A5019050826- Posttraumatic Stress Disorder Research
- Stress Responses and Cortisol
- Smoking Behavior and Cessation
- Suicide and Self-Harm Studies
- Heart Rate Variability and Autonomic Control
- Epigenetics and DNA Methylation
- Migration, Health and Trauma
- Resilience and Mental Health
- Child Abuse and Trauma
- Traumatic Brain Injury Research
- Cardiac Health and Mental Health
- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- Nicotinic Acetylcholine Receptors Study
- Sleep and related disorders
- Birth, Development, and Health
- Identity, Memory, and Therapy
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Sleep and Work-Related Fatigue
- Cannabis and Cannabinoid Research
- Health, Environment, Cognitive Aging
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Attention Deficit Hyperactivity Disorder
- Family Support in Illness
Durham VA Health Care System
2015-2024
Duke University
2009-2024
Mental Illness Research, Education and Clinical Centers
2016-2024
University School
2024
The University of Texas at Austin
2024
Duke Medical Center
2012-2023
University of Utah
2023
Virginia Commonwealth University
2023
Huntsman (United States)
2023
Durham VA Medical Center
2010-2021
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion, multiomic study posttraumatic stress disorder (PTSD) and major depressive (MDD) included the central nucleus amygdala, hippocampal dentate gyrus, medial prefrontal cortex (mPFC). Genes exons within mPFC carried most disease signals replicated across two independent cohorts. Pathways pointed to immune function, neuronal synaptic regulation, hormones. Multiomic factor gene network analyses provided...
Abstract People who experience trauma and develop posttraumatic stress disorder (PTSD) are at increased risk for poor health. One mechanism that could explain this is accelerated biological aging, which associated with the accumulation of chronic diseases, disability, premature mortality. Using data from 2309 post-9/11 United States military veterans participated in VISN 6 MIRECC’s Post-Deployment Mental Health Study, we tested whether PTSD exposure were rate assessed using a validated DNA...
<h3>Abstract</h3> <b>Objective:</b> To examine the effect of contact with a stroke family care worker on physical, social, and psychological status patients their carers. <b>Design:</b> Randomised controlled trial broad entry criteria blinded outcome assessment six months after randomisation. <b>Setting:</b> A well organised service in an Edinburgh teaching hospital <b>Subjects:</b> 417 acute previous 30 days randomly allocated to be contacted by (210) or receive standard (207). The...
Objective: Mindfulness meditation training is garnering increasing empirical interest as an intervention for ADHD in adulthood, although no studies of mindfulness a standalone treatment have included sample composed entirely adults with or comparison group. The aim this study was to assess the feasibility, acceptability, and preliminary efficacy ADHD, executive functioning (EF), emotion dysregulation symptoms adult sample. Method: Adults were stratified by medication status otherwise...
Smokers with posttraumatic stress disorder (PTSD) smoke at higher prevalence rates and are more likely to relapse early in a quit attempt. Innovative methods needed enhance rates, particularly the period. Web-based contingency-management (CM) approaches have been found helpful reducing smoking among other difficult-to-treat smoker populations but limited by need for computers. This pilot study builds on web-based CM approach evaluating smartphone-based application named mobile (mCM)....
The present study examined the structural validity of 25-item Connor–Davidson Resilience Scale (CD-RISC) in a large sample U.S. veterans with military service since September 11, 2001. Participants ( N = 1,981) completed CD-RISC, structured clinical interview and self-report questionnaire assessing psychiatric symptoms. was randomly divided into two subsamples: an initial (Sample 1: n 990) replication 2: 991). Findings derived from exploratory factor analysis (EFA) did not support...
Abstract Background The causal effects of gut microbiome and the development posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential association using mendelian randomization (MR). Methods summary-level statistics for were retrieved from a genome-wide (GWAS) MiBioGen consortium. As PTSD, Freeze 2 datasets originated Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group (PGC-PTSD), replicated obtained FinnGen Single nucleotide...
This study evaluated the relationship between resilience and psychological functioning in military veterans deployed to a region of conflict support Operation Enduring Freedom or Iraqi Freedom.497 completed structured psychiatric interview questionnaires measuring symptoms, resiliency, trauma exposure. The had 2 primary aims: (1) examine whether association exposure PTSD was moderated by (2) uniquely associated with functional outcomes after accounting for PTSD. Measures included Structured...
Objective Posttraumatic stress disorder (PTSD) has been linked to reduced heart rate variability (HRV), which is in turn a risk factor for cardiovascular disease and death. Although hyperarousal anxiety are thought underlie this association, behavioral health risks, including smoking, alcohol dependence, obesity, sleep disturbance, represent potential mechanisms linking PTSD HRV. Methods To test hypothesis, short-term laboratory-based 24-hour ambulatory measures of HRV were collected from...
Compelling evidence suggests that epigenetic mechanisms such as DNA methylation play a role in stress regulation and the etiologic basis of related disorders Post traumatic Stress Disorder (PTSD). Here we describe purpose methods an international consortium was developed to study epigenetics PTSD. Inspired by approach used Psychiatric Genomics Consortium, brought together investigators representing seven cohorts with collective sample size N = 1147 included detailed information on trauma...
Abstract We present an ensemble transfer learning method to predict suicide from Veterans Affairs (VA) electronic medical records (EMR). A diverse set of base models was trained a binary outcome constructed reported suicide, attempt, and overdose diagnoses with varying choices study design prediction methodology. Each model used twenty cross-sectional 190 longitudinal variables observed in eight time intervals covering 7.5 years prior the prediction. Ensembles seven were created fine-tuned...
Although selective serotonin reuptake inhibitors have been the most empirically studied pharmacotherapy for posttraumatic stress disorder (PTSD), a need remains investigation of additional pharmacological agents in treatment PTSD. The present study examined use bupropion sustained release (SR) as compared with placebo symptom reduction patients PTSD: approximately half who were already prescribed an inhibitor and not.Thirty (mean age, 50 years) civilian- or military-related PTSD enrolled...
Although sleep disturbance is considered a hallmark of posttraumatic stress disorder (PTSD), objective evidence for in patients with PTSD has been equivocal. The goal the current investigation was to objectively examine among women their home environment. Women (n = 30) and control group 22) completed three nights actigraphy monitoring. Results from indicated that had poorer efficiency, increased latency, more restless sleep. Actigraphy measures were moderately correlated self-report...
This study evaluated the effect of childhood trauma exposure and role resilience on both depressive symptoms suicidal ideation. The 1,488 military personnel veterans, who served after September 2001, for depressive, suicidal, PTSD symptoms, combat exposure, resiliency. Participants were enrolled as part an ongoing multicenter study. Outcome measures After controlling effects PTSD, results revealed that exposures significantly associated with In addition, was negatively ideation, suggesting a...
Background This study was designed to examine the concordance of proposed DSM-V posttraumatic stress disorder (PTSD) criteria with DSM-IV classification rules and impact PTSD on prevalence. Method The sample (N = 185) included participants who were recruited for studies focused trauma health conducted at an academic medical center VA in southeastern United States. prevalence between classifications calculated based results from structured clinical interviews. Prevalence rates diagnostic...
Retrospective research suggests smokers with posttraumatic stress disorder (PTSD) lapse more quickly after their quit date. Ecological momentary assessment (EMA) is needed to confirm the presence of early smoking in PTSD and form conceptualizations that inform intervention. Smokers (n = 55) without 52) completed alarm-prompted EMA situational psychiatric variables week before a date, self-initiated following lapses. Blood samples at baseline on date allowed dehydroepiandrosterone (DHEA)...
Article AbstractIntroduction: Smoking rates are 80% among persons who homeless, and these smokers have decreased odds of quitting smoking. Little is known about relapse homeless smokers. More information needed regarding both quit innovative methods to treat smoking cessation Web-based contingency management (CM) approaches been found helpful in reducing other difficult-to-treat smoker populations but generally limited by the need for computers or frequent clinic-based carbon monoxide (CO)...