Claudia Fontsere
A5004218229- Primate Behavior and Ecology
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Genetic and phenotypic traits in livestock
- Wildlife Ecology and Conservation
- Lepidoptera: Biology and Taxonomy
- Plant and animal studies
- Animal Behavior and Reproduction
- Viral Infections and Outbreaks Research
- Epigenetics and DNA Methylation
- Forensic and Genetic Research
- Species Distribution and Climate Change
- Amino Acid Enzymes and Metabolism
- Genetic Mapping and Diversity in Plants and Animals
- Zoonotic diseases and public health
- Molecular Biology Techniques and Applications
- Chromosomal and Genetic Variations
- Metabolism and Genetic Disorders
- Pleistocene-Era Hominins and Archaeology
- Virology and Viral Diseases
- Yersinia bacterium, plague, ectoparasites research
- Drug Transport and Resistance Mechanisms
- Amphibian and Reptile Biology
- Fetal and Pediatric Neurological Disorders
- Identification and Quantification in Food
Institut de Biologia Evolutiva
2017-2025
University of Copenhagen
2022-2025
Universitat Pompeu Fabra
2017-2024
Evolutionary Genomics (United States)
2022-2024
Consejo Superior de Investigaciones Científicas
2019-2023
Barcelona Biomedical Research Park
2019-2023
How populations adapt to their environment is a fundamental question in biology. Yet, we know surprisingly little about this process, especially for endangered species, such as nonhuman great apes. Chimpanzees, our closest living relatives, are particularly notable because they inhabit diverse habitats, from rainforest woodland-savannah. Whether genetic adaptation facilitates habitat diversity remains unknown, despite it having wide implications evolutionary biology and conservation. By...
Baboons (genus Papio ) are a morphologically and behaviorally diverse clade of catarrhine monkeys that have experienced hybridization between phenotypically genetically distinct phylogenetic species. We used high-coverage whole-genome sequences from 225 wild baboons representing 19 geographic localities to investigate population genomics interspecies gene flow. Our analyses provide an expanded picture evolutionary reticulation among species reveal patterns structure within species, including...
Analyses of ancient DNA typically involve sequencing the surviving short oligonucleotides and aligning to genome assemblies from related, modern species. Here, we report that skin a female woolly mammoth (†Mammuthus primigenius) died 52,000 years ago retained its architecture. We use PaleoHi-C map chromatin contacts assemble genome, yielding 28 chromosome-length scaffolds. Chromosome territories, compartments, loops, Barr bodies, inactive X chromosome (Xi) superdomains persist. The active...
Ecological flexibility, extended lifespans, and large brains have long intrigued evolutionary biologists, comparative genomics offers an efficient effective tool for generating new insights into the evolution of such traits. Studies capuchin monkeys are particularly well situated to shed light on selective pressures genetic underpinnings local adaptation diverse habitats, longevity, brain development. Distributed widely across Central South America, they inventive extractive foragers, known...
Knowledge on the population history of endangered species is critical for conservation, but whole-genome data chimpanzees (Pan troglodytes) geographically sparse. Here, we produced first non-invasive geolocalized catalog genomic diversity by capturing chromosome 21 from 828 samples collected at 48 sampling sites across Africa. The four recognized subspecies show clear genetic differentiation correlating with known barriers, while previously undescribed exchange suggests that these have been...
Large-scale genomic studies of wild animal populations are often limited by access to high-quality DNA. Although noninvasive samples, such as faeces, can be readily collected, DNA from the sample producers is usually present in low quantities, fragmented, and contaminated microorganism dietary DNAs. Hybridization capture help overcome these impediments increasing proportion subject prior high-throughput sequencing. Here we evaluate a key design variable for hybridization capture, number...
Global biodiversity is rapidly declining due to habitat degradation and genomic erosion, highlighting the urgent need monitor endangered species their genetic health. Temporal genomics ecological modelling offer finer resolution than single-time-point measurements, providing a comprehensive view of species’ recent future trajectories. We investigated erosion environmental suitability in critically regent honeyeater ( Anthochaera phrygia ) by sequencing whole genomes historical modern...
Loss of genetic diversity threatens species survival, yet the dynamics such loss and species′ responses thereof can vary widely depending on their evolutionary histories, life-history traits demographic trajectories. Comparative genomics offers a powerful framework to explore genomic erosion across species. Here, we analysed genomes three — Mauritius parakeet, kestrel, pink pigeon that experienced extreme well-documented population bottlenecks. We compared them 36 spanning avian phylogeny,...
Abstract Admixture, the genetic exchange between differentiated populations appears to be common in history of species, but has not yet been comparatively studied across mammals. This limits understanding its mechanisms and potential role mammalian evolution. The authors want summarize current knowledge on admixture non‐human primates, suggest that it is important establish a comparative framework for this phenomenon humans. Genetic observations domesticated mammals their wild counterparts...
Abstract Noninvasive samples as a source of DNA are gaining interest in genomic studies endangered species. However, their complex nature and low endogenous content hamper the recovery good quality data. Target capture has become productive method to enrich fraction noninvasive samples, such faeces, but its sensitivity not yet been extensively studied. Coping with faecal an below 1% is common problem when prior selection from large collection possible. classified unfavourable for target...
In endangered species, low-genetic variation and inbreeding result from recent population declines. Genetic screenings in populations help to assess their vulnerability extinction create informed management actions toward conservation efforts. The leopard, Panthera pardus, is a highly generalist predator with currently eight different subspecies. Yet, genomic data are still lacking for the Critically Endangered Arabian leopard (P. p. nimr). Here, we sequenced whole genome of two leopards...
Abstract How populations adapt to their environment is a fundamental question in biology. Yet we know surprisingly little about this process, especially for endangered species such as non-human great apes. Chimpanzees, our closest living relatives, are particularly interesting because they inhabit diverse habitats, from rainforest woodland-savannah. Whether genetic adaptation facilitates habitat diversity remains unknown, despite having wide implications evolutionary biology and...
The critically endangered western gorillas (
The black rhinoceros (Diceros bicornis L.) is a critically endangered species historically distributed across sub-Saharan Africa. Hunting and habitat disturbance have diminished both its numbers distribution since the 19th century, but poaching crisis in late 20th century drove them to brink of extinction. Genetic genomic assessments can greatly increase our knowledge inform management strategies. However, when has been severely reduced, with extirpation artificial admixture several...
The Xerces Blue ( Glaucopsyche xerces ) is considered to be the first butterfly become extinct in historical times. It was notable for its chalky lavender wings with conspicuous white spots on ventral wings. last individuals were collected their restricted habitat, dunes near Presidio military base San Francisco, 1941. We sequenced genomes of four 80- 100-year-old Blue, and seven one modern specimens closest relative, Silvery lygdamus ). compared these a novel annotated genome...
Abstract SLC22A10 is an orphan transporter with unknown substrates and function. The goal of this study to elucidate its substrate specificity functional characteristics. In contrast orthologs from great apes, human SLC22A10, tagged green fluorescent protein, not expressed on the plasma membrane. Cells expressing ape exhibit significant accumulation estradiol-17β-glucuronide, unlike those SLC22A10. Sequence alignments reveal a proline at position 220 in humans, which leucine apes. Replacing...
Preserving genetic diversity and adaptive potential while avoiding inbreeding depression is crucial for the long-term conservation of natural populations. Despite demographic increases, traces past bottleneck events at genomic level should be carefully considered population management. From this perspective, peninsular Italian wolf a paradigmatic case. After being on brink extinction in late 1960s, wolves rebounded recolonized most peninsula aided by measures, including habitat legal...
Despite showing the greatest primate diversity on planet, genomic studies Amazonian primates show very little representation in literature. With 48 geolocalized high coverage whole genomes from wild uakari monkeys, we present first population-level study platyrrhines using genome data. In a restricted range of Amazon rainforest, eight species (Cacajao genus) have been described and categorized into bald black groups, based phenotypic ecological differences. slight habitat overlap, that...
Modern human contamination is a common problem in ancient DNA studies. We provide evidence that this issue also present studies great apes, which are our closest living relatives, for example noninvasive samples. Here, we simple method to detect short-read sequencing data from different species: HuConTest. demonstrate its feasibility using blood and tissue samples these species. This test particularly useful more complex (such as museum samples) have smaller amounts of endogenous DNA, show here.
Abstract The Xerces Blue (Glaucopsyche xerces) is considered to be the first butterfly become extinct at global scale in historical times. It was notable for its chalky lavender wings with conspicuous white spots on ventral wings. last individuals were collected their restricted habitat, dunes near Presidio military base San Francisco, 1941. We sequenced genomes of four 80 100-year-old Blue, and seven one modern specimens closest relative, Silvery (G. lygdamus). compared these a novel...
Abstract Background Numerous Ebola virus outbreaks have occurred in Equatorial Africa over the past decades. Besides human fatalities, gorillas and chimpanzees also succumbed to fatal virus. The 2004 outbreak at Odzala-Kokoua National Park (Republic of Congo) alone caused a severe decline resident western lowland gorilla ( Gorilla ) population, with 95% mortality rate. Here, we explore immediate genetic impact population. Results Associations survivorship were evaluated by utilizing DNA...
Captive breeding programmes represent the most intensive type of ex situ population management for threatened species. One example is Cuvier's gazelle programme that started in 1975 with only four founding individuals, and after more than decades captivity, a reintroduction effort was undertaken Tunisia 2016, to establish an area historically included within its range. Here, we aim determine genetic consequences this event by assessing diversity founder stock as well their descendants. We...