A5026464787- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Birth, Development, and Health
- Tryptophan and brain disorders
- Posttraumatic Stress Disorder Research
- Migration, Health and Trauma
- Child Abuse and Trauma
- Identity, Memory, and Therapy
- Resilience and Mental Health
- Health, Environment, Cognitive Aging
- Child and Adolescent Psychosocial and Emotional Development
- Genetic Associations and Epidemiology
- Childhood Cancer Survivors' Quality of Life
- Family Support in Illness
- Health disparities and outcomes
- Influenza Virus Research Studies
- Genomics and Phylogenetic Studies
- Anesthesia and Neurotoxicity Research
- Adolescent and Pediatric Healthcare
- Early Childhood Education and Development
- Bioinformatics and Genomic Networks
- RNA and protein synthesis mechanisms
- Metabolomics and Mass Spectrometry Studies
- Gene expression and cancer classification
- Maternal Mental Health During Pregnancy and Postpartum
University of South Florida
2019-2025
University of Illinois Urbana-Champaign
2014-2024
Florida College
2019-2024
Biogen (United States)
2024
VA Boston Healthcare System
2024
Boston University
2010-2024
National Center for PTSD
2024
Acadia Pharmaceuticals (United States)
2024
Boehringer Ingelheim (South Korea)
2024
Emory University
2024
The biologic underpinnings of posttraumatic stress disorder (PTSD) have not been fully elucidated. Previous work suggests that alterations in the immune system are characteristic disorder. Identifying mechanisms by which such occur could provide fundamental insights into etiology and treatment PTSD. Here we identify specific epigenetic profiles underlying changes associated with Using blood samples ( n = 100) obtained from an ongoing, prospective epidemiologic study Detroit, Detroit...
During the influenza A(H1N1) pandemic, antiviral prescribing was limited, vaccines were not available early, and effectiveness of nonpharmaceutical interventions (NPIs) uncertain. Our study examined whether use face masks hand hygiene reduced incidence influenza-like illness (ILI).A randomized intervention trial involving 1437 young adults living in university residence halls during 2006-2007 season designed. Residence randomly assigned to 1 3 groups-face mask use, with hygiene, or control-...
Evidence from comparative studies of gene expression and evolution suggest that human neocortical neurons may be characterized by unusually high levels energy metabolism. The current study examined whether there is a disproportionate increase in glial cell density the frontal cortex comparison with other anthropoid primate species (New World monkeys, Old hominoids) to support greater metabolic demands. Among 18 anthropoids, humans displayed greatest departure allometric scaling expectations...
Limited vaccine availability and the potential for resistance to antiviral medications have led calls establishing efficacy of non-pharmaceutical measures mitigating pandemic influenza. Our objective was examine if use face masks hand hygiene reduced rates influenza-like illness (ILI) laboratory-confirmed influenza in natural setting. A cluster-randomized intervention trial designed involving 1,178 young adults living 37 residence houses 5 university halls during 2007–2008 season....
Abstract Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples European ancestry. Here we report a multi-ancestry GWAS MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used range measures define included African (36% effective sample size), East Asian (26%) South (6%) ancestry Hispanic/Latin American participants (32%). The identified 53 significantly associated novel loci. For...
What do functionally important DNA sites, those scrutinized and shaped by natural selection, tell us about the place of humans in evolution? Here we compare ≈90 kb coding nucleotide sequence from 97 human genes to their sequenced chimpanzee counterparts available gorilla, orangutan, Old World monkey counterparts, and, on a more limited basis, mouse. The nonsynonymous changes (functionally important), like synonymous much less show chimpanzees be most closely related, sharing 99.4% identity...
Gene expression profiles from the anterior cingulate cortex (ACC) of human, chimpanzee, gorilla, and macaque samples provide clues about genetic regulatory changes in human other catarrhine primate brains. The ACC, a cerebral neocortical region, has human-specific histological features. Physiologically, an individual's ACC displays increased activity during that performance cognitive tasks. Of ≈45,000 probe sets on microarray chips representing transcripts all or most genes, ≈16,000 were...
Galectins are proteins that regulate immune responses through the recognition of cell-surface glycans. We present evidence 16 human galectin genes expressed at maternal-fetal interface and demonstrate a cluster 5 on chromosome 19 emerged during primate evolution as result duplication rearrangement pseudogenes via birth death process primarily mediated by transposable long interspersed nuclear elements (LINEs). Genes in found only anthropoids, group species differ from their strepsirrhine...
Abstract Exposure to traumatic events is common, particularly among economically disadvantaged, urban African Americans. There is, however, scant data on the psychological consequences of exposure in this group. We assessed experience with and posttraumatic stress disorder (PTSD) 1,306 randomly selected, American residents Detroit. Lifetime prevalence at least 1 event was 87.2% (assault = 51.0%). Americans from Detroit have a relatively high burden PTSD; 17.1% those who experienced met...
Recent work suggests that epigenetic differences may be associated with psychiatric disorders. Here we investigate, in a community-based sample, whether methylation profiles distinguish between individuals and without lifetime depression. We also investigate the physiologic consequences these profiles.Using whole blood-derived genomic DNA from subset of participants Detroit Neighborhood Health Study (DNHS), applied microarrays to assess genome-wide for over 14 000 genes 33 persons who...
Previous molecular analyses of mammalian evolutionary relationships involving a wide range placental taxa have been restricted in size from one to two dozen gene loci and not decisively resolved the basal branching order within Placentalia. Here, on extracting thousands both their coding nucleotide sequences translated amino acid sequences, we attempt resolve key uncertainties about ancient pattern crown mammals. Focusing approximately 1,700 conserved loci, those that more slowly evolving...
Posttraumatic stress disorder (PTSD) is a common and debilitating mental that occurs following exposure to traumatic event. However, most individuals do not develop PTSD even severe trauma, leading search for new variables, such as genetic other molecular variation, associated with vulnerability resilience in the face of trauma exposure.We examined whether serotonin transporter (SLC6A4) promoter genotype methylation status modified association between number events experienced subset 100...
Previous studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic stress disorder (PTSD).