A5061051737- Pharmacovigilance and Adverse Drug Reactions
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Pharmaceutical studies and practices
- Health Systems, Economic Evaluations, Quality of Life
- Stroke Rehabilitation and Recovery
- Statistical Methods in Clinical Trials
- Drug-Induced Adverse Reactions
- Pharmaceutical Economics and Policy
- Cardiovascular Health and Disease Prevention
- Meta-analysis and systematic reviews
- Computational Drug Discovery Methods
- Atrial Fibrillation Management and Outcomes
- Neurological Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Traumatic Brain Injury and Neurovascular Disturbances
- Child and Adolescent Psychosocial and Emotional Development
- Biosimilars and Bioanalytical Methods
- Maternal Mental Health During Pregnancy and Postpartum
- Inflammatory mediators and NSAID effects
- Medication Adherence and Compliance
- Advanced Causal Inference Techniques
- Hip and Femur Fractures
- Pharmaceutical Practices and Patient Outcomes
European Medicines Agency
2005-2022
Environment Agency
2010
Western General Hospital
1989-1998
The Scatter Works (United States)
1998
University of Edinburgh
1993-1997
University College London
1992
National Hospital for Neurology and Neurosurgery
1992
Charing Cross Hospital
1989
Royal London Hospital
1989
Background and Purpose The EuroQol measures aspects of quality life that are highly relevant to stroke patients. It is short simple many patients can complete the form without help. However, its validity has not been adequately assessed after stroke. We therefore concurrent discriminant in a group prospectively studied survivors. Methods series 152 with who were all visited by study nurse. nurse gave EuroQol, Frenchay Activities Index, visual analogue pain scale, Hospital Anxiety Depression...
OBJECTIVE--To determine in patients with first ever stroke whether atrial fibrillation influences clinical features, the need to perform computed tomography, and prognosis. DESIGN--Observational cohort study maximum follow up of 6.5 years. SETTING--Primary care, based on 10 general practices urban rural Oxfordshire. SUBJECTS--Consecutive series 675 registered Oxfordshire community project. MAIN OUTCOME MEASURES--Prevalence by type stroke; effect case fatality rate risk recurrent stroke,...
<h3>Abstract</h3> <b>Objective:</b> To examine the effect of contact with a stroke family care worker on physical, social, and psychological status patients their carers. <b>Design:</b> Randomised controlled trial broad entry criteria blinded outcome assessment six months after randomisation. <b>Setting:</b> A well organised service in an Edinburgh teaching hospital <b>Subjects:</b> 417 acute previous 30 days randomly allocated to be contacted by (210) or receive standard (207). The...
Background and Purpose —The reliability of the EuroQol SF-36 questionnaires after stroke is not known. We therefore aimed to assess compare test-retest both instruments in a group patients. Methods —A total 2253 patients with entered by United Kingdom hospitals International Stroke Trial were randomized follow up either or instruments. For instruments, we randomly selected one third respondents asked them complete another, identical questionnaire. assessed using agreement statistics:...
Background and Purpose Cerebral small-vessel disease (SVD) is a common aging phenomenon that exacerbated by hypertension diabetes mellitus. It regarded as an important cause of lacunar infarction intracerebral hemorrhage. The present study was performed to highlight the existence some extent frequency pathologically verified SVD lacking in classic risk factors extend scope factor analysis. Methods group comprised 70 consecutively referred autopsy brains with microscopic evidence SVD. In each...
Background: Graduated compression stockings are widely used for deep venous thrombosis (DVT) prophylaxis. Although below-knee more often than thigh-length stockings, no reliable evidence indicates that they as effective stockings. Objective: To compare the effectiveness of with preventing proximal DVT in immobile, hospitalized patients stroke. Design: Parallel-group trial centralized randomization (minimization within centers) to ensure allocation concealment. The ultrasonographers who...
Over a period of 5 years, the Innovative Medicines Initiative PROTECT (Pharmacoepidemiological Research on Outcomes Therapeutics by European ConsorTium) project has addressed key research questions relevant to science safety signal detection. The results studies conducted into quantitative detection in spontaneous reporting, clinical trial and electronic health records databases are summarised 39 recommendations have been formulated, many based comparative analyses across range (e.g....
Studies on drug utilization usually do not allow direct cross-national comparisons because of differences in the respective applied methods. This study aimed to compare time trends BZDs prescribing by applying a common protocol and analyses plan seven European electronic healthcare databases.Crude standardized prevalence rates from 2001-2009 were calculated databases Spain, United Kingdon (UK), The Netherlands, Germany Denmark. Prevalence was stratified age, sex, BZD type [(using ATC codes),...
It is often difficult to determine the health-related quality of life (HRQoL) stroke patients because physical and cognitive problems limit their ability complete complex questionnaires. A proxy, such as a family member or caregiver, may be able give an estimate patients' health status. We therefore examined agreement between HRQoL assessed by series that proxies.We studied validity EuroQol in 152 from our prospective registry with first (or recurrent) stroke. asked ensure friend relative (a...
To determine whether diurnal variation occurs in the onset of stroke.Community based study over four years.Oxfordshire, United Kingdom.105,000 people, whom 675 had a first ever stroke. 545 cerebral infarction, 66 primary intracerebral haemorrhage, 33 subarachnoid and 31 type stroke was not known.Time degree activity at onset.In 578 patients for it known occurred while asleep or awake, proportion with during sleep 25% (135/545) 17% (11/66) 0% (0/33) haemorrhage. This difference persisted if...
The use of three methods measuring carotid stenosis, which produce different values on the same angiograms, has caused confusion and reduced generalizability results research. If future studies are to be properly applied clinical practice, if noninvasive imaging validated against angiography, a single, standard method measurement stenosis angiograms must adopted. This should selected bases its ability predict risk ipsilateral distribution ischemic stroke reproducibility. used in European...
The Oxfordshire Community Stroke Project (OCSP) clinical classification of subtypes cerebral infarction (total and partial anterior circulation infarction, lacunar posterior infarction) can be used to predict early mortality, functional outcome, whether the infarct was likely due large- or small-vessel occlusion. OCSP originally developed tested by neurologists as part a community-based study first-ever stroke, in which some cases were seen after acute phase. We examined interobserver...
OBJECTIVES--To compare the operative thresholds and clinical management of men undergoing elective transurethral resection prostate for benign prostatic hypertrophy in NHS privately. DESIGN--Cohort study patients recruited by 25 surgeons during 1988. SETTING--Hospitals Oxford North West Thames regions. PATIENTS--Of 400 consecutive patients, 129 were excluded because open surgery (nine), lack surgeons9 information (three), emergency admission (117) three failed to give information, leaving...
We assessed the validity and reliability of simple questions to assess outcome after stroke in a group 60 patients. 100 consecutive patients admitted hospital with acute were prospectively studied, survivors randomised follow-up either by postal questionnaire or telephone interview. The responses assessment from who could participate study compared Barthel Index (BI) Oxford Handicap Scale (OHS) obtained face-to-face interview trained nurse (who was ''blind'' responses). response item: ''In...
Tendon rupture can result from fluoroquinolone exposure. The objective of this study was to quantify relative and absolute risk determine how is affected by timing
Peripheral neuropathy has been associated with systemic fluoroquinolone exposure, but risk poorly quantified.To calculate relative and absolute estimates for the association of exposure peripheral to examine how may be affected by timing other factors.This nested case-control study used anonymized data from all patients routinely registered general practices in The Health Improvement Network database, a large primary care population database United Kingdom, January 1, 1999, December 31,...
The impact of a disease on health related quality life is important but difficult to measure. If the instrument used for measuring this too complicated some people may not answer questions and others respond at all. Although incomplete data introduce biases, make interpretation difficult, reduce generalisability results,1 papers selecting instruments have ignored response frequency.2 (2, 3) We postulated that brevity simplicity EuroQol questionnaire (six separate visual analogue scale) would...