A5100750686- Immune Response and Inflammation
- Parasitic Diseases Research and Treatment
- Studies on Chitinases and Chitosanases
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Oral microbiology and periodontitis research
- Autophagy in Disease and Therapy
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Botulinum Toxin and Related Neurological Disorders
- Immunotherapy and Immune Responses
- Gout, Hyperuricemia, Uric Acid
- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Digital Media Forensic Detection
- Stroke Rehabilitation and Recovery
- Peptidase Inhibition and Analysis
- Chaos-based Image/Signal Encryption
- Cholesterol and Lipid Metabolism
- Galectins and Cancer Biology
- Insect symbiosis and bacterial influences
- Biochemical effects in animals
- Hormonal Regulation and Hypertension
Beijing University of Posts and Telecommunications
2021-2025
Inner Mongolia Agricultural University
2025
State Grid Corporation of China (China)
2025
Hunan Institute of Engineering
2016-2024
First Affiliated Hospital of Xi'an Jiaotong University
2023-2024
Beijing Children’s Hospital
2023-2024
Second Hospital of Anhui Medical University
2020-2024
Anhui Medical University
2020-2024
Zhengzhou University
2022-2024
Capital Medical University
2013-2024
Mitochondria are critical cellular energy resources and central to the life of neuron. Mitophagy selectively clears damaged or dysfunctional mitochondria through autophagic machinery maintain mitochondrial quality control homeostasis. Mature neurons postmitotic consume substantial energy, thus require highly efficient mitophagy pathways turn over mitochondria. Recent evidence indicates that is pivotal pathogenesis neurological diseases. However, more work needed study pathway components as...
Palliative care (PC) can improve the quality of life Parkinson's disease (PD) patients and their carers. However, impact PC services on with PD remains unclear. This research was conducted to identify barriers facilitators influencing for based Social Ecological Model (SEM) framework.This through semi-structured interviews, employing SEM organize themes potential solutions across multiple levels.A total 29 interviewees (5 clinicians, 7 registered nurses, 8 patients, 5 caregivers, 4 policy...
Abstract Chemokines secreted by dendritic cells (DCs) play a key role in the regulation of inflammation and autoimmunity through chemokine receptors. However, receptor CXCR1 inflammation-inducing experimental autoimmune encephalomyelitis (EAE) acute respiratory distress syndrome (ARDS) remains largely enigmatic. Here we reported that compared with healthy controls, level was aberrantly increased multiple sclerosis (MS) patients. Knockout not only ameliorated disease severity EAE mice but...
Despite the importance of WRKY genes in plant physiological processes, little is known about their roles Panax ginseng C.A. Meyer. Forty-eight unigenes on this species were previously reported as transcripts using next-generation sequencing (NGS) technology. Subsequently, one gene that encodes PgWRKY1 protein belonging to subgroup II-d was cloned and functionally characterized. In study, eight from NGS-based transcriptome dataset designated PgWRKY2-9 have been The encoding proteins assigned...
Abstract Background Gastric cancer is a highly prevalent type and the underlying molecular mechanisms are not fully understood. Ubiquitin-specific peptidase (USP) 29 has been suggested to regulate cell fate in several types of cancer, but its potential role gastric carcinogenesis remains unclear. Methods The expression USP29 normal tissues was analyzed by bioinformatics analysis, immunohistochemistry immunoblot. Gene overexpression, CRISPR-Cas9 technology, RNAi, Usp29 knockout mice were used...
Previous studies have shown that recombinant Trichinella spiralis galectin (rTsgal) is characterized by a carbohydrate recognition domain sequence motif binding to beta-galactoside, and rTsgal promotes larval invasion of intestinal epithelial cells. Galactomannan an immunostimulatory polysaccharide composed mannan backbone with galactose residues. The aim this study was investigate whether galactomannan inhibits intrusion cells enhances antibody-dependent cellular cytotoxicity (ADCC),...
Pyruvate kinase widely exists in many parasites and plays an important role the energy production for parasites. might be a potential drug target killing The aim of present study was to evaluate biological characteristics roles T. spiralis pyruvate M (TsPKM) sugar metabolism, larval molting development spiralis. TsPKM has two functional domains tertiary structure is tetramer which enzyme active site constituted by 8 amino-acid residues (Arg71, Asn73, Asp110, Phe241, Lys267, Glu269, Asp293...
Streptococcus mutans (S. mutans) effectively utilizes dietary sucrose for the exopolysaccharide productions, which are mostly synthesized by effects of glucosyltransferases (Gtfs). In present study, acetylome S. was identified and quantitative analysis bacterial biofilm growth (SMB) compared with that planktonic (SMP). The dynamic changes protein acetylation were quantified using integrated approach involving TMT labeling Kac affinity enrichment followed high-resolution mass...
Trichinella spiralis dipeptidyl peptidase 1 (TsDPP1), or cysteine cathepsin C, is a secretory protein that highly expressed during the infective larvae and adult worm stages in intestines. The aim of this study was to investigate mechanism by which recombinant TsDPP1 (rTsDPP1) activates macrophages M2 polarization decreases macrophage cytotoxicity kill newborn via ADCC. RAW264.7 murine peritoneal were used study. results immunofluorescence test (IFT) confocal microscopy showed rTsDPP1...
Prostaglandin F2α (PGF2α) and thromboxane A2 (TXA2) are endogenous arachidonic acid metabolites, modulating diverse physiological processes including inflammation cardiovascular homeostasis through activating PGF2α receptor (FP) TXA2 (TP). Ligands targeting FP TP have demonstrated efficacy in treating conditions like glaucoma diseases humans, as well reproductive-related animals. Here, we present five cryoelectron microscopy structures illustrating complex with Gq bound to (endogenous...
Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated innate immune responses. However, the Tollip gene has not been systematically characterized in shellfish. In this study, we identified and gene, PyTollip, Yesso scallop (Patinopecten yessoensis). Phylogenetic structural analyses were conducted to determine its sequence identities evolutionary relationships. Compared with genes from other invertebrate vertebrate species, PyTollip highly conserved...
Abstract Background Sepsis is a troublesome syndrome that can cause intestinal injury and even high mortality rates. Omega-3 fatty acids (FAs) are known to protect against damage. Accordingly, the current study set out explore if omega-3 FAs could affect sepsis-induced with involvement of microRNA (miR)-1-3p/Notch3-Smad axis. Methods First, cecal ligation perforation (CLP) was performed establish septic mouse models in C57BL/6J mice, epithelial MODE-K cells were induced by lipopolysaccharide...
Dietary intake of cereal fiber has been reported to benefit lipid metabolism through multiple mechanisms. The present study aimed discover the potential mechanisms by which could modify intestinal cholesterol metabolism.Male C57BL/6 mice were fed a reference chow (RC) diet; high-fat, high-cholesterol (HFC) HFC plus oat or wheat bran diet for 24 weeks. Serum lipids measured enzymatic methods. Western blot was used determine protein expressions involved in metabolism.Our results showed that...