Qasim Ayub
A5016296408- Forensic and Genetic Research
- Genetic diversity and population structure
- Genetic Associations and Epidemiology
- Genomics and Phylogenetic Studies
- Race, Genetics, and Society
- Genomics and Rare Diseases
- Antibiotic Resistance in Bacteria
- Yersinia bacterium, plague, ectoparasites research
- T-cell and B-cell Immunology
- Forensic Anthropology and Bioarchaeology Studies
- Genomic variations and chromosomal abnormalities
- Vibrio bacteria research studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Molecular Biology Techniques and Applications
- Chromosomal and Genetic Variations
- Genetics and Neurodevelopmental Disorders
- Digestive system and related health
- Child Development and Digital Technology
- Evolution and Genetic Dynamics
- Gut microbiota and health
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- High Altitude and Hypoxia
- Escherichia coli research studies
- Rangeland Management and Livestock Ecology
Monash University Malaysia
2018-2025
Wellcome Sanger Institute
2014-2023
University of California, Santa Cruz
2022
University of Science and Technology Bannu
2022
University of Karachi
2008-2009
Institute of Biomedical and Genetic Engineering
1998-2007
University of Oxford
2000-2003
Defective Gene Detective Identifying genes that give rise to diseases is one of the major goals sequencing human genomes. However, putative loss-of-function genes, which are often some first identified targets genome and exome sequencing, have turned out be errors rather than true genetic variants. In order identify scope within genome, MacArthur et al. (p. 823 ; see Perspective by Quintana-Murci ) extensively validated genomes from 1000 Genomes Project, as well an additional European...
Gorillas are humans' closest living relatives after chimpanzees, and of comparable importance for the study human origins evolution. Here we present assembly analysis a genome sequence western lowland gorilla, compare whole genomes all extant great ape genera. We propose synthesis genetic fossil evidence consistent with placing human–chimpanzee human–chimpanzee–gorilla speciation events at approximately 6 10 million years ago. In 30% genome, gorilla is closer to or chimpanzee than latter...
Genomes from around the globe Genomic sequencing of diverse human populations to understand overall genetic diversity has lagged behind in-depth examination specific populations. To add our understanding diversity, Bergström et al. generated whole-genome sequences surveying individuals in Human Genome Diversity Project, which is a panel global that been instrumental history The authors' study adds data about African, Oceanian, and Amerindian indicates tends result differences at...
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, date the Y-chromosomal most recent common ancestor (MRCA) Africa at 254 (95% CI 192–307) kya and detect cluster major founder haplogroups narrow time interval 47–52 kya,...
Genomes in the mist The mountain gorilla is an iconic species that at high risk of extinction. Xue et al. have sequenced 13 gorillas from two different populations to probe their genetic diversity. genomes show large tracts homozygosity and loss highly deleterious variants, indicating population bottlenecks inbreeding. This diversity appears started over 20,000 years ago may been caused by changes climate human-associated effects. Science , this issue p. 242
We have assessed the numbers of potentially deleterious variants in genomes apparently healthy humans by using (1) low-coverage whole-genome sequence data from 179 individuals 1000 Genomes Pilot Project and (2) current predictions databases variants. Each individual carried 281–515 missense substitutions, 40–85 which were homozygous, predicted to be highly damaging. They also 40–110 classified Human Gene Mutation Database (HGMD) as disease-causing mutations (DMs), 3–24 homozygous state, many...
Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used testing close paternal relationships among individuals and populations, male lineage identification. However, even the widely 17-loci Yfiler set cannot resolve populations completely. Here, 52 centers generated quality-controlled data 13 rapidly mutating (RM) Y-STRs in 14,644 related unrelated males from 111 worldwide populations. Strikingly, >99% 12,272 were completely individualized....
We have identified variants present in high-coverage complete sequences of 36 diverse human Y chromosomes from Africa, Europe, South Asia, East and the Americas, representing eight major haplogroups. After restricting our analysis to 8.97 Mb unique male-specific sequence, we 6662 high-confidence variants, including single-nucleotide polymorphisms (SNPs), multi-nucleotide (MNPs), indels. constructed phylogenetic trees using these or subsets them, recapitulated known structure tree. Assuming a...
The Americas were the last inhabitable continents to be occupied by humans, with a growing multidisciplinary consensus for entry 15-25 thousand years ago (kya) from northeast Asia via former Beringia land bridge [1-4]. Autosomal DNA analyses have dated separation of Native American ancestors Asian gene pool 23 kya or later [5, 6] and mtDNA ∼25 [7], followed isolation ("Beringian Standstill" [8, 9]) 2.4-9 ky then rapid expansion throughout Americas. Here, we present calibrated sequence-based...
1.33 Mb of sequence from the human Y chromosome was searched for tri- to hexanucleotide microsatellites. Twenty loci containing a stretch eight or more repeat units with complete homogeneity were found, 18 which novel. Six (one tri-, four tetra- and one pentanucleotide) assembled into single multiplex reaction their degree polymorphism investigated in sample 278 males Pakistan. Diversities individual ranged 0.064 0.727 Pakistan, while haplotype diversity 0.971. One population, Hazara,...
We have investigated human male demographic history using 590 males from 51 populations in the Human Genome Diversity Project - Centre d'Étude du Polymorphisme Humain worldwide panel, typed with 37 Y-chromosomal Single Nucleotide Polymorphisms and 65 Short Tandem Repeats analyzed program Bayesian Analysis of Trees With Internal Node Generation. The general patterns we observe show a gradient oldest population time to most recent common ancestors (TMRCAs) expansion times together largest...
Population differentiation has proved to be effective for identifying loci under geographically localized positive selection, and the potential identify subject balancing selection. We have previously investigated pattern of genetic among human populations at 36.8 million genomic variants sites in genome showing high frequency differences. Here, we extend this dataset include additional variants, survey with low levels differentiation, evaluate extent which highly differentiated are likely...
Australia was one of the earliest regions outside Africa to be colonized by fully modern humans, with archaeological evidence for human presence 47,000 years ago (47 kya) widely accepted [1, 2]. However, extent subsequent entry before European colonial age is less clear. The dingo reached about 4 kya, indirectly implying contact, which some have linked changes in language and stone tool technology suggest substantial cultural at same time [3]. Genetic data two kinds been proposed support...