A5041492104- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Antibiotic Resistance in Bacteria
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Animal Genetics and Reproduction
- Adipose Tissue and Metabolism
- Meat and Animal Product Quality
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Pharmaceutical and Antibiotic Environmental Impacts
- Enterobacteriaceae and Cronobacter Research
- Animal Nutrition and Physiology
- RNA modifications and cancer
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Probiotics and Fermented Foods
- Livestock and Poultry Management
- Bacterial Identification and Susceptibility Testing
- Effects of Environmental Stressors on Livestock
- RNA Research and Splicing
- Environmental DNA in Biodiversity Studies
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
Centre for Research in Anthropology
2018-2025
University of Lisbon
2016-2025
University of Évora
2023-2025
Association for the Development of Douro Viticulture
2024
Institute of Mediterranean and Oriental Cultures
2024
Instituto de Medicina Molecular João Lobo Antunes
2014
Universitatea Andrei Şaguna
2013
Wageningen University & Research
2007-2011
Centre for BioSystems Genomics
2009
The dissection of complex traits economic importance to the pig industry requires availability a significant number genetic markers, such as single nucleotide polymorphisms (SNPs). This study was conducted discover several hundreds thousands porcine SNPs using next generation sequencing technologies and use these SNPs, well others from different public sources, design high-density SNP genotyping assay.A total 19 reduced representation libraries derived four swine breeds (Duroc, Landrace,...
Abstract Linkage disequilibrium (LD) may reveal much about domestication and breed history. An investigation was conducted, to analyze the extent of LD, haploblock partitioning, haplotype diversity within haploblocks across several pig breeds from China Europe in European wild boar. In total, 371 single-nucleotide-polymorphisms located three genomic regions were genotyped. The LD differed significantly between Chinese breeds, extending up 2 cM 0.05 China. extended over large 400 kb, whereas...
Background Artificial selection has caused rapid evolution in domesticated species. The identification of footprints across genomes can contribute to uncover the genetic basis phenotypic diversity. Methodology/Main Findings Genome wide pig domestication and were identified using massive parallel sequencing pooled reduced representation libraries (RRL) representing ∼2% genome from wild boar four domestic breeds (Large White, Landrace, Duroc Pietrain) which have been under strong for muscle...
Livestock conservation practice is changing rapidly in light of policy developments, climate change and diversifying market demands. The last decade has seen a step technology analytical approaches available to define, manage conserve Farm Animal Genomic Resources (FAnGR). However, these rapid changes pose challenges for FAnGR terms technological continuity, capacity integrative methodologies needed fully exploit new, multidimensional data. final conference the ESF program aimed address...
Abstract Standardised analysis pipelines are an important part of FAIR bioinformatics research. Over the last decade, there has been a notable shift from point-and-click pipeline solutions such as Galaxy towards command-line Nextflow and Snakemake. We report on recent developments in nf-core frameworks that have led to widespread adoption across many scientific communities. describe how adopting standards enables faster development, improved interoperability, collaboration with >8,000...
Background Carbapenem-resistant Acinetobacter baumannii is a common pathogen associated with healthcare-acquired infections, and robust infection prevention control protocols exist in human healthcare settings. In contrast, (IPC) standards are limited Veterinary Medicine, necessitating further investigation. Aim Examine the possible transmission of carbapenem-resistant spp. veterinary practice where cat was diagnosed an OXA-23-producing ST2 strain. Methods Environmental samples together...
Although the Illumina 1 G Genome Analyzer generates billions of base pairs sequence data, challenges arise in selection due to varying quality. Therefore, framework International Porcine SNP Chip Consortium, this pilot study aimed evaluate impact quality level sequenced bases on mapping and identification true SNPs a large scale. DNA pooled from five animals commercial boar line was digested with Dra I; 150–250-bp fragments were isolated end-sequenced using Analyzer, yielding 70,348,064...
A Tetralogia de Fallot (TF) é uma cardiopatia congênita complexa que frequentemente requer intervenções precoces para evitar complicações graves. estenose da via saída do ventrículo direito (VSVD) das principais características dessa condição e pode exigir tratamentos paliativos antes cirurgia definitiva. O uso stents na VSVD tem se mostrado estratégia promissora o alívio imediato obstrução melhoria oxigenação nos pacientes, especialmente em casos com alta gravidade risco cirúrgico. Este...
Intensive medical care provided in companion animal practices carries the potential risk of selecting and disseminating multidrug-resistant organisms (MDROs). However, data on infection, prevention control standards specific to small veterinary (SAVPs) remains limited. The goal our work was evaluate environmental contamination staff carriage by MDROs across Portugal. Fourteen SAVPs were enrolled. Environmental samples collected from critical areas such as operating room, wards pre-operative...
An increase in
Este artigo revisa a literatura científica sobre o tratamento atual da atresia de vias biliares (AVB) em pacientes pediátricos, abordando desde os métodos diagnósticos até as opções terapêuticas e resultados longo prazo. A é uma patologia rara, mas grave, que compromete drenagem biliar, levando à insuficiência hepática progressiva. O precoce considerado um dos principais determinantes evolução clínica desses pacientes. cirurgia Kasai intervenção padrão, visando restabelecer nem todos...
Background The emergence of colistin resistance is a One Health antimicrobial challenge worldwide. close contact between companion animals and humans creates opportunities for transmission dissemination colistin-resistant bacteria. Aim To detect potential animal reservoirs Escherichia coli investigate the possible sharing these bacteria dogs, cats their cohabiting in community Lisbon, Portugal. Methods A prospective longitudinal study was performed from 2018 to 2020. Faecal samples dogs...
The identification of cardiac cells with stem cell properties changed the paradigm heart as a post mitotic organ. These proliferate and differentiate into cardiomyocytes, endothelial vascular smooth muscle cells, providing for homeostasis regeneration. microRNAs are master switches controlling proliferation differentiation, in particular regulating biology development. Modulation -regulated gene expression networks holds potential to control fate proliferation, predictable biotechnologic...
The contribution of the decline in thymic activity for emergence autoimmunity is still debatable. Immune-competent adults submitted to complete thymectomy early life provide a unique model address this question. We applied here strict criteria identify lacking based on sjTREC levels, exclude rebound and/or ectopic thymuses. In agreement, they featured severe naïve CD4 T-cell depletion and contraction receptor diversity. Notwithstanding this, there was neither increased incidence autoimmune...
RNA-sequencing (RNA-seq) is rapidly emerging as the technology of choice for whole-transcriptome studies. However, RNA-seq not a bias free technique. It requires large amounts RNA and library preparation can introduce multiple artifacts, compounded by problems from later stages in process. Nevertheless, increasingly used studies, including characterization tissue-specific transcriptomes invertebrate models human disease. The generation samples this context complex, involving establishment...
A successful outcome of a post-surgical wound infection management by carbapenem-resistant Klebsiella pneumoniae is described in dog. Four multidrug-resistant and Escherichia coli strains belonging to ST410 (n = 1) ST648 3) were isolated from faecal samples nasal swabs this dog at admission veterinary hospital the United Kingdom, one month after discharge. Whole-genome sequencing analysis suggests dissemination 46,161-bp IncX3 bla
Antimicrobial resistance mediated by extended-spectrum beta-lactamase (ESBL)- and plasmid-mediated cephalosporinase (AmpC)-producing Enterobacterales, as well carbapenemase-producing Enterobacterales have globally increased among companion animals, posing a potential health risk to humans in contact with them. This prospective longitudinal study investigates the transfer of ESBL/AmpC- between animals their cohabitant Portugal (PT) United Kingdom (UK) during animal infection. Fecal samples...
This study investigated how gene expression is affected by dietary fatty acids (FA) using pigs as a reliable model for studying human diseases that involve lipid metabolism. includes changes in FA composition the liver, blood serum parameters and overall metabolic pathways. RNA-Seq data from 32 were analyzed Weighted Gene Co-expression Network Analysis (WGCNA). Our aim was to identify between diets containing 3% soybean oil (SOY3.0) standard pig production diet 1.5% (SOY1.5). Significantly,...