A5041332430- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Pluripotent Stem Cells Research
- RNA modifications and cancer
- Axon Guidance and Neuronal Signaling
- CRISPR and Genetic Engineering
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- Dermatology and Skin Diseases
- Sepsis Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Mitochondrial Function and Pathology
- Cellular transport and secretion
- Cancer-related gene regulation
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- RNA and protein synthesis mechanisms
- Developmental Biology and Gene Regulation
- Pneumocystis jirovecii pneumonia detection and treatment
- Chromosomal and Genetic Variations
Southern Medical University
2019-2025
Institute of Crop Sciences
2025
Chinese Academy of Agricultural Sciences
2025
University of Toronto
2025
University of Utah Health Care
2025
University of Jinan
2025
Nanfang Hospital
2022-2025
Stanford University
2015-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Chromatin looping is key to gene regulation, yet no broadly applicable methods selectively modify chromatin loops have been described. We engineered a method for loop reorganization using CRISPR-dCas9 (CLOuD9) and reversibly establish loops. demonstrate the power of this technology modulate expression at targeted loci.
The WDR5 subunit of the MLL complex enforces active chromatin and can bind RNA; relationship between these two activities is unclear. Here we identify a RNA binding pocket on WDR5, discover mutant (F266A) that selectively abrogates without affecting assembly or catalytic activity. Complementation in ESCs shows F266A unable to accumulate chromatin, defective gene activation, maintenance histone H3 lysine 4 trimethylation, ESC self renewal. We family messenger lncRNAs interact with wild type...
Mitophagy is the process of selective mitochondrial degradation via autophagy, which has an important role in quality control. Very little known, however, about molecular mechanism mitophagy. A genome-wide yeast mutant screen for mitophagy-defective strains identified 32 mutants with a block mitophagy, addition to known autophagy-related (ATG) gene mutants. We further characterized one these mutants, ylr356wDelta that corresponds whose function not been identified. YLR356W mitophagy-specific...
Macroautophagy (hereafter referred to simply as autophagy) is a catabolic pathway that mediates the degradation of long-lived proteins and organelles in eukaryotic cells. The regulation mitochondrial through autophagy plays an essential role maintenance quality control this organelle. Compared with our understanding function mitochondria many aspects cellular metabolism such energy production dysfunctional cell death, little known regarding their especially how upstream signaling pathways...
Patient-specific iPSCs model endothelial dysfunction in lamin A and C–related dilated cardiomyopathy identify lovastatin as a therapy.
Abstract Noncoding DNA is central to our understanding of human gene regulation and complex diseases 1,2 , measuring the evolutionary sequence constraint can establish functional relevance putative regulatory elements in genome 3–9 . Identifying genomic that have become constrained specifically primates has been hampered by faster evolution noncoding compared protein-coding 10 relatively short timescales separating primate species 11 previously limited availability whole-genome sequences 12...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic that has no effective treatment. Our proprietary probiotic mixture, Prohep, been proven in previous study to be helpful reducing hepatocellular carcinoma (HCC) vivo. However, its prospective benefits on the treatment of other diseases such as MASLD, which one major risk factors development HCC, are unclear. To investigate potential Prohep modulating and progression we first explored effect...