A5048961816- Urinary Bladder and Prostate Research
- Sexual function and dysfunction studies
- Genetic Associations and Epidemiology
- Prostate Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Health disparities and outcomes
- Sleep and related disorders
- Health and Wellbeing Research
- Dementia and Cognitive Impairment Research
- Gut microbiota and health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Folate and B Vitamins Research
- Nutrition and Health in Aging
- Pelvic floor disorders treatments
- Dialysis and Renal Disease Management
- Ureteral procedures and complications
- Heavy Metal Exposure and Toxicity
- Renal Transplantation Outcomes and Treatments
- Pregnancy and Medication Impact
- Sexual Differentiation and Disorders
- Diverticular Disease and Complications
- HIV, Drug Use, Sexual Risk
- Eating Disorders and Behaviors
- Demographic Trends and Gender Preferences
- Chronic Kidney Disease and Diabetes
West China Hospital of Sichuan University
2004-2025
Sichuan University
2004-2025
Jiangxi Science and Technology Normal University
2024
Xuzhou Medical College
2024
West China Second University Hospital of Sichuan University
2024
Jiangxi Pingxiang People's Hospital
2024
University of Macau
2024
Chongqing Medical University
2018-2022
Chengdu Second People's Hospital
2020
Saitama International Medical Center
2020
Abstract Background Disability in aged people became one of the major challenges China due to acceleration population aging. Nevertheless, there were limited methods appropriately discriminate degree combined basic activity daily living (BADL) and instrumental (IADL). The present study explored an empirical typology (ADL) its association with health status among elderly China. Methods Data throughout Chinese Longitudinal Healthy Longevity Survey (CLHLS) was retrieved Latent profile analysis...
The causal association between modifiable risk factors and erectile dysfunction (ED) remains unclear, which hinders the early identification intervention of patients with ED. present study aimed to clarify 42 predominant
Background Research on the association between blood lead (Pb) and lipid biomarkers have yielded inconsistent results, epidemiological studies Pb levels hyperlipidemia are scarce. The present study aimed to examine in adults from National Health Nutrition Examination Survey (NHANES). Methods A total of 43,196 participants NHANES 1999 2018 were included final analysis. Hyperlipidemia was determined based Cholesterol Education Program guidelines. Blood assessed using inductively-coupled plasma...
The causal association between the gut microbiome and development of migraine its subtypes remains unclear.The single nucleotide polymorphisms concerning were retrieved from gene-wide study (GWAS) MiBioGen consortium. summary statistics datasets migraine, with aura (MA), without (MO) obtained GWAS meta-analysis International Headache Genetics Consortium (IHGC) FinnGen Inverse variance weighting (IVW) was used as primary method, complemented by sensitivity analyses for pleiotropy increasing...
This study aimed to investigate the association between different metabolic syndrome-body mass index (MetS-BMI) phenotypes and risk of kidney stones.Participants aged 20-80 years from six consecutive cycles NHANES 2007-2018 were included in this study. According their MetS status BMI, participants allocated into mutually exclusive groups: metabolically healthy normal weight (MHN)/overweight (MHOW)/obesity (MHO) unhealthy (MUN)/overweight (MUOW)/obesity (MUO). To explore MetS-BMI stones,...
Abstract Background The causal effects of gut microbiome and the development posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential association using mendelian randomization (MR). Methods summary-level statistics for were retrieved from a genome-wide (GWAS) MiBioGen consortium. As PTSD, Freeze 2 datasets originated Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group (PGC-PTSD), replicated obtained FinnGen Single nucleotide...
To investigate the prevalence and associated factors of lower urinary tract symptoms suggestive benign prostatic hyperplasia (LUTS/BPH) in Chinese aging males.Data downloaded from China Health Retirement Longitudinal Study (CHARLS) was subjected to descriptive statistics followed by univariate logistic regression multivariate regression.A total 8563 participants with an overall LUTS/BPH 11.97% were enrolled. With aging, increased (p < 0.001). Men aged over 70 years suffered highest 22.70%....
Background Causal research concerning the consumption of tea and risk chronic kidney disease (CKD) is limited. This study identified potential causal effects intake on CKD, estimated glomerular filtration rate (eGFR), albuminuria. Methods Genome-wide association studies (GWASs) from UK Biobank were able to identify single-nucleotide polymorphisms (SNPs) associated with an extra cup each day. The summary statistics for function CKDGen consortium include 11,765 participants (12,385 cases CKD)...
Background Cognitive impairments are associated with increased risk for progression to dementia. In China, limited surveys have been conducted estimate the national prevalence and factors cognitive impairment in China. This study aims assess modifiable Chinese elderly population. Methods cross-sectional was based on 2018 China Health Retirement Longitudinal Study. The Mini Mental State Examination (MMSE) is recommended test impairment. Univariate multivariate logistic regression models were...
Abstract Bladder outlet obstruction (BOO) is a prevalent condition arising from urethral stricture, posterior valves, and benign prostatic hyperplasia. Long‐term can lead to bladder remodeling, which characterized by inflammatory cell infiltration, detrusor hypertrophy, fibrosis. Until now, there are no efficacious therapeutic options for BOO‐induced remodeling. Tetrahedral framework nucleic acids (tFNAs) type of novel 3D DNA nanomaterials that possess excellent antifibrotic effects. Here,...
Abstract Background and purpose The causal association between inflammatory cytokines the development of intracranial aneurysm (IA), unruptured IA (uIA) subarachnoid hemorrhage (SAH) lacks clarity. Methods summary‐level datasets for were extracted from a genome‐wide study Finnish Cardiovascular Risk in Young Adults Study FINRISK survey. summary statistics related to IA, uIA SAH obtained meta‐analysis International Stroke Genetics Consortium FinnGen Consortium. primary method employed...
Young men who have sex with (YMSM) represent one of the most at-risk groups for HIV infection and experience sexual minority stress especially in high-stigma settings, which affects their psychological health increases likelihood HIV-risk behaviors. The epidemic China is increasing rapidly among YMSM. However, no evidence-based intervention has specifically targeted Chinese YMSM's to improve mental health. Adaptation interventions promote YMSM promising way achieve global target control....
Background: To investigate the association between lower urinary tract symptoms suggestive of benign prostate hyperplasia (LUTS/BPH) and metabolic syndrome (MetS) in aging Chinese males. Methods: A dataset that included 3,568 non-MetS cases 1,020 MetS (after data cleansing) was downloaded from China Health Retirement Longitudinal Study (CHARLS). balance intergroup covariates, propensity score matching (PSM) employed analyses. Univariate logistic regression multivariate were then performed to...
Sleep has attracted extensive attention due to its significance in health. However, association with erectile dysfunction (ED) is insufficiently investigated. To investigate the potential causal links between sleep traits (insomnia, duration, and chronotype) ED, this study was performed. The single-nucleotide polymorphisms (SNPs) associated insomnia, chronotype were retrieved from previous genome-wide studies (GWAS). A conventional two-sample Mendelian randomization (MR) used estimate ED....
The role of metabolic syndrome (MetS) on stroke has been explored only in many observational studies. We conducted Mendelian randomization (MR) to clarify whether or not the genetically predicted MetS and its components are causally associated with subtypes. Genetic instruments outcome data sets for subtypes came from gene-wide association study UK Biobank MEGASTROKE consortium, respectively. Inverse variance weighting was utilized as main method. Genetically MetS, waist circumference (WC),...
aDepartment of Urology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China bDepartment Institute West Sichuan Chengdu, Sichuan, Fuxun Zhang and Yang Xiong contributed equally to this work. Sponsorships or competing interests that may be relevant content are disclosed at the end article. *Corresponding author. Address: Department China. E-mail address: [email protected] (B. Zhang). Supplemental Digital Content is available for Direct URL citations provided in HTML PDF...
Introduction Circadian syndrome (CircS) is proposed as a novel risk cluster based on reduced sleep duration, abdominal obesity, depression, hypertension, dyslipidemia and hyperglycemia. However, the association between CircS chronic kidney disease (CKD) remains unclear. To investigate cross-sectional longitudinal CKD, this study was performed. Methods A national prospective cohort (China Health Retirement Longitudinal Study, CHARLS) used in study. define estimated glomerular filtration rate...
ABSTRACT Twenty-three isolates of group A streptococci (GAS) recovered from population-based invasive GAS surveillance in the United States were erythromycin resistant, inducibly clindamycin and lacked known macrolide resistance determinants. These 23 isolates, representing four different clones, contained a broad-host-range plasmid carrying erm (T) methylase gene, which has not been detected previously.
Background The association between the instrumental activities of daily living (IADL) score and risk initial cognitive function impairment is inconclusive. We aimed to identify distinctive IADL trajectories examine their relationship with onset mild (MCI) among Chinese older people. Methods study used six-wave longitudinal data from Longitudinal Healthy Longevity Survey conducted 2002 2018. It included a total 11,044 people aged 65 years or older. A group-based trajectory model was score,...
Abstract HIV prevalence among Chinese men who have sex with has rapidly increased in recent years. In this randomized, controlled study, we tested the feasibility and efficacy of motivational interviewing to reduce high‐risk sexual behaviors population Changsha, China. Eighty were randomly assigned either intervention group, which participants received a three‐session over 4 weeks, or control usual counseling from peer educators. High‐risk behavior indicators knowledge level evaluated at...
Smartphone use disorder (SUD) of college students has drawn increasing attention. Although future time perspective (FTP) may be an important protective factor for individual SUD, the moderating and mediating mechanisms underlying this relationship remain unknown. We tested roles depression mindfulness as moderators relationship.A cross-sectional study was conducted in two colleges Shandong Chongqing China using a sample 1304 recruited by stratified cluster sampling. Data were collected...
Background The association between snoring and erectile dysfunction (ED) is inconsistent in multiple observational studies. To clarify the causal of on ED, we performed this two-sample Mendelian randomization study. Materials Methods single nucleotide polymorphisms (SNPs) associated with were retrieved from UK biobank cohort 314,449 participants (117,812 cases 196,637 controls). summary statistics ED obtained European ancestry 223,805 subjects (6,175 217,630 Single-variable (MR)...