A5088935892- Nuclear Materials and Properties
- Functional Brain Connectivity Studies
- Nuclear reactor physics and engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural dynamics and brain function
- CRISPR and Genetic Engineering
- Autism Spectrum Disorder Research
- Parkinson's Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Fusion materials and technologies
- Cancer-related molecular mechanisms research
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Soybean genetics and cultivation
- Nuclear Engineering Thermal-Hydraulics
- Microstructure and mechanical properties
- Bioinformatics and Genomic Networks
- Aluminum Alloy Microstructure Properties
- Neurological Disease Mechanisms and Treatments
- Single-cell and spatial transcriptomics
- Mental Health Research Topics
- Neurological disorders and treatments
- Nuclear and radioactivity studies
- Aerodynamics and Fluid Dynamics Research
Hefei University
2025
Xi'an Jiaotong University
2018-2025
Yunnan University
2022-2025
National Chiayi University
2024-2025
China People's Public Security University
2023-2024
University of Chinese Academy of Sciences
2014-2024
Jiangsu Academy of Agricultural Sciences
2022-2024
Center for Excellence in Brain Science and Intelligence Technology
2020-2024
Guangdong Medical College
2024
Chinese Academy of Sciences
2014-2023
Recent studies have demonstrated that formaldehyde (FA) - induced neurotoxicity is important in the pathogenesis of Alzheimer's disease (AD). Elevated levels FA been associated with memory impairments and main hallmarks AD pathology, including β-amyloid plaques, tau protein hyperphosphorylation neuronal loss. Resveratrol (Res), as a polyphenol anti-oxidant, has considered to therapeutic potential for treatment AD. However, it not elucidated whether Res can exert its neuroprotective effects...
Schizophrenia is a disorder characterized by functional dysconnectivity among distributed brain regions. However, it unclear how causal influences large-scale networks are disrupted in schizophrenia. In this study, we used dynamic modeling (DCM) to assess the hypothesis that there aberrant directed (effective) connectivity within and between three key (the dorsal attention network, salience network default mode network) schizophrenia during working memory task. Functional MRI data an n-back...
Mitochondria are critical cellular energy resources and central to the life of neuron. Mitophagy selectively clears damaged or dysfunctional mitochondria through autophagic machinery maintain mitochondrial quality control homeostasis. Mature neurons postmitotic consume substantial energy, thus require highly efficient mitophagy pathways turn over mitochondria. Recent evidence indicates that is pivotal pathogenesis neurological diseases. However, more work needed study pathway components as...
In this study, we investigated auditory-visual stimulation-induced P300 and examined whether was differentially modulated between individuals with clinical depression healthy controls. We hypothesized that the component would significantly differ Specifically, predicted induced by bimodal oddball task be different from unimodal task. Forty-five forty-five controls participated in study. All participants were instructed to complete three tasks—auditory (A), visual (V), (AV)—while their...
Abstract Whether direct manipulation of Parkinson’s disease (PD) risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved issue. Here, we used adeno-associated virus serotype 9 (AAV9)-delivered CRISPR/Cas9 system to directly co-edit PINK1 and DJ-1 substantia nigras (SNs) two groups: old group middle-aged group. After operation, exhibited all classic PD symptoms, including bradykinesia, tremor, postural instability, accompanied by key pathological hallmarks...
To better understand the application of IVR (In-Vessel Retention), extensive experiments have been conducted on heat transfer characteristics molten pool. However, most research mainly focuses hemispherical lower heads, and ellipsoidal head suitable for small pressurized water reactors is relatively lacking. In order to provide some reference implementation with head, this paper experimental study a three-dimensional double-layer pool based design reactor. The test section consists two...
The addition reactions of propylene with singly bonded G13/P‐based (G13 = Group 13 element) and B/G15‐based (G15 15 molecules, all yielding the >G13–G15< geometrical structure, have been analyzed theoretically using density functional theory (DFT). current DFT findings indicate that, Al/G15‐based only Al/P‐Rea can reversibly carry out [2 + 2] reaction propylene, both from kinetic thermodynamic viewpoints. activation strain model suggests that deformation energy fragment is pivotal in...
A recently established link between formaldehyde, a methanol metabolite, and Alzheimer's disease (AD) pathology has provided new impetus to investigate the chronic effects of exposure. This paper expands this investigation non-human primate, rhesus macaque, through feeding young male monkeys with 3% ad libitum. Variable Spatial Delay Response Tasks found that led persistent memory decline in lasted 6 months beyond regimen. change coincided increases tau protein phosphorylation at residues...
To decipher the organizational logic of complex brain circuits, it is important to chart long-distance pathways while preserving micron-level accuracy local network. However, mapping neuronal projections with individual-axon resolution in large and primate still challenging. Herein, we describe a highly efficient pipeline for three-dimensional entire macaque subcellular resolution. The includes novel poly-N-acryloyl glycinamide (PNAGA)-based embedding method long-term structure fluorescence...
Background: Dysconnectivity hypothesis of schizophrenia has been increasingly emphasized. Recent researches showed that this dysconnectivity might be related to occurrence auditory hallucination (AH). However, there is still no consistent conclusion. This study aimed explore intrinsic pattern whole-brain functional networks at voxel level in schizophrenic with AH. Methods: Auditory hallucinated patients group (n = 42 APG), NPG) and normal controls 84 NCs) were analyzed by resting-state...
Brain aging is a complex process that depends on the precise regulation of multiple brain regions; however, underlying molecular mechanisms behind this remain to be clarified in non-human primates.Here, we explore primate using 547 transcriptomes originating from 44 areas rhesus macaques (Macaca mulatta). We show expression connectivity between pairs cerebral cortex as well symmetry left and right hemispheres both decrease after aging. Although across different are largely convergent,...