A5003183022- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Trauma and Emergency Care Studies
- Zebrafish Biomedical Research Applications
- Emergency and Acute Care Studies
- Stress Responses and Cortisol
- Traumatic Brain Injury Research
- Posttraumatic Stress Disorder Research
- Injury Epidemiology and Prevention
- Cardiac Arrest and Resuscitation
- Gun Ownership and Violence Research
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Social Media and Politics
- Animal Genetics and Reproduction
- Healthcare Policy and Management
- Health, Environment, Cognitive Aging
- Appendicitis Diagnosis and Management
- Diet, Metabolism, and Disease
- Intestinal Malrotation and Obstruction Disorders
- Genetics and Physical Performance
- Autopsy Techniques and Outcomes
- Genetic Associations and Epidemiology
- Pluripotent Stem Cells Research
Medical College of Wisconsin
2019-2025
Children's Hospital of Wisconsin
2023-2024
Minnesota Department of Corrections
2018
Georgetown University
2009-2016
Georgetown University Medical Center
2009-2016
National Institute of Mental Health
2010
Institute of Molecular Biology and Biophysics
2009
Sun Pharma Advanced Research (India)
2009
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion, multiomic study posttraumatic stress disorder (PTSD) and major depressive (MDD) included the central nucleus amygdala, hippocampal dentate gyrus, medial prefrontal cortex (mPFC). Genes exons within mPFC carried most disease signals replicated across two independent cohorts. Pathways pointed to immune function, neuronal synaptic regulation, hormones. Multiomic factor gene network analyses provided...
Abstract The endocannabinoid signaling system (ECSS) regulates fear and anxiety. While ECSS hypoactivity can contribute to symptoms of established post-traumatic stress disorder (PTSD), the role in PTSD development following trauma is unknown. A prospective, longitudinal cohort study 170 individuals (47% non-Hispanic Caucasian 70% male) treated at a level 1 center for traumatic injury was carried out. symptom assessments blood were obtained during hospitalization follow-up (6–8 months post...
Objectives: Water beads expand by absorption and are used as toys decorations among other purposes. When ingested, they have been implicated in small bowel obstructions. Laxatives administered after ingestion to prevent obstruction. Our primary aim was evaluate the growth patterns maximal diameter of various water multiple solutions. secondary identify a liquid capable shrinking expanded beads. Methods: (10 standard-size brands; 3 jumbo) were tested for shrinking. Growth assessed 9...
Abstract Due to its heterogeneity, the prediction of posttraumatic stress disorder (PTSD) development after traumtic injury is difficult. Recent machine learning approaches have yielded insight into predicting PTSD symptom trajectories. Using data collected within 1 month traumatic injury, we applied eXtreme Gradient Boosting (XGB) classify admitted and discharged patients (hospitalized, n = 192; nonhospitalized, 214), recruited from a Level trauma center, according Trajectories were...
Abstract Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association across 1,222,882 individuals European ancestry (137,136 cases) and 58,051 admixed with African Native American (13,624 cases). identified 95 significant loci (80 novel). Convergent...
BACKGROUND Psychological distress is common following a traumatic injury event. The Injured Trauma Survivor Screen (ITSS) was developed at level 1 trauma center to assess for posttraumatic stress disorder (PTSD) and major depressive episode (MDE) admission injury. ITSS sensitivity specificity were analyzed 3 6 9 months postinjury test the validity across centers. METHOD Four centers from East, Midwest, South, West in United States recruited 375 eligible adult inpatients (excluded...
Abstract Background Multiple studies have explored demographic characteristics and social determinants of health in relation to the risk pediatric assault-related injuries reinjury. However, few protective factors. The Child Opportunity Index (COI) uses neighborhood-level indicators measure ‘opportunity’ based on factors such as education, environment, economic resources. We hypothesized that higher would be associated with less reinjury assault-injured youth. Methods This was a...
Abstract Individuals who require hospitalization after traumatic injuries are at increased risk for developing posttraumatic stress disorder (PTSD); however, few early behavioral interventions have been effective preventing PTSD within this population. The aim of pilot study was to assess the feasibility and effectiveness modified prolonged exposure therapy (mPE) prevent depression symptoms among patients hospitalized a DSM‐5 single‐incident trauma. Hospitalized were eligible if they...
The COVID-19 pandemic disrupted social, political, and economic life across the world, shining a light on vulnerability of many communities. objective this study was to assess injury patterns before after implementation stay-at-home orders (SHOs) between White children color varying levels based upon children's home residence. A multi-institutional retrospective conducted evaluating patients < 18 years with traumatic injuries. "Control" cohort from an averaged March-September 2016-2019 time...