Frank A. Wollenweber
A5077921096- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Cerebrovascular and genetic disorders
- Prostate Cancer Treatment and Research
- Intracranial Aneurysms: Treatment and Complications
- Neurological disorders and treatments
- Neurosurgical Procedures and Complications
- Atrial Fibrillation Management and Outcomes
- Medical Imaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Neurological Disorders and Treatments
- Vestibular and auditory disorders
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Health and Disease Prevention
- Moyamoya disease diagnosis and treatment
- Radiopharmaceutical Chemistry and Applications
- Neurological Disease Mechanisms and Treatments
- Clinical practice guidelines implementation
- Cerebral Venous Sinus Thrombosis
Helios Dr. Horst Schmidt Kliniken Wiesbaden
2020-2025
Ludwig-Maximilians-Universität München
2015-2024
Landscape Research Group
2023
University Hospital Leipzig
2023
Authorised Association Consortium
2023
LMU Klinikum
2015-2022
St. Josefs Hospital
2021-2022
Helios Klinikum Erfurt
2022
University Medical Center Freiburg
2021
Klinik und Poliklinik für Neurologie
2017-2020
Background and Purpose— Endovascular treatment for large vessel occlusion in ischemic stroke has proven to be effective clinical trials. We aimed provide real-world estimates of endovascular reperfusion rates functional outcome on a countrywide scale. Methods— Two thousand seven hundred ninety-four patients with were included into an investigator-initiated, industry-independent, prospective registry 25 sites Germany between June 2015 April 2018. The primary was the score modified Rankin...
To study remote effects distant from acute ischemic infarcts by measuring longitudinal changes of cortical thickness in connected brain regions as well microstructural integrity connecting fiber tracts.Thirty-two patients (mean age 71 years) underwent a standardized protocol including multimodal MRI and clinical assessment both at stroke onset 6 months after the event. Cortex to was identified probabilistic diffusion tensor tractography starting lesion. Changes were measured using stream...
<h3>Objective</h3> To explore the utility of serum neurofilament light chain (NfL) as a biomarker for primary and secondary neuroaxonal injury after ischemic stroke (IS) study its value prediction clinical outcome. <h3>Methods</h3> We used an ultrasensitive single-molecule array assay to measure NfL levels in healthy controls (n = 30) 2 independent cohorts patients with IS: (1) serial sampling at hospital arrival 196), days 2, 3, 7 89), up 6 months post stroke; (2) standardized MRI baseline...
Background: Andexanet alfa is a modified recombinant inactive factor Xa (FXa) designed to reverse FXa inhibitors. ANNEXA-4 (Andexanet Alfa, Novel Antidote the Anticoagulation Effects of Factor Inhibitors) was multicenter, prospective, phase-3b/4, single-group cohort study that evaluated andexanet in patients with acute major bleeding. The results final analyses are presented. Methods: Patients bleeding within 18 hours inhibitor administration were enrolled. Co-primary end points anti-FXa...
<h3>Objective</h3>To evaluate whether enlarged substantia nigra hyperechogenicity (SN+) is associated with an increased risk for Parkinson disease (PD) in a healthy elderly population.<h3>Design</h3>Longitudinal 3-center observational study 37 months of prospective follow-up.<h3>Setting</h3>Individuals 50 years or older without evidence PD any other neurodegenerative disease.<h3>Participants</h3>Of 1847 participants who underwent full medical history, neurological assessment, and...
<h3>Objective</h3> To examine whether the Montreal Cognitive Assessment (MoCA) administered within 7 days after stroke predicts long-term cognitive impairment, functional and mortality. <h3>Methods</h3> MoCA was to 274 patients from 2 prospective hospital-based cohort studies in Germany (n = 125) France 149). outcomes were assessed at 6, 12, 36 months by comprehensive neuropsychological testing, Clinical Dementia Rating (CDR) scale, modified Rankin Scale (mRS), Instrumental Activities of...
Background and Purpose— Assessment of cognitive status poststroke is recommended by guidelines but follow-up can often not be done in person. The Telephone Interview Cognitive Status (TICS) the Montreal (T-MoCA) are considered useful screening instruments. Yet, evidence to define optimal cut-offs for mild impairment (MCI) after stroke limited. Methods— We studied 105 patients enrolled prospective DEDEMAS study (Determinants Dementia After Stroke; NCT01334749). Follow-up visits at 6, 12, 36,...
The underlying etiology of ischemic stroke remains unknown in up to 30% patients.This study explored the causal role complicated (American Heart Association-lesion type VI) nonstenosing carotid artery plaques (CAPs) cryptogenic (CS).CAPIAS (Carotid Plaque Imaging Acute Stroke) is an observational multicenter that prospectively recruited patients aged older than 49 years with acute was restricted territory a single on brain magnetic resonance imaging (MRI) and unilateral or bilateral CAP (≥2...
Background Endovascular treatment has become standard of care for the acute ischemic stroke with large vessel occlusion. However, patients treated in clinical practice differ from selected populations randomized trials. Aims The German Stroke Registry Treatment (GSR-ET) aims at a systematic evaluation outcome, safety, and process parameters endovascular Germany. Methods GSR-ET is an academic, independent, prospective, multicenter, observational registry study. Participating centers all over...
Complicated nonstenosing carotid artery plaques (CAPs) are an under-recognized cause of stroke.The purpose this study was to determine whether complicated CAP ipsilateral acute ischemic anterior circulation stroke (icCAP) associated with recurrent or transient attack (TIA).The CAPIAS (Carotid Plaque Imaging in Acute Stroke) multicenter prospectively recruited patients restricted the territory a single artery. (AHA-lesion type VI) were defined by multisequence, contrast-enhanced magnetic...
Abstract Introduction It remains unknown whether the global small vessel disease (SVD) burden predicts post‐stroke outcomes. Methods In a prospective multicenter study of 666 ischemic and hemorrhagic stroke patients, we quantified magnetic resonance imaging (MRI)–based SVD markers (lacunes, white matter hyperintensities, microbleeds, perivascular spaces) explored associations with 6‐ 12‐month cognitive (battery 15 neuropsychological tests) functional (modified Rankin scale) Results A score...
The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants vascular contributions cognitive disorders help improve diagnosis treatment (VCD).
Background Patients aged ≥90 were excluded or under‐represented in past thrombectomy trials; thus, uncertainty remains whether treatment benefits can be expected regardless of age. This study investigates outcome and safety nonagenarians to improve decision making a real‐world setting. Methods Results All currently available data patients enrolled the GSR‐ET (German Stroke Registry–Endovascular Treatment) combined with smaller cohort from 3 tertiary stroke centers. Baseline characteristics,...
This study evaluates the benefit of endovascular treatment (EVT) for patients with extensive baseline stroke compared best medical treatment.This retrospective, multicenter compares EVT and computed tomography (CT)–based selection infarcts (Alberta Stroke Program Early CT Score ≤5) attributed to anterior circulation stroke. Patients were selected from German Registry 3 tertiary centers. Primary functional end points rates good (modified Rankin Scale score ≤3) very poor outcome ≥5) at 90...
Endovascular therapy is the standard of care in treatment acute ischemic stroke due to large-vessel occlusion. A direct association between number device passes and occurrence symptomatic intracranial hemorrhage (SICH) has been suggested. This study represents an in-depth investigation hypothesis that >3 retrieval attempts associated with increased rate SICH a large multicenter patient cohort. Two thousand six hundred eleven patients from prospective German Stroke Registry were analyzed....
Rationale The Boston criteria are used worldwide for the in vivo diagnosis of cerebral amyloid angiopathy and basis clinical decision-making research field. Given substantial advances angiopathy's aspects MRI biomarkers, we designed a multicenter study within International Association aimed at further validating diagnostic accuracy potentially improving updating them. Aim We aim to derive validate an updated “version 2.0” across spectrum angiopathy-related presentations biomarkers. Sample...
Background and Purpose- Stroke etiology drives thrombus composition. We thus hypothesized that endovascular treatment shows different efficacy in cardioembolic versus noncardioembolic large-vessel occlusions (LVOs). Methods- Procedural characteristics, grade of reperfusion, functional outcome at discharge 90 days were compared between patients with LVO from the GSR-ET (German Registry-Endovascular Treatment; n=2589). To determine associations outcome, adjusted odds ratios 95% CIs calculated...
Abstract Introduction The Meta VCI Map consortium performs meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain coverage and support comprehensive mapping studies. Methods Cohorts with available imaging white matter hyperintensities or infarcts testing were invited. We performed a pilot study test the feasibility multicenter processing analysis...
Subclinical hyperthyroidism is associated with adverse cardiovascular events, including stroke and atrial fibrillation. However, its impact on functional outcome after remains unexplored.A total of 165 consecutively recruited patients admitted for ischemic were included in this observational prospective study. Blood samples taken the morning within 3 days symptom onset, divided into following groups: subclinical (0.1< thyroid-stimulating hormone ≤ 0.44 μU/mL), hypothyroidism (2.5 <20...
Mutations in NOTCH3 cause cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common monogenic of stroke vascular dementia. Misfolding aggregation proteins triggered by cysteine-affecting mutations are considered to be key disease mechanisms. However, significance cysteine-sparing is still debated.We studied a family inherited small vessel standardized medical history, clinical examination, MRI, ultrastructural analysis skin...