A5101644824- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Cerebrospinal fluid and hydrocephalus
- Hemoglobinopathies and Related Disorders
- MicroRNA in disease regulation
- Vascular Malformations Diagnosis and Treatment
- Circular RNAs in diseases
- Metabolism, Diabetes, and Cancer
- Spinal Hematomas and Complications
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- Peptidase Inhibition and Analysis
- T-cell and B-cell Immunology
- Peroxisome Proliferator-Activated Receptors
- CAR-T cell therapy research
First Affiliated Hospital of Xi'an Jiaotong University
2022-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Nanchang University
2022-2024
Sichuan University
2011-2024
West China Hospital of Sichuan University
2011-2024
Chinese PLA General Hospital
2023
First Affiliated Hospital of Nanchang University
2022-2023
Wuhan University
2019-2021
Xi'an Jiaotong University
2021
Model Animal Research Center
2021
Activation of the stimulator interferon gene (STING)-mediated innate immune response has been suggested as a promising therapeutic strategy for cancers. However, effects STING agonist on natural killer (NK) cell-mediated anti-tumor responses in pancreatic cancer remains unknown. Herein, we evaluated classical cyclic GMP-AMP (cGAMP) NK cells cancer. We found that cGAMP could directly activate and enhance sensitivity to cell cytotoxicity, suggesting may become potential adjuvant therapy. In...
The causal association between the gut microbiome and development of migraine its subtypes remains unclear.The single nucleotide polymorphisms concerning were retrieved from gene-wide study (GWAS) MiBioGen consortium. summary statistics datasets migraine, with aura (MA), without (MO) obtained GWAS meta-analysis International Headache Genetics Consortium (IHGC) FinnGen Inverse variance weighting (IVW) was used as primary method, complemented by sensitivity analyses for pleiotropy increasing...
Inflammation plays a role in secondary brain injury after intracerebral hemorrhage (ICH). We aimed to determine the prognostic significance of admission white blood cell (AWC), neutrophil count (ANC), lymphocyte count, monocyte and ratio (NLR) for 90-day outcome ICH. A total 336 patients with spontaneous ICH were retrospectively investigated. Clinical was assessed by modified Rankin Scale at 90 days. Multivariate analysis showed that higher AWC, ANC, NLR independently associated mortality...
Activation of apoptosis signal-regulating kinase 1 (ASK1) is a key driving force the progression nonalcoholic steatohepatitis (NASH) and represents an attractive therapeutic target for NASH treatment. However, molecular cellular mechanisms underlying ASK1 activation in pathogenesis remain incompletely understood. In this study, our data unequivocally indicated that hyperactivated hepatocytes potent inducer hepatic stellate cell (HSC) by promoting production hepatocyte-derived factors. Our...
IMA-1 targets the ALOX12-ACC1 interaction to both prevent and treat NASH without inducing hyperlipidemia.
Background and Aims Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic disease, which has no specific pharmacological treatments partially because of unclear pathophysiological mechanisms. Regulator G protein signaling (RGSs) proteins are that negatively regulate protein–coupled receptor (GPCR) signaling. The members R4/B subfamily smallest RGS in size, RGS5 belongs to this family, mediates pluripotent biological functions through canonical protein–mediated pathways...
Abstract Lactate dehydrogenase B (LDHB) reversibly catalyzes the conversion of pyruvate to lactate or and expressed in various malignancies. However, role LDHB modulating immune responses against hepatocellular carcinoma (HCC) remains largely unknown. Here, we found that down-regulation was coupled with promoter hypermethylation knocking down DNA methyltransferase 3A (DNMT 3A) restored expression levels HCC cell lines. Bioinformatics analysis cohort from The Cancer Genome Atlas revealed a...
ALOX12 drives NASH by inhibiting ACC1 lysosomal degradation across multiple species.
The cell-mediated protective and pathogenic immune responses to SARS-CoV-2 infection remain largely elusive. Here we identified 76 distinct cell subsets in the PBMC samples that were associated with various clinical presentations of COVID-19 using scRNA-seq technology coupled a deep comprehensive analysis unique surface markers differentially expressed genes. We revealed (TRAV1-2 + CD8 )MAIT cells (NCAM1 hi CD160 )NK significantly enriched asymptomatic subjects whereas (LAG3 )NKT increased...
Deubiquitinases (DUBs) play critical roles in tumorigenesis and are emerging as potential therapeutic targets. However, it remains less clear which DUBs may important represent a realistic vulnerability for particular type of tumor. Here we revealed that Ubiquitin Specific Peptidase 49 (USP49) is transcriptionally activated by c-MYC colorectal cancer (CRC), CRC patients with elevated USP49 levels exhibited significantly shorter survival. Knockdown markedly inhibited cell proliferation,...
Abstract Background Gastric cancer is a highly prevalent type and the underlying molecular mechanisms are not fully understood. Ubiquitin-specific peptidase (USP) 29 has been suggested to regulate cell fate in several types of cancer, but its potential role gastric carcinogenesis remains unclear. Methods The expression USP29 normal tissues was analyzed by bioinformatics analysis, immunohistochemistry immunoblot. Gene overexpression, CRISPR-Cas9 technology, RNAi, Usp29 knockout mice were used...
Abstract Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), an emerging immune checkpoint molecule, exhibits therapeutic potential in acute myeloid leukemia (AML). While single nucleotide polymorphisms (SNPs) of genes have been extensively investigated AML, the association between LILRB4 genetic and clinical outcomes remains unexplored. We SNPs within immunoglobulin domain immunoreceptor tyrosine-based inhibitory motif (ITIM) regions 151 AML patients 203 controls. The...
Studies on antihypertensive treatment for surgical patients with spontaneous intracerebral hemorrhage are insufficient. This pilot study was conducted to investigate the safety of perioperative intensive blood pressure lowering in hemorrhage.This a prospective, parallel, randomized, assessor-blinded trial. Patients allocated group received aiming achieve target systolic between 120 and 140 mm Hg, whereas conservative 180 Hg 7 days. The primary outcome rate rehemorrhage at days after...
MicroRNAs (miRNAs) have been shown to play important roles in viral infections, but their associations with SARS-CoV-2 infection remain poorly understood. Here, we detected 85 differentially expressed miRNAs (DE-miRNAs) from 2,336 known and 361 novel that were identified 233 plasma samples 61 healthy controls 116 patients COVID-19 using the high-throughput sequencing computational analysis. These DE-miRNAs associated SASR-CoV-2 infection, disease severity, persistence COVID-19, respectively....
Serum lipid levels are associated with the risk of intracerebral hemorrhage (ICH). Genetic variants in apolipoprotein C3 (APOC3) gene were plasma triglyceride (TG) and very-low-density lipoprotein (VLDL) levels. The aim this study was to evaluate effect two genetic (1100 C/T 3238 C/G) APOC3 on serum ICH.A prospective hospital-based case-control design logistic regression analysis utilized. We enrolled 150 ICH patients age- gender-matched controls. polymorphisms determined by polymerase chain...
SARS-CoV-2 evolves constantly with various novel mutations. Due to their enhanced infectivity, transmissibility and immune evasion, a comprehensive understanding of the association between these mutations respective functional changes is crucial. However, previous mutation studies major variants remain limited. Here, we performed systematic analyses full-length amino acids mutation, phylogenetic features, protein physicochemical properties, molecular dynamics escape as well pseudotype virus...
Clear cell renal carcinoma (ccRCC) is characterized by Von Hippel Lindau (VHL) gene loss of function mutation, which leads to the accumulation hypoxia-inducible factor 2α (HIF2α). HIF2α has been well-established as one major oncogenic drivers ccRCC, however, its therapeutic targeting remains a challenge. Through an analysis proteomic data from ccRCCs and adjacent non-tumor tissues, we herein revealed that Ubiquitin-Specific Peptidase 7 (USP7) was upregulated in tumor depletion inhibitors or...