A5078299199- Traumatic Brain Injury Research
- Posttraumatic Stress Disorder Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cardiac Arrest and Resuscitation
- Dementia and Cognitive Impairment Research
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Epigenetics and DNA Methylation
- Resilience and Mental Health
- Birth, Development, and Health
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Suicide and Self-Harm Studies
- Advanced MRI Techniques and Applications
- Child Abuse and Trauma
- Heart Rate Variability and Autonomic Control
- Alzheimer's disease research and treatments
- Migration, Health and Trauma
- Cardiovascular Health and Disease Prevention
- Tryptophan and brain disorders
- Cerebrovascular and Carotid Artery Diseases
- Visual perception and processing mechanisms
- Childhood Cancer Survivors' Quality of Life
VA Boston Healthcare System
2015-2024
Harvard University
2015-2024
Geriatric Research Education and Clinical Center
2015-2024
Athinoula A. Martinos Center for Biomedical Imaging
2011-2023
National Center for PTSD
2017-2023
Boston University
2011-2023
The Ohio State University
2023
Massachusetts General Hospital
2011-2023
Lemuel Shattuck Hospital
2023
National Center for Post Traumatic Stress Disorder
2017-2022
Objective: Report the prevalence of lifetime and military-related traumatic brain injuries (TBIs) in Operation Enduring Freedom Iraqi (OEF/OIF) veterans validate Boston Assessment TBI–Lifetime (BAT-L). Setting: The BAT-L is first validated, postcombat, semistructured clinical interview to characterize head diagnose TBIs throughout life span. Participants: Community-dwelling convenience sample 131 OEF/OIF veterans. Design: TBI criteria (alteration mental status, posttraumatic amnesia, loss...
Abstract Understanding the factors that influence veterans’ functional outcome after deployment is critical to provide appropriately targeted care. Mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) have been related disability, but other psychiatric behavioral conditions are not as well examined. We investigated impact of deployment‐related on disability among 255 OEF/OIF/OND service members veterans. Structured clinical interviews assessed TBI depression, PTSD,...
Abstract Cerebral white matter damage is not only a commonly reported consequence of healthy aging, but also associated with cognitive decline and dementia. The aetiology this unclear; however, individuals hypertension have greater burden signal abnormalities (WMSA) on MR imaging than those without hypertension. It therefore possible that elevated blood pressure (BP) impacts tissue structure which in turn has negative impact cognition. However, little information exists about whether...
Abstract Many US veterans of Afghanistan and Iraq have multiple physical psychiatric problems. A major focus research has been on determining the effects mild Traumatic Brain Injury (mTBI), but mTBI is rarely diagnosed in absence co‐occurring conditions such as blast exposure, post‐traumatic stress disorder (PTSD), depression, substance abuse, etc. These potentially interactive psychological produce complex patterns cognitive, psychological, symptoms that impede civilian reintegration...
We examined concordance of methylation levels across the Illumina Infinium HumanMethylation450 BeadChip and MethylationEPIC BeadChip.We computed correlation for 145 whole blood DNA samples at each 422,524 CpG sites measured by both chips.The some was high (up to r = 0.95), but many had low (55% < 0.20). The correspondence between 450K EPIC values loci largely due variability in majority blood.Filtering out probes based on observed or may increase reproducibility BeadChip-based...
Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) in military personnel is increasing dramatically following the OEF/OIF conflicts associated with alterations to structure. The present study examined relationship between PTSD cortical thickness, its possible modification by mTBI, a 104-subject veteran cohort ranging age from 20 62 years. For each participant, two T1-weighted scans were averaged create high-resolution images for calculation of regional thickness....
Moderate-to-severe traumatic brain injury is one of the strongest environmental risk factors for development neurodegenerative diseases such as late-onset Alzheimer's disease, although it unclear whether mild injury, or concussion, also confers risk. This study examined and genetic predictors reduced cortical thickness in regions previously associated with early their relationship episodic memory. Participants were 160 Iraq Afghanistan War veterans between ages 19 58, many whom carried...
The human hippocampus is vulnerable to a range of degenerative conditions and as such, accurate in vivo measurement the hippocampal substructures via neuroimaging great interest for understanding mechanisms disease well use biomarker clinical trials novel therapeutics. Although total volume can be measured relatively reliably, it critical understand how this reliability affected by acquisition on different scanners, multiple scanning platforms would likely utilized large-scale trials. This...
Previous studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic stress disorder (PTSD).
Background: Chronic misuse of alcohol results in widespread damage to the brain. Prior morphometric studies have examined cortical atrophy individuals with alcoholism; however, no previous alcohol‐associated using thickness measurements obtain regional mapping tissue loss across full surface. Methods: We compared measures from 31 abstinent a history prior abuse 34 healthy nonalcoholic control participants (total sample size = 65). Cortical surface models were created high‐resolution...
Abstract Although there is mounting evidence that greater PTSD symptoms are associated with reduced executive functioning, it not fully understood whether this association more global or specific to certain function subdomains, such as inhibitory control. We investigated the generality of between and by administering a broad battery sensitive functioning tasks cohort returning Operation Enduring Freedom/Operation Iraqi Freedom Veterans varying symptoms. Only related control explained...
Mild traumatic brain injury, or concussion, is associated with a range of neural changes including altered white matter structure. There emerging evidence that blast exposure—one the most pervasive causes casualties in recent overseas conflicts Iraq and Afghanistan—is accompanied by neurobiological events may result pathological to structure function occur independently overt concussion symptoms. The potential effects injury due exposure are great concern as history mild has been identified...
Abstract Although there is emerging data on the effects of blast‐related concussion (or mTBI) cognition, blast exposure itself brain have only recently been explored. Toward this end, we examine functional connectivity to posterior cingulate cortex, a primary region within default mode network (DMN), in cohort 134 Iraq and Afghanistan Veterans characterized for range common military‐associated comorbidities. Exposure at close (<10 meters) was associated with decreased bilateral...
Background Evidence suggests that chronic misuse of alcohol may preferentially affect the integrity frontal white matter ( WM ) tracts, which can impact executive functions important to achieve and maintain abstinence. Methods Global regional microstructure was assessed using diffusion magnetic resonance measures fractional anisotropy FA for 31 abstinent alcoholics (ALC) with an average 25 years abuse approximately 5 sobriety 20 nonalcoholic control NC participants. Data processing conducted...