A5026447128- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Alzheimer's disease research and treatments
- MRI in cancer diagnosis
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Neurological Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Neurological disorders and treatments
- Dementia and Cognitive Impairment Research
- Cerebrovascular and genetic disorders
- Advanced Neuroimaging Techniques and Applications
- Myasthenia Gravis and Thymoma
- Cerebrospinal fluid and hydrocephalus
- Parkinson's Disease Mechanisms and Treatments
- Brain Tumor Detection and Classification
- Genetic and Kidney Cyst Diseases
- Ophthalmology and Eye Disorders
- Genetic Neurodegenerative Diseases
- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Mitochondrial Function and Pathology
Massachusetts General Hospital
2020-2025
Harvard University
2020-2025
Beth Israel Deaconess Medical Center
2023
Université de Tours
2023
Athinoula A. Martinos Center for Biomedical Imaging
2021
Inserm
2021
Université de Lille
2021
Centre Hospitalier Universitaire de Lille
2021
Bezmiâlem Vakıf Üniversitesi
2016-2020
Aga Khan Foundation
2020
Patent foramen ovale (PFO) is frequently identified in young patients with ischemic stroke. Randomized controlled trials provide robust evidence supporting PFO closure selected cryptogenic stroke; however, several questions remain unanswered. This report summarizes current knowledge on the epidemiology of PFO-associated stroke, role as a cause and anatomic high-risk features. We also comment breakthrough developments patient selection algorithms for relation to stroke causal likelihood risk...
This study aimed to evaluate motor and non-motor symptoms in idiopathic Parkinson's disease (IPD) patients determine the self-reported influence of all existing on their quality life (QoL).The sociodemographic clinical characteristics, medical treatments, Modified Hoehn Yahr (mH&Y) scores IPD without cognitive impairment were recorded. A survey questioning different was administered patients. The asked rate by number from greatest least QoL. Subjects divided into two groups: those suffering...
Introduction: The recent update (version 2.0) to the Boston criteria for cerebral amyloid angiopathy (CAA) adds two additional neuroimaging markers increase sensitivity of CAA detection: multispot white matter hyperintensity (WMH) pattern and severe centrum semiovale enlarged perivascular spaces (CSO EPVS). While presence these novel non-hemorrhagic markers, together with well-established hemorrhagic such as lobar microbleeds (CMBs) cortical superficial siderosis (cSS), increases likelihood...
Introduction: Atrial fibrillation (AF) has been linked to cognitive impairment and dementia (CID) even among patients without clinically obvious stroke, but the mechanism is not established. In this study, we aim clarify relationship between burden of AF CID in a cohort any history stroke. We hypothesized that higher would be associated with CID, possibly through more pronounced cerebral hypoperfusion covert infarcts. Methods: included 843 clinical stroke or neurodegenerative disease, who...
Objective: We sought to investigate the consequences of alcohol intake on intracerebral hemorrhage (ICH) and cerebral small vessel disease (cSVD) in patients with spontaneous ICH. Methods: compared markers cSVD [Figure 1], features ICH, outcomes among consecutive ICH different use strata admitted a tertiary care center between 2003-2019. Alcohol was categorized as none/mild (<5 drinks/week), moderate/severe (5 drinks/week-5 drinks/day), heavy (>5 drinks/day). performed descriptive...
Introduction: The brain's glymphatic system is crucial for clearing metabolic waste and maintaining balanced fluid circulation within the brain. Enlarged perivascular spaces in basal ganglia (EPVS-BG) are markers of hypertensive cerebral small vessel disease (HTN-cSVD) due to dysfunction. Atrial fibrillation (AF) has been proposed increase wall shear stress blood pressure lenticulostriate arteries (LSA), both potentially contributing dysfunction cSVD development. We hypothesized that a...
We postulated that cerebral amyloid angiopathy (CAA) is associated with white matter atrophy (WMA) and WMA can be related to cognitive changes in CAA.White volume expressed as percent of intracranial (pWMV) prospectively enrolled patients without dementia diagnosed probable CAA was compared age-matched healthy controls (HC) Alzheimer disease (AD). Cognitive scores were also sought understand the potential effects on function.Patients (n = 72) had significantly lower pWMV (27.97% ± 2.63) when...
Stroke is a leading cause of death and disability in the United States worldwide, necessitating comprehensive efforts to optimize stroke risk factor management. Health disparities incidence, prevalence, management persist among various race/ethnic, geographic, socioeconomic populations negatively impact outcomes. This review highlights existing literature guidelines for management, emphasizing health certain populations. Moreover, factors special groups, including young, very elderly,...
Background: In this study, we assessed 75 patients with myasthenia gravis (MG) for coexistent autoimmune diseases (ADs) and the characteristic autoantibodies that are associated most relevant forms of ADs.Methods: The demographic clinical characteristics were recorded. all patients, thyroid function tests, autoantibodies, other studied. diagnosis disease (AITD) was made based on features, physical examination, laboratory findings. diagnoses rheumatoid arthritis (RA) systemic lupus...
Abstract The impact of vascular lesions on cognition is location dependent. Here, we assessed the contribution small vessel disease in corpus callosum to cognitive impairment cerebral amyloid angiopathy, as a model for disease. Sixty-five patients with probable angiopathy underwent 3T magnetic resonance imaging, including diffusion tensor imaging scan, and neuropsychological testing. Microstructural white-matter integrity was quantified by fractional anisotropy mean diffusivity. Z-scores...
Background Cerebral Amyloid Angiopathy (CAA) is a cerebral small vessel disease that can lead to microstructural disruption of white matter (WM), which be measured by the Peak Width Skeletonized Mean Diffusivity (PSMD). We hypothesized PSMD measures would increased in patients with CAA compared healthy controls (HC), and associated lower cognitive scores CAA. Methods Eighty-one probable without impairment who were diagnosed Boston criteria 23 HCs included. All subjects underwent an advanced...
<h3>Objective</h3> To analyze the relationship of lacunes with cortical cerebral microinfarcts (CMIs), to assess their association vascular dysfunction, and evaluate effect on risk incident intracerebral hemorrhage (ICH) in amyloid angiopathy (CAA). <h3>Methods</h3> The count topography (deep/lobar), CMIs, white matter hyperintensity (WMH) volume were retrospectively analyzed a prospectively enrolled CAA cohort that underwent high-resolution research MRIs. CMIs other CAA-related markers...
Hypertensive cerebral small vessel disease (HTN-cSVD) is the predominant microangiopathy in patients with a combination of lobar and deep microbleeds (CMBs) intracerebral hemorrhage (mixed ICH). We tested hypothesis that amyloid angiopathy (CAA) also contributing mixed ICH cortical superficial siderosis (cSS), marker strongly associated CAA.
We postulated that vascular dysfunction mediates the relationship between amyloid load and white matter hyperintensities (WMH) in cerebral angiopathy (CAA). Thirty-eight cognitively healthy patients with CAA (mean age 70 ± 7.1) were evaluated. WMH was quantified expressed as percent of total intracranial volume (pWMH) using structural MRI. Mean global cortical Distribution Volume Ratio representing Pittsburgh Compound B (PiB) uptake (PiB-DVR) calculated from PET scans. Time-to-peak [TTP]...
Background and objectives Although left atrial appendage closure (LAAC) is performed in patients with non-valvular fibrillation (NVAF) at increased risk of intracranial haemorrhage (ICH), outcome data are scarce. We assessed the detailed neurological indications for LAAC outcomes after high ICH patients. Methods Study population included consecutive NVAF who underwent a single hospital network between January 2015 October 2021 because prior or presence imaging markers on brain MRI (cerebral...
Motivation: Neuronal activity induces vasodilation in local arterioles that propagates to upstream large arteries, but the furthest detectable arterial dilation from site of neuronal remains unknown. Goal(s): Detecting blood velocity responses at far branches Posterior Cerebral Artery induced by a visual stimulus. Approach: In this study, functional phase-contrast MRA technique was combined with commonly used block-design stimulation paradigm detect responses. Results: About 10&ndash;20%...