset these participants also completed [11C]-Pittsburgh compound B (n = 39) [18F]-flortaucipir 40) PET vivo estimation burden, respectively....
Peak width of skeletonized mean diffusivity (PSMD) is a promising diffusion tensor imaging (DTI) marker that shows consistent and strong cognitive associations in the context different cerebral small vessel diseases (cSVD).Investigate whether PSMD (1) higher patients with Cerebral Amyloid Angiopathy (CAA) than those arteriolosclerosis; (2) can capture anteroposterior distribution CAA-related abnormalities; (3) similar neuroimaging comparison to other classical DTI markers, such as average...
Accumulating evidence suggests that gray matter atrophy, often considered a marker of Alzheimer disease (AD), can also result from cerebral small vessel (CSVD). Cerebral amyloid angiopathy (CAA) is form sporadic CSVD, diagnosed through neuroimaging criteria, co-occurs with AD pathology and leads to cognitive impairment. We sought identify the role hippocampal integrity in development impairment cohort patients possible probable CAA.
Abstract The impact of vascular lesions on cognition is location dependent. Here, we assessed the contribution small vessel disease in corpus callosum to cognitive impairment cerebral amyloid angiopathy, as a model for disease. Sixty-five patients with probable angiopathy underwent 3T magnetic resonance imaging, including diffusion tensor imaging scan, and neuropsychological testing. Microstructural white-matter integrity was quantified by fractional anisotropy mean diffusivity. Z-scores...
Background Cerebral Amyloid Angiopathy (CAA) is a cerebral small vessel disease that can lead to microstructural disruption of white matter (WM), which be measured by the Peak Width Skeletonized Mean Diffusivity (PSMD). We hypothesized PSMD measures would increased in patients with CAA compared healthy controls (HC), and associated lower cognitive scores CAA. Methods Eighty-one probable without impairment who were diagnosed Boston criteria 23 HCs included. All subjects underwent an advanced...
A definite diagnosis of cerebral amyloid angiopathy (CAA), characterized by the accumulation β in walls small vessels, can only be obtained through pathological examination. probable CAA during life relies on presence hemorrhagic markers, including lobar microbleeds (CMBs). The aim this project was to study histopathological correlates CMBs false-positive cases.
Primary Sjögren's syndrome (pSS) is an important cause of renal tubular dysfunction in adults, mainly due to acquired type 1 distal acidosis (RTA 1) and concentration defects (CD). This cross-sectional study evaluated function patients with pSS, by detecting proximal injury (through measurements urinary β2 microglobulin albumin), RTA acidification protocol using furosemide fludrocortisone), CD water deprivation test, WDT). A total 25 pSS were despite a preserved (eGFR 92.5 ± 26.3 mL/min/1.73...
<h3>Background and Objective</h3> To analyze the prevalence associated clinical characteristics of apathy in sporadic cerebral amyloid angiopathy investigate whether was with disease burden disconnections key structures reward circuit through a structural functional multimodal neuroimaging approach. <h3>Methods</h3> Thirty-seven participants probable without symptomatic intracranial hemorrhage or dementia (mean age, 73.3 ± 7.2 years, % male = 59.5%) underwent detailed neuropsychological...
CBF measured with Arterial Spin Labeling (ASL) obtained by Magnetic Resonance Imaging (MRI) may become an important biomarker showing changes in early stages of AD, such as the prodromal stage Mild Cognitive Impairment (MCI).Verify correlation between atrophy and patients MCI mild phase ADD, to demonstrate whether can be considered vascular biomarkers diagnosis DA continuum.11 healthy volunteers, 16 15 ADD were evaluated. Images brain acquired, including (ASL).When comparing control, a...
ABSTRACT Introduction Long-term systolic blood pressure variability (BPV) has been proposed as a novel risk factor for dementia, but the underlying mechanisms are largely unknown. We aimed to investigate association between long-term (BPV), brain injury, and cognitive decline in patients with mild symptoms cerebral amyloid angiopathy (CAA), well-characterized small-vessel disease that causes older adults. Methods Using prospective memory clinic cohort, we enrolled 102 participants, of whom...
White matter hyperintensities (WMHs) are frequently observed on magnetic resonance imaging (MRI) in patients with cerebral amyloid angiopathy (CAA). The neuropathological substrates that underlie WMHs CAA unclear, and it remains largely unexplored whether the different WMH distribution patterns associated (posterior confluent subcortical multispot) reflect alternative pathophysiological mechanisms.
Purpose: To describe the occurrence of multiple trigeminal nerves (TGNs) enlargement in patients with orbital IgG4-related disease. Methods: Retrospective review MRI findings and medical records 6 (10 orbits) disease more than 1 TGN. Orbital biopsies were performed all cases revealing typical lymphoplasmacytic infiltrate significant plasma cell positivity for IgG4 (IgG4+/IgG ratio ≥ 40%). Three experienced neuroradiologists reviewed sequences using a digital imaging viewer system (Horos,...
<h3>Objective</h3> To investigate whether acute convexity subarachnoid hemorrhage (cSAH) detected on CT in lobar intracerebral (ICH) related to cerebral amyloid angiopathy (CAA) is associated with recurrent ICH. <h3>Methods</h3> We analyzed data from a prospective cohort of consecutive ICH survivors fulfilling the Boston criteria for possible or probable CAA who had both brain and MRI at index Presence cSAH was assessed blinded data. Cortical superficial siderosis (cSS), microbleeds, white...