A5066579892- Posttraumatic Stress Disorder Research
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Traumatic Brain Injury Research
- Migration, Health and Trauma
- Tryptophan and brain disorders
- Resilience and Mental Health
- Child Abuse and Trauma
- Anesthesia and Neurotoxicity Research
- Healthcare professionals’ stress and burnout
- Suicide and Self-Harm Studies
- Psychosomatic Disorders and Their Treatments
- Personality Disorders and Psychopathology
- Childhood Cancer Survivors' Quality of Life
- Traumatic Brain Injury and Neurovascular Disturbances
- Psychotherapy Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Mental Health Treatment and Access
- Cognitive Abilities and Testing
- Mental Health Research Topics
- Dementia and Cognitive Impairment Research
VA Boston Healthcare System
2016-2025
National Center for PTSD
2016-2025
Boston University
2016-2025
Florida College
2024
University of South Florida
2024
Acadia Pharmaceuticals (United States)
2024
Jazz Pharmaceuticals (United States)
2024
Sage Therapeutics (United States)
2024
Janssen (Belgium)
2024
University of California, San Diego
2018-2024
Determining sample size requirements for structural equation modeling (SEM) is a challenge often faced by investigators, peer reviewers, and grant writers. Recent years have seen large increase in SEMs the behavioral science literature, but consideration of applied relies on outdated rules-of-thumb. This study used Monte Carlo data simulation techniques to evaluate common SEMs. Across series simulations, we systematically varied key model properties, including number indicators factors,...
To describe the prevalence of posttraumatic stress disorder (PTSD) and comorbid psychiatric disorders identify correlates PTSD in a contemporary, nationally representative sample US veterans.Data were analyzed from Wave 1 National Health Resilience Veterans Study, cross-sectional, retrospective, web-based survey population-based 3,157 veterans conducted between October December 2011. The main outcome measure was probable lifetime PTSD, which assessed by using DSM-IV version Checklist (PCL),...
<h3>Context</h3>The nature of the relationship dissociation to posttraumatic stress disorder (PTSD) is controversial and considerable clinical nosologic importance.<h3>Objectives</h3>To examine evidence for a dissociative subtype PTSD its association with different types trauma.<h3>Design</h3>A latent profile analysis cross-sectional data from structured interviews indexing DSM-IV symptoms current dissociation.<h3>Settings</h3>The VA Boston Healthcare System New Mexico Health Care...
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion, multiomic study posttraumatic stress disorder (PTSD) and major depressive (MDD) included the central nucleus amygdala, hippocampal dentate gyrus, medial prefrontal cortex (mPFC). Genes exons within mPFC carried most disease signals replicated across two independent cohorts. Pathways pointed to immune function, neuronal synaptic regulation, hormones. Multiomic factor gene network analyses provided...
Background The nature of the relationship between dissociation and posttraumatic stress disorder (PTSD) has clinical nosological importance. aim this study was to evaluate evidence for a dissociative subtype PTSD in two independent samples examine pattern personality (PD) comorbidity associated with PTSD. Methods Latent profile analyses were conducted on items reflecting derealization depersonalization archived data: Study 1 included 360 male Vietnam War Veterans combat-related PTSD; 2 284...
The 11th edition of the International Classification Diseases ( ICD–11) is under development, and current proposals include major changes to trauma-related psychiatric diagnoses, including a heavily restricted definition posttraumatic stress disorder (PTSD) addition complex PTSD (CPTSD). We aimed test postulates CPTSD in samples 2,695 community participants 323 trauma-exposed military veterans. prevalence estimates were 0.6% 13% veteran samples, respectively; one quarter half those with met...
We examined concordance of methylation levels across the Illumina Infinium HumanMethylation450 BeadChip and MethylationEPIC BeadChip.We computed correlation for 145 whole blood DNA samples at each 422,524 CpG sites measured by both chips.The some was high (up to r = 0.95), but many had low (55% < 0.20). The correspondence between 450K EPIC values loci largely due variability in majority blood.Filtering out probes based on observed or may increase reproducibility BeadChip-based...
This pilot study examined two telehealth interventions to address symptoms of combat-related posttraumatic stress disorder (PTSD) in veterans. Thirty-three male combat veterans were randomly assigned one treatment conditions: mindfulness or psychoeducation. In both conditions, participants completed 8 weeks (two sessions person followed by six over the telephone) and three assessments (pretreatment, posttreatment, 6-week follow-up). The was based on tenets mindfulness-based reduction...
Moderate-to-severe traumatic brain injury is one of the strongest environmental risk factors for development neurodegenerative diseases such as late-onset Alzheimer's disease, although it unclear whether mild injury, or concussion, also confers risk. This study examined and genetic predictors reduced cortical thickness in regions previously associated with early their relationship episodic memory. Participants were 160 Iraq Afghanistan War veterans between ages 19 58, many whom carried...
Recent proposals for revisions to the 11th edition of International Classification Diseases (ICD-11) posttraumatic stress disorder (PTSD) diagnostic criteria have argued that current symptom constellation under Diagnostic and Statistical Manual Mental Disorders-5 is unwieldy includes many symptoms overlap with other disorders. The newly proposed ICD-11 include only 6 symptoms. However, restricting those included in has implications PTSD diagnosis prevalence estimates, it remains unclear...
Background To examine shared genetic and environmental risk factors across PTSD symptoms resilience. Methods Classical twin study of 2010–2012 survey data conducted among 3,318 male pairs in the Vietnam Era Twin Registry. Analyses included: (a) estimates influences on symptom severity (as measured by Checklist) resilience (assessed with Connor-Davidson Resilience Scale-10); (b) development a latent model traumatic stress, spanning both resilience; (c) this spectrum. Results The heritability...
Previous studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic stress disorder (PTSD).
Objective: Multidisciplinary studies of posttraumatic stress disorder (PTSD) and major depressive (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease risk pathophysiology. Postmortem brain have relied on bulk-tissue RNA sequencing (RNA-seq), but single-cell RNA-seq is needed to dissect cell-type-specific mechanisms. The authors conducted first single-nucleus postmortem study PTSD elucidate transcriptomic pathology with resolution. Method: Profiling 32 DLPFC samples from 11...
Abstract This study examined the latent structure of psychiatric disorders in a sample with high prevalence PTSD. A series confirmatory factor analyses tested competing models for covariation between Structured Clinical Interview DSM‐III‐R diagnoses among 1,325 Vietnam veterans. The best‐fitting solution was 3‐factor model that included two correlated internalizing factors: anxious‐misery, defined by PTSD and major depression, fear, panic disorder/agoraphobia obsessive‐compulsive disorder....