A5088952266- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Reproductive Physiology in Livestock
- Cancer-related molecular mechanisms research
- Effects of Environmental Stressors on Livestock
- Animal Behavior and Welfare Studies
- Genetics and Plant Breeding
- Ruminant Nutrition and Digestive Physiology
- Milk Quality and Mastitis in Dairy Cows
- Genetic diversity and population structure
- Animal Nutrition and Physiology
- Animal Genetics and Reproduction
- Molecular Biology Techniques and Applications
- Veterinary Equine Medical Research
- Wheat and Barley Genetics and Pathology
- Antimicrobial Peptides and Activities
- Lipid metabolism and biosynthesis
- Aquaculture Nutrition and Growth
- Fish Ecology and Management Studies
- Meat and Animal Product Quality
- Genetic Associations and Epidemiology
- Corporate Governance and Management
- Silkworms and Sericulture Research
- Muscle Physiology and Disorders
- Genomics and Phylogenetic Studies
Kiel University
2016-2025
Institut für Tier-, Natur- und Umweltethik
2010
Technical University of Munich
1996-2005
Bayerische Landesanstalt für Wald und Forstwirtschaft
2002
Virginia Tech
1996-1998
Montana State University
1996
The impact of additive-genetic relationships captured by single nucleotide polymorphisms (SNPs) on the accuracy genomic breeding values (GEBVs) has been demonstrated, but recent studies data obtained from Holstein populations have ignored this fact. However, and GEBVs due to linkage disequilibrium (LD), which is fairly persistent over generations, must be known implement future programs. set used investigate these questions consisted 3,863 German bulls genotyped for 54,001 SNPs, their...
DGAT1 encodes diacylglycerol O -acyltransferase (EC 2.3.1.20 ), a microsomal enzyme that catalyzes the final step of triglyceride synthesis. It became functional candidate gene for lactation traits after studies indicated mice lacking both copies are completely devoid milk secretion, most likely because deficient synthesis in mammary gland. Our mapping placed close to region quantitative trait locus (QTL) on bovine chromosome 14 variation fat content milk. Sequencing from pooled DNA revealed...
Abstract Quantitative trait loci (QTL) affecting milk production and health of dairy cattle were mapped in a very large Holstein granddaughter design. The analysis included 1794 sons 14 sires 206 genetic markers distributed across all 29 autosomes flanking an estimated 2497 autosomal cM using Kosambi's mapping function. All families analyzed jointly with least-squares (LS) variance components (VC) methods. A total 6 QTL exceeding approximate experiment-wise significance thresholds, 24...
Various QTL mapping experiments led to the detection of a in centromeric region cattle chromosome 14 that had major effect on fat content milk. Recently, gene encoding diacylglycerol O-acyltransferase (DGAT1) was proposed be positional and functional candidate for this trait. This study investigated effects nonconservative lysine alanine (K232A) substitution DGAT1, which very likely represents causal mutation, milk production traits. Existing granddaughter designs Fleckvieh German Holstein,...
Summary Intramuscular fat content, also assessed as marbling of meat, represents an important beef quality trait. Recent work has mapped a quantitative trait locus (QTL) with effect on to the centromeric region bovine chromosome 14, gene encoding thyroglobulin ( TG ) being proposed positional and functional candidate for this QTL. Recently, diacylglycerol O ‐acyltransferase DGAT1) , which been within QTL, demonstrated affect content milk. In present study, effects 5′‐polymorphism...
This study presents a second generation of linkage disequilibrium (LD) map statistics for the whole genome Holstein-Friesian population, which has four times higher resolution compared with that maps available so far. We used DNA samples 810 German cattle genotyped by Illumina Bovine SNP50K BeadChip to analyse LD structure. A panel 40 854 (75.6%) markers was included in final analysis. The pairwise r(2) statistic SNPs up 5 Mb apart across estimated. mean value = 0.30 +/- 0.32 observed...
The data from the newly available 50 K SNP chip was used for tagging genome-wide footprints of positive selection in Holstein-Friesian cattle. For this purpose, we employed recently described Extended Haplotype Homozygosity test, which detects by measuring characteristics haplotypes within a single population. To assess formally significance these results, compared combination frequency and Relative value each core haplotype with equally frequent across genome. A subset putative regions...
'Selection signatures' delimit regions of the genome that are, or have been, functionally important and therefore been under either natural artificial selection. In this study, two different complementary methods--integrated Haplotype Homozygosity Score (|iHS|) population differentiation index (FST)--were applied to identify traces decades intensive selection for traits economic importance in modern cattle.We scanned a diverse set dairy beef breeds from Germany, Canada Australia genotyped...
Ketosis is a common metabolic disease in dairy cows. Diagnostic markers for ketosis such as acetone and beta-hydroxybutyric acid (BHBA) are known, but prediction remains an unsolved challenge. Milk steadily available biofluid routinely collected on daily basis. This high availability makes milk superior to blood or urine samples diagnostic purposes. In this contribution, we show that glycerophosphocholine (GPC) levels ratios of GPC phosphocholine (PC) allow the reliable selection healthy...
The purpose of this work was to study the impact both size genomic reference populations and inclusion a residual polygenic effect on dairy cattle genetic evaluations enhanced with information. Direct values were estimated for German Holstein BLUP model including effect. A total 17,429 genotyped bulls evaluated using phenotypes 44 traits. Interbull validation test implemented investigate how impacted breeding values. As number increased, variance estimates single nucleotide polymorphism...
A genome-wide association scan for loci affecting withers height was conducted in 782 German Warmblood stallions, which were genotyped using the Illumina EquineSNP50 Bead Chip. principal components approach applied to correct population structure. The analysis revealed a single major QTL on ECA3 explaining ~18 per cent of phenotypic variance, is concordance with recent reports from other horse populations. LCORL/NCAPG locus represents strong candidate gene this QTL. This among small number...
To date, genome-scale analyses in the domestic horse have been limited by suboptimal single nucleotide polymorphism (SNP) density and uneven genomic coverage of current SNP genotyping arrays. The recent availability whole genome sequences has created opportunity to develop a next generation, high-density equine array. Using sequence from 153 individuals representing 24 distinct breeds collated genomics community, we cataloged over 23 million de novo discovered genetic variants. Leveraging...
Abstract A quantitative trait locus (QTL) for milk fat percentage has been mapped consistently to the centromeric region of bovine chromosome 14 (BTA14). Two independent studies have identified nonconservative mutation K232A in acylCoA-diacylglycerol-acyltransferase 1 (DGAT1) gene as likely be causal observed variation. Here we provide evidence additional genetic variability at same QTL that is associated with variation within German Holstein population. Namely, show alleles DGAT1 promoter...
Milk composition traits exhibit a complex genetic architecture with small number of major quantitative trait loci (QTL) explaining large fraction the variation and numerous QTL minor effects. In order to identify for milk fat percentage (FP) in German Holstein-Friesian (HF) population, genome-wide association study (GWAS) was performed. The population consisted 2327 progeny-tested bulls. Genotypes were available 44,280 SNPs. Phenotypes form estimated breeding values (EBVs) FP used as highly...
Recently, artificial neural networks (ANN) have been proposed as promising machines for marker-based genomic predictions of complex traits in animal and plant breeding. ANN are universal approximators functions, that can capture cryptic relationships between SNPs (single nucleotide polymorphisms) phenotypic values without the need explicitly defining a genetic model. This concept is attractive high-dimensional noisy data, especially when architecture trait unknown. However, properties...
Summary The objective of this work was to integrate findings from functional genomics studies with genome‐wide association for fertility and production traits in dairy cattle. Association analyses SNPs located within or close 170 candidate genes derived two gene expression the literature were performed. Data 2294 Holstein bulls genotyped 39557 used. A total 111 on chromosomal segments covered by a gene. Allele substitution effects each SNP estimated using mixed model fixed effect marker...
The molecular regulation of horn growth in ruminants is still poorly understood. To investigate this process, we collected 1019 hornless (polled) animals from different cattle breeds. High-density SNP genotyping confirmed the presence two polled associated haplotypes Simmental and Holstein co-localized on BTA 1. We refined critical region mutation to 212 kb identified an overlapping 932 containing mutation. Subsequently, whole genome sequencing cows was used determine genomic variants. By...
The study of selection signatures helps to find genomic regions that have been under selective pressure and might host genes or variants modulate important phenotypes. Such knowledge improves our understanding how breeding programmes shaped the genomes livestock. In this study, 942 stallions were included from four, exemplarily chosen, German warmblood breeds with divergent historical recent focus different crossbreeding policies: Trakehner (N = 44), Holsteiner 358), Hanoverian 319)...