A5023516016- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Genetic diversity and population structure
- Veterinary Equine Medical Research
- Insect and Pesticide Research
- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Ruminant Nutrition and Digestive Physiology
- melanin and skin pigmentation
- Sports Performance and Training
- Morphological variations and asymmetry
- Genetics and Plant Breeding
- Effects of Environmental Stressors on Livestock
- Livestock Farming and Management
- Winter Sports Injuries and Performance
- Molecular Biology Techniques and Applications
- Bee Products Chemical Analysis
- Animal Behavior and Welfare Studies
- Wnt/β-catenin signaling in development and cancer
- Mechanics and Biomechanics Studies
- Plant Pathogens and Fungal Diseases
- Skin and Cellular Biology Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Meat and Animal Product Quality
- Plant Physiology and Cultivation Studies
Agroscope
2016-2025
University of Zurich
2024
University of Veterinary Medicine Vienna
2017-2023
University of Bern
2014-2017
Bern University of Applied Sciences
2014-2017
The University of Sydney
2012-2017
Institut für Tier-, Natur- und Umweltethik
2012
BOKU University
2010
Ancient genomics of horse domestication The the was a seminal event in human cultural evolution. Librado et al. obtained genome sequences from 14 horses Bronze and Iron Ages, about 2000 to 4000 years ago, soon after domestication. They identified variants determining coat color genes selected during process. could also see evidence admixture with archaic demography process, which included accumulation deleterious variants. appears have undergone different type process than animals that were...
Significance Yakutia is among the coldest regions in Northern Hemisphere, showing ∼40% of its territory above Arctic Circle. Native horses are particularly adapted to this environment, with body sizes and thick winter coats minimizing heat loss. We sequenced complete genomes two ancient nine present-day Yakutian elucidate their evolutionary origins. find that contemporary population descends from domestic livestock, likely brought by early horse-riders who settled region a few centuries ago....
High-throughput sequencing and single nucleotide polymorphism (SNP) genotyping can be used to infer complex population structures. Fine-scale structure analysis tracing individual ancestry remains one of the major challenges. Based on network theory recent advances in SNP chip technology, we investigated an unsupervised clustering method called Super Paramagnetic Clustering (Spc). When applied whole-genome marker data it identifies natural divisions groups individuals into clusters without...
Network-based approaches are emerging as valuable tools for the analysis of complex genetic structure in wild and captive populations. netview p combines data quality control with construction population networks through mutual k-nearest neighbours thresholds applied to genome-wide SNPs. The program is cross-platform compatible, open-source efficiently operates on ranging from hundreds thousands pipeline was used pedigree simulated (n = 750, SNPs 1279) silver-lipped pearl oysters 415, 1107),...
Livestock conservation practice is changing rapidly in light of policy developments, climate change and diversifying market demands. The last decade has seen a step technology analytical approaches available to define, manage conserve Farm Animal Genomic Resources (FAnGR). However, these rapid changes pose challenges for FAnGR terms technological continuity, capacity integrative methodologies needed fully exploit new, multidimensional data. final conference the ESF program aimed address...
Domestication, breed formation and intensive selection have resulted in divergent cattle breeds that likely exhibit their own genomic signatures. In this study, we used genotypes from 27,612 autosomal single nucleotide polymorphisms to characterize population structure based on 9214 sires representing nine Swiss dairy populations: Brown (BS), Braunvieh (BV), Original (OB), Holstein (HO), Red (RH), Fleckvieh (SF), Simmental (SI), Eringer (ER) Evolèner (EV). Genomic inbreeding (F
Summary We used genotype data from the caprine 50k Illumina BeadChip for assessment of genetic diversity within and between 10 local Swiss goat breeds. Three different cluster methods allowed samples to be assigned respective breed groups, whilst Nera Verzasca Tessin Grey goats could not differentiated each other. The results measures show that Appenzell, Toggenburg, Valais Booted should prioritized in future conservation activities. Furthermore, we examined runs homozygosity ( ROH )...
The identification of quantitative trait loci (QTL) such as height and their underlying causative variants is still challenging often requires large sample sizes. In humans hundreds with small effects control the heritable portion variability. domestic animals, typically only a few comparatively explain major fraction heritability. We investigated at withers in Shetland ponies mapped QTL to ECA 6 by genome-wide association (GWAS) using cohort 48 animals Illumina equine SNP70 BeadChip....
Overlapping runs of homozygosity (ROH islands) shared by the majority a population are hypothesized to be result selection around target locus. In this study we investigated impact for coat color within Noriker horse on autozygosity and ROH patterns. We analyzed overlapping homozygous regions gene content in fragments more than 50% horses. Long-term assortative mating chestnut horses small effective size leopard spotted tobiano resulted higher mean genome-wide coverage (SROH ) range...
Pollination is a key ecosystem service for agricultural systems and Western honey bees, Apis mellifera, are the most important managed pollinators. Major losses of bee colonies reinforced need to take advantage locally adapted subspecies ecotypes buffer populations against various stressors. However, introductions non-native bees from distant lineages likely undermine respective conservation efforts unless reliable cost effective tools can be used identify hybridization. The purpose this...
Intensive artificial and natural selection have shaped substantial variation among European horse breeds. Whereas most equine signature studies employ divergent genetic population structures in order to derive specific inter-breed targets of selection, we screened a total 1476 horses originating from 12 breeds for the loss diversity by runs homozygosity (ROH) utilizing 670,000 single nucleotide polymorphism (SNP) genotyping array. Overlapping homozygous regions (ROH islands) indicating...
Analysis of the Y chromosome is best-established way to reconstruct paternal family history in humans. Here, we applied fine-scaled Y-chromosomal haplotyping horses with biallelic markers and demonstrate potential our approach address ancestry sire lines. We de novo assembled a draft reference male-specific region from Illumina short reads then screened 5.8 million basepairs for variants 130 specimens intensively selected rural breeds nine Przewalski's horses. Among domestic confirmed...
Within the scope of current genetic diversity analyses, population structure and homozygosity measures are independently analyzed interpreted. To enhance analytical power, we combined visualization recently described high-resolution networks with runs (ROH). In this study, demonstrate that approach enabled us to reveal important aspects breeding history Haflinger horse. We collected high-density genotype information 531 horses originating from 7 populations which were involved in formation...
The sample ascertainment bias due to complex population structures remains a major challenge in genome-wide investigations of traits. In this study we derived the high-resolution structure and levels autozygosity 377 Lipizzan horses originating from five different European stud farms utilizing SNP genotype information high density 700 k Affymetrix Axiom™ Equine genotyping array. Scanning genome for overlapping runs homozygosity (ROH) shared by more than 50% horses, identified homozygous...
Abstract Successful honey bee breeding programmes require traits that can be genetically improved by selection. Heritabilities for production, behaviour, and health traits, as well their phenotypic correlations, were estimated in two distinct Swiss Apis mellifera carnica populations based on 9 years of performance records more than decades pedigree information. Breeding values a best linear unbiased prediction (BLUP) approach, taking either queen or worker effects into account. In A. m. ,...
Abstract Background Apple breeding schemes can be improved by using genomic prediction models to forecast the performance of material. The predictive ability these depends on factors like trait genetic architecture, training set size, relatedness selected material set, and validation method used. Alternative genotyping methods such as RADseq complementary data from near-infrared spectroscopy could help improve cost-effectiveness prediction. However, impact alternative approaches beyond...
A cost-effective strategy to increase the density of available markers within a population is sequence small proportion and impute whole-genome data for remaining population. Increased densities typed are advantageous genome-wide association studies (GWAS) genomic predictions.We obtained genotypes 54 602 SNPs (single nucleotide polymorphisms) in 1077 Franches-Montagnes (FM) horses Illumina paired-end sequencing 30 FM 14 Warmblood horses. After variant calling, sequence-derived SNP (~13...
Humans have shaped the population history of horse ever since domestication about 5500 years ago. Comparative analyses Y chromosome can illuminate paternal origin modern breeds. This may also reveal different breeding strategies that led to formation extant Recently, a Y-chromosomal phylogeny horses based on 1.46 Mb male-specific (MSY) was generated. We extended this dataset with 52 samples from five European, two American and seven Asian As in previous study, almost all European fall into...
Melanie Parejoab*, Dora Henriquescd, M. Alice Pintoc, Gabriele Soland-Reckewege & Markus Neuditschkoaa Agroscope, Swiss Bee Research Centre, Bern, Switzerland; b Vetsuisse Faculty, Institute of Health, University c Mountain Polytechnic Bragança, Portugal; d Centre Molecular and Environmental Biology, Minho, Braga, e Apigenix, Twann, Switzerland
Summary Shetland ponies were selected for numerous traits including small stature, strength, hardiness and longevity. Despite the different selection criteria, are well known their stature. We performed a signature analysis genome‐wide SNP s of 75 76 large‐sized horses. Based upon this dataset, we identified on equine chromosome ( ECA ) 1 between 103.8 Mb 108.5 Mb. A total 33 annotated genes located within interval IGF 1R gene at 104.2 ADAMTS 17 105.4 These two to have major impact body...