A5015592473- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Retinal Imaging and Analysis
- Cerebrovascular and genetic disorders
- Neurological Disorders and Treatments
- Stroke Rehabilitation and Recovery
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- Cerebral Venous Sinus Thrombosis
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- MRI in cancer diagnosis
- Retinal and Optic Conditions
- Traumatic Brain Injury and Neurovascular Disturbances
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Fetal and Pediatric Neurological Disorders
- Palliative Care and End-of-Life Issues
- Patient-Provider Communication in Healthcare
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
University of Edinburgh
2016-2025
UK Dementia Research Institute
2017-2025
Capital Medical University
2020-2024
National Clinical Research
2024
Ruijin Hospital
2024
Edinburgh Royal Infirmary
2013-2024
Sichuan University
2024
University of Hong Kong
2024
National Health Service
2022
Maastricht University Medical Centre
2014-2022
In this cross-sectional study, we tested the construct validity of a "total SVD score," which combines individual MRI features small-vessel disease (SVD) in one measure, by testing associations with vascular risk factors and stroke subtype.We analyzed data from patients lacunar or nondisabling cortical 2 prospective studies. Brain was rated for presence lacunes, white matter hyperintensities, cerebral microbleeds, perivascular spaces independently. The each feature summed an ordinal "SVD...
Enlarged perivascular spaces in the brain are common but generally overlooked and of uncertain pathophysiology. They may reflect underlying cerebral small vessel disease. We determined whether enlarged were associated with lacunar stroke subtype white matter hyperintensities, markers established disease.We prospectively recruited patients acute ischemic or cortical stroke. Age-matched nonstroke control subjects also recruited. rated basal ganglia centrum semiovale 0 to 4 (0=none, 4=>40) on...
Abstract Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging–Alzheimer's Association describes biomarker‐based pathologic definition of focused amyloid, tau, neuronal injury. In response this article, here we first discussed that dysfunction is an important early event in...
If the diagnostic and prognostic significance of brain microbleeds (BMBs) are to be investigated used for these purposes in clinical practice, observer variation BMB assessment must minimized.
Abstract Objective Lacunar stroke is common (25% of ischemic strokes) and mostly because an intrinsic cerebral microvascular disease unknown cause. Although considered primarily to be process, the vessel tissue damage could also explained by dysfunctional endothelium or blood–brain barrier (BBB) leak, not just ischemia. We tested for subtle generalized BBB leakiness in patients with lacunar control cortical stroke. Methods recruited mild assessed leak gray matter, white cerebrospinal fluid,...
Enlarged perivascular spaces (also known as Virchow-Robin spaces) on T2-weighted brain magnetic resonance imaging are common, but their etiology, and specificity to small vessel opposed general cerebrovascular disease or ageing, is unclear. We tested the association between enlarged ischemic stroke subtype, other markers of disease, common vascular risk factors.We prospectively recruited patients with acute stroke, diagnosed subtyped by a physician using clinical features imaging. A...
To determine the magnitude of potentially causal relationships among vascular risk factors (VRFs), large-artery atheromatous disease (LAD), and cerebral white matter hyperintensities (WMH) in 2 prospective cohorts.
BackgroundAntiplatelet therapy reduces the risk of major vascular events for people with occlusive disease, although it might increase intracranial haemorrhage. Patients surviving commonest subtype haemorrhage, intracerebral are at both haemorrhagic and events, but whether antiplatelet can be used safely is unclear. We aimed to estimate relative absolute effects on recurrent haemorrhage this exceed any reduction events.MethodsThe REstart or STop Antithrombotics Randomised Trial (RESTART) was...
‘Covert’ cerebral small vessel disease (ccSVD) is common on neuroimaging in persons without overt neurological manifestations, and increases the risk of future stroke, cognitive impairment, dependency, death. These European Stroke Organisation (ESO) guidelines provide evidence-based recommendations to assist with clinical decisions about management ccSVD, specifically white matter hyperintensities lacunes, prevent adverse outcomes. The were developed according ESO standard operating...
Importance Cerebral small vessel disease (cSVD) is a common cause of stroke (lacunar stroke), the most vascular cognitive impairment, and impairs mobility mood but has no specific treatment. Objective To test feasibility, drug tolerability, safety, effects 1-year isosorbide mononitrate (ISMN) cilostazol treatment on vascular, functional, outcomes in patients with lacunar stroke. Design, Setting, Participants The Lacunar Intervention Trial-2 (LACI-2) was an investigator-initiated, open-label,...
A quarter of ischaemic strokes are lacunar subtype, typically neurologically mild, usually resulting from intrinsic cerebral small vessel pathology, with risk factor profiles and outcome rates differing other stroke subtypes. This European Stroke Organisation (ESO) guideline provides evidence-based recommendations to assist clinical decisions about management prevent adverse outcomes. The was developed according ESO standard operating procedures Grading Recommendations, Assessment,...
<b>Objectives:</b> Lacunar strokes account for 25% of all ischemic and may represent the cerebral manifestation a systemic small vessel vasculopathy unknown etiology. Altered retinal fractal dimensions act as surrogate marker diseased vessels. We used cross-sectional study to investigate properties vessels in lacunar stroke. <b>Methods:</b> recruited patients presenting with stroke minor cortical controls. All were examined by expert had MRI at presentation. Digital photographs taken both...
Increased blood-brain barrier (BBB) permeability occurs in cerebral small vessel disease. It is not known if BBB changes predate progression of disease.We followed-up patients with nondisabling lacunar or cortical stroke and magnetic resonance imaging after their original stroke. Approximately 3 years later, we assessed functional outcome (Oxford Handicap Score, poor defined as 3-6), recurrent neurological events, white matter hyperintensity (WMH) on imaging.Among 70 mean age 68 (SD ± 11)...
The characteristics of intracerebral hemorrhage (ICH) may vary by ICH location because differences in the distribution underlying cerebral small vessel diseases. Therefore, we investigated incidence, characteristics, and outcome lobar nonlobar ICH.In a population-based, prospective inception cohort study ICH, used multiple overlapping sources case ascertainment follow-up to identify validate diagnoses 2010 2011 an adult population 695 335.There were 128 participants with first-ever primary...
<h3>Objective</h3> To investigate cerebrovascular reactivity (CVR), blood flow, vascular and CSF pulsatility, their independent relationship with cerebral small vessel disease (SVD) features in patients minor ischemic stroke MRI evidence of SVD. <h3>Methods</h3> We recruited assessed CVR using oxygen level–dependent during a hypercapnic challenge, flow (CBF), pulsatility phase-contrast MRI, structural magnetic resonance brain imaging to quantify white matter hyperintensities (WMHs)...
Abstract Gait and balance impairment is highly prevalent in older people. We aimed to assess whether how single markers of small vessel disease (SVD) or a combination thereof explain gait function the elderly. analysed 678 community-dwelling healthy subjects from Lothian Birth Cohort 1936 at age 71–74 years who had undergone comprehensive risk factor assessment, assessment as well brain MRI. investigated impact individual SVD (white matter hyperintensity – WMH, microbleeds, lacunes, enlarged...
Cerebral small vessel disease (SVD) contributes to 25% of ischemic strokes and 45% dementias. We aimed investigate the role cerebral blood flow (CBF) intracranial pulsatility in SVD. scanned 60 patients with minor stroke, representing a range white matter hyperintensities (WMH). rated WMH perivascular spaces (PVS) using semi-quantitative scales measured volume. main vessels cerebrospinal fluid (CSF) phase-contrast MRI. investigated association between flow, SVD features. In 56/60 (40 male,...