A5075328167- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Single-cell and spatial transcriptomics
- Primate Behavior and Ecology
- Bioinformatics and Genomic Networks
- Chromosomal and Genetic Variations
- HIV Research and Treatment
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Genomic variations and chromosomal abnormalities
- RNA Research and Splicing
- Respiratory viral infections research
- Bat Biology and Ecology Studies
- Genetics, Bioinformatics, and Biomedical Research
- Animal Nutrition and Physiology
- Livestock and Poultry Management
- CRISPR and Genetic Engineering
- Influenza Virus Research Studies
- Amphibian and Reptile Biology
- Gene expression and cancer classification
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Behavior and Reproduction
- Genomics and Rare Diseases
- Marine Ecology and Invasive Species
Suihua University
2025
Chinese Academy of Sciences
2015-2025
Kunming Institute of Zoology
2015-2025
Shandong Yingcai University
2025
Minzu University of China
2025
Kunming University
2024
Beijing Radiation Center
2019
Central South University
2007
Shanghai Jian Qiao University
2003
The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact genomic on fundamental biological processes. Analysis that insight into long-standing questions evolutionary conservation biology is urgent given severe threats these are facing. Here, we present high-coverage whole-genome data from 233 representing 86% genera all 16 families. This dataset was used, together with fossil calibration, create a nuclear DNA...
Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding their clinical relevance remains largely incomplete. To systematically decipher the effects human variants, we obtained whole-genome data for 809 individuals from 233 primate species and identified 4.3 million common protein-altering variants with orthologs in humans. We show that these can be inferred to have nondeleterious humans based on presence at high allele...
Comparative analysis of primate genomes within a phylogenetic context is essential for understanding the evolution human genetic architecture and diversity. We present such study 50 species spanning 38 genera 14 families, including 27 first reported here, with many from previously less well represented groups, New World monkeys Strepsirrhini. Our analyses reveal heterogeneous rates genomic rearrangement gene across lineages. Thousands genes under positive selection in different lineages play...
Due to the small and irregular shapes of vegetable seeds, modeling them is challenging, imprecision physical parameters hinders performance seeders, impeding simulation development. In this study, seeds cucumber, pepper, tomato were seen as examples. A 3D point cloud reconstruction method based on Structure-from-Motion Multi-View Stereo (SfM-MVS) was employed accurately extract models irregularly shaped seeds. Corresponding discrete element established. Combining experiments seed angle...
Abstract The earthworm is particularly fascinating to biologists because of its strong regenerative capacity. However, many aspects regeneration in nature remain elusive. Here we report chromosome-level genome, large-scale transcriptome and single-cell RNA-sequencing data during ( Eisenia andrei ) regeneration. We observe expansion LINE2 transposable elements gene families functionally related (for example, EGFR , epidermal growth factor receptor) for genes exhibiting differential expression...
Incomplete lineage sorting (ILS) causes the phylogeny of some parts genome to differ from species tree. In this work, we investigate frequencies and determinants ILS in 29 major ancestral nodes across entire primate phylogeny. We find up 64% affected by at individual nodes. exploit reconstruct speciation times population sizes. Estimated are much more recent than genomic divergence good agreement with fossil record. show extensive variation along genome, mainly driven recombination but also...
Abstract Noncoding DNA is central to our understanding of human gene regulation and complex diseases 1,2 , measuring the evolutionary sequence constraint can establish functional relevance putative regulatory elements in genome 3–9 . Identifying genomic that have become constrained specifically primates has been hampered by faster evolution noncoding compared protein-coding 10 relatively short timescales separating primate species 11 previously limited availability whole-genome sequences 12...
Although species can arise through hybridization, compelling evidence for hybrid speciation has been reported only rarely in animals. Here, we present phylogenomic analyses on genomes from 12 macaque and show that the fascicularis group originated an ancient hybridization between sinica silenus groups ~3.45 to 3.56 million years ago. The X chromosomes low-recombination regions exhibited equal contributions each parental lineage, suggesting they were less affected by subsequent backcrossing...
Significance Central topics in evolutionary biology include uncovering the processes and genetic bases of speciation documenting environmental adaptations responsible for them. The challenging environment Qinghai-Tibetan Plateau (QTP) facilitates such investigations, Tibetan frog, Nanorana parkeri , offers a unique opportunity to investigate these processes. A cohort whole-genome sequences 63 individuals from across its entire range opens avenues incorporating population genomics into...
Abstract The plateau zokor (Myospalax baileyi) spends its entire life underground in sealed burrows. Confronting limited oxygen and high carbon dioxide concentrations complete darkness, they epitomize a successful physiological adaptation. Here, we employ transcriptome sequencing to explore the genetic underpinnings of their adaptations this unique habitat. Compared Rattus norvegicus , genes belonging GO categories related energy metabolism (e.g. mitochondrion fatty acid beta-oxidation)...
Abstract In mammalian societies, dominance hierarchies translate into inequalities in health, reproductive performance and survival. DNA methylation is thought to mediate the effects of social status on gene expression phenotypic outcomes, yet a study status-specific profiles different age classes wild mammal missing. We tested for signatures female spotted hyenas ( Crocuta crocuta ), cubs adults, using non-invasively collected gut epithelium samples. hyena clans, influences access...
Northeast China (NEC) is a major spring maize (Zea mays L.) growing belt, and the outputs substantially influence national grain production. However, yield per unit area has little changes in recent years, partially due to lack of elite germplasm resources innovation. Therefore, this study aimed determine performance diverse populations NEC propose appropriate strategies for utilization broaden genetic base Chinese germplasm. Fifteen from International Maize Wheat Improvement Center (CIMMYT)...
ABSTRACT Aims Developing validated treatments for Parkinson's disease (PD) remains a priority clinicians and researchers. The lack of viable therapies may stem from an incomplete understanding PD pathogenesis inadequate therapeutic candidates. production transmission exosomes are gaining recognition in the neurodegenerative diseases. However, how affect pathophysiology has not been well elucidated. Methods Here, we investigated effect secreted by rats that were treated with saline or...
Abstract Introduction: CRISPR screens have been successfully used to identify targetable genes for anti-cancer research and drug development. Typically, are conducted in vitro on cell lines, which do not fully capture the influence of vivo physiological environment. It is well known that any genetic editing might trigger adjustment gene balance compensate modifications target cells tissues. To address complexity cellular interactions immunological response, screening a xenograft model...
Abstract The homing pigeon was selectively bred from the domestic for a ability over long distances, very fascinating but complex behavioral trait. Here, we generate total of 95 whole genomes diverse breeds. Comparing population with those other breeds identifies candidate positively selected genes, including many genes involved in central nervous system, particularly spatial learning and memory such as LRP8. Expression profiling reveals neuronal displaying differential expression...
Brain aging is a complex process that depends on the precise regulation of multiple brain regions; however, underlying molecular mechanisms behind this remain to be clarified in non-human primates.Here, we explore primate using 547 transcriptomes originating from 44 areas rhesus macaques (Macaca mulatta). We show expression connectivity between pairs cerebral cortex as well symmetry left and right hemispheres both decrease after aging. Although across different are largely convergent,...
Abstract Although the continual expansion of brain during primate evolution accounts for our enhanced cognitive capabilities, drivers have scarcely been explored in these ancestral nodes. Here, we performed large-scale comparative genomic, transcriptomic, and epigenomic analyses to investigate evolutionary alterations acquired by genes provide comprehensive listings innovatory genetic elements along path from primates human. The regulatory sequences associated with brain-expressed...
Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding their clinical relevance remains largely incomplete. To systematically decipher the effects human variants, we obtained whole data for 809 individuals from 233 primate species, and identified 4.3 million common protein-altering variants with orthologs in human. We show that these can be inferred to have non-deleterious based on presence at high allele frequencies other...
Influenza A viruses evolve at a high rate of nucleotide substitution, thereby requiring continuous monitoring to determine the efficacy vaccines and antiviral drugs. In current study, we performed whole-genome sequencing analyses 253 influenza A/H3N2 strains from Yunnan Province, China, during 2017–2022. The hemagglutinin (HA) segments isolated 2017–2018 harbored genetic diversity due heterogeneous distribution across branches. mutation regularity predominant antigenic epitopes HA in was...
The Fenghuangshan Cu-Fe-Au deposit is located in Tongling, Anhui province central-east China, within the Middle-Lower Yangtze River polymetallic belt. mineralization related to Late Yanshanian magmatic intrusions emplaced Lower Triassic limestones and divided into two episodes. first more important, episode A, granodiorite-granodiorite porphyry characterized by massive, disseminated, veinlet- breccia-style skarn formed at contact zone, whereas second, B, a quartz monzodiorite stock which...
Guenons (tribe Cercopithecini) are the most widely distributed nonhuman primate in tropical forest belt of Africa and show considerable phenotypic, taxonomic, ecological diversity. However, genomic information for species within this group is still lacking. Here, we present a high-quality de novo genome (total 2.90 Gb, contig N50 equal to 22.7 Mb) mona monkey (Cercopithecus mona), together with resequencing data 13 individuals sampled across Nigeria. Our results showed differentiation...
The continuous variation of the seasonal influenza viruses, particularly A(H1N1)pdm09, persistently threatens human life and health around world. In local areas southwest china, large time-scale genomic research on A(H1N1)pdm09 is still insufficient. Here, we sequenced 45 whole-genome sequences viruses in Lincang, China, from 2014 to 2018, by next-generation sequencing technology characterize molecular mechanisms their origin evolution. Our phylogenetic analyses suggest that strains...
Lorises are a group of globally threatened strepsirrhine primates that exhibit many unusual physiological and behavioral features, including low metabolic rate, slow movement, hibernation. Here, we assembled chromosome-level genome sequence the pygmy loris ( Xanthonycticebus pygmaeus ) resequenced whole genomes from 50 lorises 6 Bengal Nycticebus bengalensis ). We found gene families involved in detoxification have been specifically expanded loris, GSTA family, with newly derived copies...