Peter Frandsen
A5090162712- Genetic diversity and population structure
- Wildlife Ecology and Conservation
- Primate Behavior and Ecology
- Genomics and Phylogenetic Studies
- Viral Infections and Outbreaks Research
- Genomic variations and chromosomal abnormalities
- Chromosomal and Genetic Variations
- Genetic and phenotypic traits in livestock
- Nuclear physics research studies
- Bat Biology and Ecology Studies
- Human-Animal Interaction Studies
- Nuclear Physics and Applications
- Genomics and Rare Diseases
- Zoonotic diseases and public health
- Advanced NMR Techniques and Applications
- Neurobiology and Insect Physiology Research
- Nutrition, Genetics, and Disease
- Ecology and biodiversity studies
- Cell Image Analysis Techniques
- Yersinia bacterium, plague, ectoparasites research
- Neuroendocrine regulation and behavior
- Virology and Viral Diseases
- Modular Robots and Swarm Intelligence
- Environmental DNA in Biodiversity Studies
- Evolution and Genetic Dynamics
University of Copenhagen
1986-2024
Copenhagen Zoo
2016-2024
Natural History Museum Aarhus
2013-2014
Instituto Gulbenkian de Ciência
2013-2014
University of California, Berkeley
2013-2014
Genomes in the mist The mountain gorilla is an iconic species that at high risk of extinction. Xue et al. have sequenced 13 gorillas from two different populations to probe their genetic diversity. genomes show large tracts homozygosity and loss highly deleterious variants, indicating population bottlenecks inbreeding. This diversity appears started over 20,000 years ago may been caused by changes climate human-associated effects. Science , this issue p. 242
Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born bonobos from 10 countries in Africa. found that chimpanzee population substructure makes genetic information good predictor geographic origin at country regional scales. Multiple lines evidence suggest gene flow occurred into ancestors central eastern between 200,000 550,000 years ago, probably with subsequent spread Nigeria-Cameroon...
The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact genomic on fundamental biological processes. Analysis that insight into long-standing questions evolutionary conservation biology is urgent given severe threats these are facing. Here, we present high-coverage whole-genome data from 233 representing 86% genera all 16 families. This dataset was used, together with fossil calibration, create a nuclear DNA...
Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding their clinical relevance remains largely incomplete. To systematically decipher the effects human variants, we obtained whole-genome data for 809 individuals from 233 primate species and identified 4.3 million common protein-altering variants with orthologs in humans. We show that these can be inferred to have nondeleterious humans based on presence at high allele...
Species delimitation is one of the most contested areas in modern biology, with widespread disagreement about almost every aspect definition and implementation "species" label. While this debate intellectually stimulating, it also has real implications for conservation, where its impacts on taxonomic inflation or inertia can mean that specific populations receive adequate conservation measures are ignored. Recently, rise next generation sequencing phylogenomics revolutionised phylogenetic...
Abstract Noncoding DNA is central to our understanding of human gene regulation and complex diseases 1,2 , measuring the evolutionary sequence constraint can establish functional relevance putative regulatory elements in genome 3–9 . Identifying genomic that have become constrained specifically primates has been hampered by faster evolution noncoding compared protein-coding 10 relatively short timescales separating primate species 11 previously limited availability whole-genome sequences 12...
Correspondence to be sent to: Department of Biology, University Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark;E-mail: rheller@bio.ku.dk, rathmuth@gmail.com.R. Heller and P. Frandsen contributed equally this article.Received 3 December 2012; reviews returned 7 January 2013; accepted 18 2013Associate Editor: Frank (Andy) Anderson
Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding their clinical relevance remains largely incomplete. To systematically decipher the effects human variants, we obtained whole data for 809 individuals from 233 primate species, and identified 4.3 million common protein-altering variants with orthologs in human. We show that these can be inferred to have non-deleterious based on presence at high allele frequencies other...
Abstract The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact genomic on fundamental biological processes. Analysis that insight into long-standing questions evolutionary conservation biology, is urgent given severe threats these are facing. Here, we present high coverage whole-genome data from 233 representing 86% genera all 16 families. This dataset was used, together with fossil calibration, create a...
With the emergence of analytical software for inference viral evolution, a number studies have focused on estimating important parameters such as substitution rate and time to most recent common ancestor (tMRCA) rapidly evolving viruses. Coupled with an increasing abundance sequence data sampled under widely different schemes, effort keep results consistent comparable is needed. This study emphasizes commonly disregarded problems in evolutionary rates when sampling unevenly distributed...
Abstract Background Numerous Ebola virus outbreaks have occurred in Equatorial Africa over the past decades. Besides human fatalities, gorillas and chimpanzees also succumbed to fatal virus. The 2004 outbreak at Odzala-Kokoua National Park (Republic of Congo) alone caused a severe decline resident western lowland gorilla ( Gorilla ) population, with 95% mortality rate. Here, we explore immediate genetic impact population. Results Associations survivorship were evaluated by utilizing DNA...
Abstract Western chimpanzees ( Pan troglodytes verus ) are Critically Endangered and Guinea is a key stronghold for this subspecies. However, also rich in minerals with some of the highest‐grade iron‐ore deposits world. Specifically, Nimba Mountains, home to western chimpanzees, one sites under consideration mining activities. To assess impact activities area, we used non‐invasive genetic sampling estimate chimpanzee population size, sex ratio, community composition, range boundaries on...
Summary Establishing the genetic and geographic structure of populations is fundamental both to understand their evolutionary past preserve future, especially for endangered species. Nevertheless, patterns population are unknown most species, including some our closest living relatives. This case bonobos ( Pan paniscus ) which together with chimpanzees troglodytes humans’ Chimpanzees live across equatorial Africa classified into four subspecies (Groves, 2001), substructure even within...