A5033160431- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Maternal and Perinatal Health Interventions
- Diabetic Foot Ulcer Assessment and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Teratomas and Epidermoid Cysts
- Neurofibromatosis and Schwannoma Cases
- Bone fractures and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Primary Care and Health Outcomes
- Emergency and Acute Care Studies
- Foot and Ankle Surgery
- Peripheral Nerve Disorders
- Fetal and Pediatric Neurological Disorders
- Infectious Diseases and Tuberculosis
- Healthcare Policy and Management
- Lanthanide and Transition Metal Complexes
- Preterm Birth and Chorioamnionitis
- Hedgehog Signaling Pathway Studies
- Case Reports on Hematomas
- Spinal Hematomas and Complications
- Hospital Admissions and Outcomes
- Ocular Oncology and Treatments
NHS Lothian
2020
University of Edinburgh
1996-2020
Western General Hospital
1996-2016
Gibson Energy (Canada)
2015
Kings Health Partners
2014
King's College London
2013-2014
Thornbury Hospital
2003
John Radcliffe Hospital
1991-1993
University of Oxford
1993
Royal Hallamshire Hospital
1991
Background and Purpose —The risk of ischemic stroke distal to an atherothrombotic carotid stenosis increases with the degree stenosis. The main mechanism is thought be embolism from fissured or ruptured plaque, but there are few published data on relationship between plaque morphology severity their independent effects stroke. We sought determine interrelation surface morphology, stenosis, ipsilateral Methods —Severity were assessed angiograms symptomatic artery in 3007 patients European...
There is confusion about how carotid stenosis should be measured on angiograms. If the results of research based different methods measurement are to discussed and clinical trials properly applied routine practice, measurements made by must formally compared. The method used in European Carotid Surgery Trial (ECST), that North American Symptomatic Endarterectomy (NASCET), a common (CC) artery lumen diameter were was two observers, working independently using three measurement, angiographic...
The characteristics of intracerebral hemorrhage (ICH) may vary by ICH location because differences in the distribution underlying cerebral small vessel diseases. Therefore, we investigated incidence, characteristics, and outcome lobar nonlobar ICH.In a population-based, prospective inception cohort study ICH, used multiple overlapping sources case ascertainment follow-up to identify validate diagnoses 2010 2011 an adult population 695 335.There were 128 participants with first-ever primary...
The use of three methods measuring carotid stenosis, which produce different values on the same angiograms, has caused confusion and reduced generalizability results research. If future studies are to be properly applied clinical practice, if noninvasive imaging validated against angiography, a single, standard method measurement stenosis angiograms must adopted. This should selected bases its ability predict risk ipsilateral distribution ischemic stroke reproducibility. used in European...
The thoracic outlet syndromes encompass the diverse clinical entities affecting branchial plexus or subclavian artery including cervical ribs bands. Thoracic syndrome are often difficult to diagnose on existing and electrophysiological criteria new diagnostic methods necessary. This study reports our experience with magnetic resonance imaging (MRI) of brachial in 20 patients suspected syndrome. distribution pain sensory disturbance varied widely, weakness wasting usually affected C8/T1...
Although neuroanatomical and cognitive sequelae of low birthweight preterm birth have been investigated, little is understood as to the likely prevalence a history or birth, correlates such history, within special educational needs population. Our aim was address these issues in sample young people receiving additional learning support. One hundred thirty-seven participants aged 13–22 years, support, were recruited via their schools colleges underwent structural magnetic resonance imaging...
Maternity care has to be available 24 hours a day, seven days week. It is known that obstetric intervention can influence the time of birth, but no previous analysis at national level in England yet investigated detail ways which day and birth varies by onset labour mode giving birth.
Background The performance of maternity services is seen as a touchstone whether or not we are delivering high-quality NHS care. Staffing has been identified in numerous reports being critical component safe, effective, user-centred There little evidence regarding the impact workforce staffing and skill mix on safety, quality cost care UK. Objectives To understand relationship between organisational factors, mix, indicators safe Design methods Data included Hospital Episode Statistics (HES)...
Background Studies of daily variations in the numbers births England and Wales since 1970s have found a pronounced weekly cycle, with being highest from Tuesdays to Fridays lowest at weekends on public holidays. Mortality appeared be higher weekends. As time birth was not included national data systems until 2005, there been no previous analyses by day. Objectives To link registration notification about care during any subsequent hospital admissions quality assure linkage. use linked analyse...
Confident intra-operative localisation of thoracic spinal pathology remains challenging. Several strategies are routinely employed, including fluoroscopy and pre-operative image-guided skin marking. These techniques limited both by potential inaccuracy inconvenience. Here we present a novel, efficient accurate technique for using CT-guided placement flexible hook-wire marker.
In August 1999, a 26-year-old Caucasian woman presented with abdominal pain, diarrhoea and weight loss. Active small bowel Crohn's disease (CD) was diagnosed on barium follow-through confirmed histologically following ileal resection in October 1999. Subsequent radiological endoscopic investigations demonstrated extensive foregut involvement stricturing disease. Despite treatment 6-mercaptopurine (6-MP) (1.25 mg/kg/day) corticosteroids, control of activity suboptimal four further...
Background Hospital-based studies have reported variable associations between outcome after spontaneous intracerebral hemorrhage and peri-hematomal edema volume. Aims In a community-based study, we aimed to investigate the existence, strength, direction, independence of volumes on diagnostic brain CT one-year functional long-term survival. Methods We identified all adults, resident in Lothian, diagnosed with first-ever, symptomatic June 2010 May 2013 community-based, prospective inception...
Computed tomography of 30 patients presenting acutely with benign intracranial hypertension was compared that normal controls matched for age and sex. Qualitative quantitative assessments showed smaller cranial CSF spaces in the cases hypertension, suggesting cerebral swelling is involved pathogenesis hypertension.
AbstractA case of intracranial oculomotor nerve neurinoma arising in the interpeduncular fossa presented over course a year as an palsy. Although computerised tomography and pre-contrast magnetic resonance imaging were negative, post-contrast revealed tumour which was less than 1 cm maximum diameter. The safely removed on basis appearances. This emphasises that is useful detection such lesions at early stage their development.Key Words: neurinomaoculomotor nervemagnetic
An unusual presentation of a life-threatening cerebellopontine abscess shows the importance re-evaluating existing diagnoses when clinical picture changes. Despite being rare, brain is potentially fatal condition that requires early radiological and surgical intervention. It has varied presentation, with many cases showing no localising typical features, making it hard to diagnose at presentation. A high index suspicion should be applied exhibiting rapidly changing neurology. This first...
Summary The rate of normal birth outcomes (i.e. full-term births without intervention) for women with severe mental illness (SMI – psychotic and bipolar disorders) is not known. We examined rates intervention (spontaneous labour onset, spontaneous vaginal delivery instruments, no episiotomy indication pre- or post-delivery anaesthesia) in SMI (584 pregnancies) compared a control population (70 942 pregnancies). Outcome ratios were calculated standardising age. Women less likely to have...