A5041999258- Phytochemicals and Antioxidant Activities
- Tea Polyphenols and Effects
- Phytoestrogen effects and research
- Gut microbiota and health
- Food Quality and Safety Studies
- Metabolomics and Mass Spectrometry Studies
- Pomegranate: compositions and health benefits
- Analytical Chemistry and Chromatography
- Fermentation and Sensory Analysis
- Biochemical Analysis and Sensing Techniques
- Antioxidant Activity and Oxidative Stress
- Microbial Metabolism and Applications
- Ginkgo biloba and Cashew Applications
- Sesame and Sesamin Research
- Tryptophan and brain disorders
- Cancer-related molecular mechanisms research
- Plant biochemistry and biosynthesis
- Nutrition, Genetics, and Disease
- Algal biology and biofuel production
- Diet and metabolism studies
- Advanced Glycation End Products research
- Potato Plant Research
- Pharmacology and Obesity Treatment
- Plant-derived Lignans Synthesis and Bioactivity
- Protein Hydrolysis and Bioactive Peptides
Hong Kong Polytechnic University
2021-2025
Ocean University of China
2023-2025
Qingdao Institute of Bioenergy and Bioprocess Technology
2025
Hong Kong Eye Hospital
2022-2023
Rutgers, The State University of New Jersey
2017-2021
Rutgers Sexual and Reproductive Health and Rights
2019-2020
University of Hong Kong
2014-2018
Chinese University of Hong Kong
2016-2018
Hong Kong Baptist University
2012
Chronic stress disrupts immune homeostasis while gut microbiota-derived metabolites attenuate inflammation, thus promoting resilience to stress-induced and behavioral abnormalities. There are both peripheral brain region-specific maladaptations of the response chronic that produce interrelated mechanistic considerations required for design novel therapeutic strategies prevention psychological impairment. This study shows a combination probiotics polyphenol-rich prebiotics, synbiotic,...
In this study, the influence of lactic acid bacteria fermentation on antioxidant capacity, phenolic compounds and vitamins profile soymilk with different final pH values (pH 4.55, 4.15 3.85) was examined. Fermented (FSM) a 3.85 exhibited relatively higher capacity than samples terminated at 4.55 or 4.15, as shown from results Folin–Ciocalteu assay (57.3–63.8 mg GAE/100 mL FSM), DPPH-radical scavenging efficiency (30.0–36.5%) ferricyanide reducing power (1.13–1.58 AAE/100 FSM). Among all...
This study evaluated the protective effects of two rosemary components, rosmarinic acid (RA) and carnosic (CA), against hypoglycemia, hyperlipidemia, oxidative stress an imbalanced gut microbiota architecture in diabetic rats. Treatment with RA CA (30 mg kg-1) decreased levels fasting plasma glucose (23.7%, 15.6%), total cholesterol (30.4%, 14.1%) triglyceride (65.7%, 47.8%) at 15 weeks. also exhibited anti-oxidative anti-glycative effect by lowering formation malondialdehyde advanced...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic that has no effective treatment. Our proprietary probiotic mixture, Prohep, been proven in previous study to be helpful reducing hepatocellular carcinoma (HCC) vivo. However, its prospective benefits on the treatment of other diseases such as MASLD, which one major risk factors development HCC, are unclear. To investigate potential Prohep modulating and progression we first explored effect...
Zearalenone (ZEA), a secondary metabolite of Fusarium fungi found in cereal-based foods, promotes the growth colon, breast, and prostate cancer cells vitro. However, lack animal studies hinders deeper mechanistic understanding cancer-promoting effects ZEA. This study aimed to determine effect ZEA on colon progression its underlying mechanisms. Through integrative analyses transcriptomics, metabolomics, metagenomics, host phenotypes, we investigated impact 4-week intervention colorectal...
Sample pretreatment for mass spectrometry (MS)-based metabolomics and lipidomics is normally conducted independently with two sample aliquots separate matrix cleanup procedures, making the two-step process sample-intensive time-consuming. Herein, we introduce a high-throughput workflow integrated nontargeted leveraging enhanced removal (EMR)-lipid microelution 96-well plates. The EMR-lipid technique was innovatively employed to effectively isolate non-lipid small metabolites lipids in...
The gut microbiota's metabolome is composed of bioactive metabolites that confer disease resilience. Probiotics' therapeutic potential hinges on their altering ability; however, characterizing probiotics' metabolic activity remains a formidable task. In order to solve this problem, an artificial model the human gastrointestinal tract introduced coined ABIOME (A Bioreactor Imitation Microbiota Environment) and used predict probiotic formulations' hence with machine learning tools. modular yet...
Objectives Raspberry ketone (RK) is the primary aroma compound in red raspberries and a dietary supplement for weight loss. This work aims to 1) compare RK bioavailability male versus female, normal‐weight obese mice; 2) characterize metabolic pathways. Methods Study 1: C57BL/6J female mice fed low‐fat diet (LFD; 10% fat) receive single oral gavage dose of (200 mg kg −1 ). Blood, brain, white adipose tissue (WAT) are collected over 12 h. 2: Male LFD or high‐fat (45% 8 weeks before dosing....
This work is the first to determine breast milk levels of phenolic compounds, including characteristic microbial-derived metabolites, in an Asian population and explored their correlation with maternal dietary intake.