Mihir Trivedi
A5004389772- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- Primate Behavior and Ecology
- Livestock and Poultry Management
- Genomic variations and chromosomal abnormalities
- Bird parasitology and diseases
- Wildlife Ecology and Conservation
- Genomics and Rare Diseases
- Vector-borne infectious diseases
- Species Distribution and Climate Change
- Bat Biology and Ecology Studies
- Mosquito-borne diseases and control
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Vector-Borne Animal Diseases
- Virology and Viral Diseases
- Evolution and Paleontology Studies
- Viral Infections and Vectors
- RNA and protein synthesis mechanisms
- Amphibian and Reptile Biology
- Livestock Management and Performance Improvement
- CRISPR and Genetic Engineering
Centre for Cellular and Molecular Biology
2021-2025
University of Washington
2024
Howard Hughes Medical Institute
2024
The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact genomic on fundamental biological processes. Analysis that insight into long-standing questions evolutionary conservation biology is urgent given severe threats these are facing. Here, we present high-coverage whole-genome data from 233 representing 86% genera all 16 families. This dataset was used, together with fossil calibration, create a nuclear DNA...
Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding their clinical relevance remains largely incomplete. To systematically decipher the effects human variants, we obtained whole-genome data for 809 individuals from 233 primate species and identified 4.3 million common protein-altering variants with orthologs in humans. We show that these can be inferred to have nondeleterious humans based on presence at high allele...
Abstract Noncoding DNA is central to our understanding of human gene regulation and complex diseases 1,2 , measuring the evolutionary sequence constraint can establish functional relevance putative regulatory elements in genome 3–9 . Identifying genomic that have become constrained specifically primates has been hampered by faster evolution noncoding compared protein-coding 10 relatively short timescales separating primate species 11 previously limited availability whole-genome sequences 12...
We present haplotype-resolved reference genomes and comparative analyses of six ape species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran siamang. achieve chromosome-level contiguity with unparalleled sequence accuracy (<1 error in 500,000 base pairs), completely sequencing 215 gapless chromosomes telomere-to-telomere. resolve challenging regions, such as the major histocompatibility complex immunoglobulin loci, providing more in-depth evolutionary insights. Comparative...
ABSTRACT Past climate change is one of the important factors influencing primate speciation. Populations various species could have risen or declined in response to these climatic fluctuations. Northeast India harbors a rich diversity primates, where such fluctuations can be implicated. Recent advances modeling as well genomic data analysis has paved way for understanding how accumulate at particular geographic region. We utilized methods explore this unique region relation past change. To...
Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding their clinical relevance remains largely incomplete. To systematically decipher the effects human variants, we obtained whole data for 809 individuals from 233 primate species, and identified 4.3 million common protein-altering variants with orthologs in human. We show that these can be inferred to have non-deleterious based on presence at high allele frequencies other...
Abstract The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact genomic on fundamental biological processes. Analysis that insight into long-standing questions evolutionary conservation biology, is urgent given severe threats these are facing. Here, we present high coverage whole-genome data from 233 representing 86% genera all 16 families. This dataset was used, together with fossil calibration, create a...
Northeast India, with its variety of geographical features and topography, provides a plethora niches for species to evolve thrive. Among multitude factors, past climate change is one the important factors influencing primate speciation in this region. Populations various could have risen or declined response these climatic fluctuations. Recent advances modelling as well genomic data analysis has paved way understanding how accumulate at particular geographic We utilized methods explore...
Abstract The haematophagous nature of mallophagan species enables them to cause direct harm the vitality and productivity their hosts also allows act as reservoire pathogens. Menacanthus cornutus Schomm. has been recorded from Indian poultry birds, for first time. microscopic examination gut contents 1621 lice indicates its nature. presence host blood observed in 97.41% adult males, 99.11% females 63.33, 70 70.40% first, second third instar nymph, respectively. Zusammenfassung Aufdeckung der...
Abstract Objectives To ascertain the effect of historical demography and past climate change as drivers diversity in northeast India. Materials methods We took variant called whole genome files nine species present India from Primate sequencing consortium work assessed each historic effective population size by using Multiple Sequentially Markovian Coalescent (MSMC) tool. also constructed distribution models on (Pliocene Pleistocene) with Maxent, utilizing publicly available data for...