Aitor Serres‐Armero
A5029976430- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Cleft Lip and Palate Research
- Genomic variations and chromosomal abnormalities
- Genetic and phenotypic traits in livestock
- Animal Diversity and Health Studies
- Craniofacial Disorders and Treatments
- Wildlife Ecology and Conservation
- Bat Biology and Ecology Studies
- dental development and anomalies
- Congenital heart defects research
- Marine animal studies overview
- Identity, Memory, and Therapy
- Hedgehog Signaling Pathway Studies
- Forensic and Genetic Research
- Identification and Quantification in Food
National Human Genome Research Institute
2022-2025
Universitat Pompeu Fabra
2017-2023
Institut de Biologia Evolutiva
2017-2023
Centre for Genomic Regulation
2017
Horse domestication revolutionized warfare and accelerated travel, trade, the geographic expansion of languages. Here, we present largest DNA time series for a non-human organism to date, including genome-scale data from 149 ancient animals 129 genomes (≥1-fold coverage), 87 which are new. This extensive dataset allows us assess modern legacy past equestrian civilizations. We find that two extinct horse lineages existed during early domestication, one at far western (Iberia) other eastern...
Ancient genomics of horse domestication The the was a seminal event in human cultural evolution. Librado et al. obtained genome sequences from 14 horses Bronze and Iron Ages, about 2000 to 4000 years ago, soon after domestication. They identified variants determining coat color genes selected during process. could also see evidence admixture with archaic demography process, which included accumulation deleterious variants. appears have undergone different type process than animals that were...
Species persistence can be influenced by the amount, type, and distribution of diversity across genome, suggesting a potential relationship between historical demography resilience. In this study, we surveyed genetic variation single genomes 240 mammals that compose Zoonomia alignment to evaluate how effective population size (
Abstract Mammalian Y chromosomes are often neglected from genomic analysis. Due to their inherent assembly difficulties, high repeat content, and large ampliconic regions, only a handful of species have chromosome properly characterized. To date, just single human reference quality chromosome, European ancestry, is available due lack accessible methodology. facilitate the such complicated territory, we developed novel strategy sequence native, unamplified flow sorted DNA on MinION nanopore...
Significance Epigenetic estimators of age (known as clocks) allow one to identify interventions that slow or reverse aging. Previous epigenetic clocks only applied species at a time. Here, we describe apply both dogs and humans. These clocks, which measure methylation levels in highly conserved stretches the DNA, promise increase likelihood will have same effect other.
Dog breeding promotes within-group homogeneity through conformation to strict breed standards, while simultaneously driving between-group heterogeneity. There are over 350 recognized dog breeds that provide the foundation for investigating genetic basis of phenotypic diversity. Typically, standard phenotypes such as stature, pelage, and craniofacial structure analyzed association studies. However, analyses limited assayed only, leaving difficult measure subtleties easily overlooked. We...
Whole genome re-sequencing data from dogs and wolves are now commonly used to study how natural artificial selection have shaped the patterns of genetic diversity. Single nucleotide polymorphisms, microsatellites variants in mitochondrial DNA been interrogated for links specific phenotypes or signals domestication. However, copy number variation (CNV), despite its increasingly recognized importance as a contributor phenotypic diversity, has not extensively explored canids.Here, we develop...
Extreme phenotypic diversity, a history of artificial selection, and socioeconomic value make domestic dog breeds compelling subject for genomic research. Copy number variation (CNV) is known to account significant part inter-individual diversity in other systems. However, comprehensive genome-wide study structural as it relates breed-specific phenotypes lacking. We have generated whole genome CNV maps more than 300 canids. Our data set extends the canine landscape 100 breeds, including...
Captive breeding programmes represent the most intensive type of ex situ population management for threatened species. One example is Cuvier's gazelle programme that started in 1975 with only four founding individuals, and after more than decades captivity, a reintroduction effort was undertaken Tunisia 2016, to establish an area historically included within its range. Here, we aim determine genetic consequences this event by assessing diversity founder stock as well their descendants. We...
Abstract Recent advances in long-read sequencing technologies have allowed the generation and curation of more complete genome assemblies, enabling analysis traditionally neglected chromosomes, such as human Y chromosome (chrY). Native DNA was sequenced on a MinION Oxford Nanopore Technologies device to generate assemblies for seven major chrY haplogroups. We analyzed compared enrichment data obtained using two different selective approaches: adaptive sampling flow cytometry sorting. show...
Mammalian Y chromosomes are often neglected from genomic analysis. Due to their inherent assembly difficulties, high repeat content, and large ampliconic regions 1 , only a handful of species have chromosome properly characterized. To date, just single human reference quality chromosome, European ancestry, is available due lack accessible methodology 2–5 . facilitate the such complicated territory, we developed novel strategy sequence native, unamplified flow sorted DNA on MinION nanopore...
Dog breeding promotes within-group homogeneity through conformation to strict breed standards, and also drives between-group heterogeneity in pursuit of characteristic traits. There are over 350 recognized dog breeds that provide the foundation for investigating genetic basis phenotypic diversity. Typically, standard phenotypes such as stature, fur length, craniofacial structure analyzed association studies. However, analyses limited assayed phenotypes, leaving difficult measure subtleties...
Abstract Recent advances in long-read sequencing technologies have allowed the generation and curation of more complete genome assemblies, enabling analysis traditionally neglected chromosomes, such as human Y chromosome (chrY). Native DNA was sequenced on a MinION Oxford Nanopore Technologies device to generate assemblies for 7 major chrY haplogroups. We analyzed compared enrichment data obtained using two different selective approaches: adaptive sampling flow cytometry sorting. show that...