A5056919422- Cancer-related Molecular Pathways
- Hearing, Cochlea, Tinnitus, Genetics
- Ferroptosis and cancer prognosis
- Vestibular and auditory disorders
- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Hearing Loss and Rehabilitation
- Molecular Biology Techniques and Applications
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Macrophage Migration Inhibitory Factor
- Head and Neck Cancer Studies
- Breast Lesions and Carcinomas
- Therapeutic Uses of Natural Elements
- Advanced Breast Cancer Therapies
- Sexual Differentiation and Disorders
- Noise Effects and Management
- Acupuncture Treatment Research Studies
- Renal function and acid-base balance
- Phonocardiography and Auscultation Techniques
Beijing Proteome Research Center
2024-2025
University of Nebraska at Omaha
2025
Shaanxi Normal University
2025
Shenyang Agricultural University
2025
Dalian Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
University of Nebraska Medical Center
2025
Army Medical University
2025
Lanzhou University
2020-2024
The repression of repetitive elements is an important facet p53's function as a guardian the genome. Paradoxically, we found that p53 activated by MDM2 inhibitors induced expression endogenous retroviruses (ERV) via increased occupancy on ERV promoters and inhibition two major repressors, histone demethylase LSD1 DNA methyltransferase DNMT1. Double-stranded RNA stress caused ERVs triggered type I/III interferon antigen processing presentation. Pharmacologic activation in vivo unleashed IFN...
The purpose of this study was to explore the effect Semaglutide on intrauterine adhesions and discover new drugs for such adhesions. In study, cell model simulated by TGF-β1-induced human endometrial epithelial cells, animal established through mechanical curettage inflammatory stimulation. After co-culturing with TGF-β1 or without different concentrations 48 h, cells were collected RT-qPCR Western blotting analyses. Three doses subcutaneously injected into experimental mice once a day two...
Early identification and treatment of ventricular remodeling (VR) are crucial for delaying the progression heart failure after myocardial infarction. This study aims to develop a dual-responsive phase-shift molecular probe loaded with cholecystokinin octapeptide (CCK-8) oxygen, which will provide new integrated scheme assessment VR. Biocompatible phospholipid shells were utilized encapsulate CCK-8 perfluoropentane (PFP), an efficient oxygen carrier. Surface modification involves reactive...
122 Background: Androgen deprivation therapy (ADT) is essential for management of advanced prostate cancer, yet it carries risks including osteoporosis and fragility fractures. Antiresorptive recommended to reduce fractures patients at high risk. However, precisely which should undergo formal screening with dual-energy X-ray absorptiometry (DEXA) baseline has been relatively unexplored. This study aims describe these fracture risks, the utility DEXA based upon Fracture Risk Assessment Tool...
Chemoprevention is key in managing actinic keratoses and preventing the development of skin cancer, especially individuals with cutaneous field cancerization [1]. Treatments including topical agents (5-fluorouracil [5-FU] imiquimod), oral medications (niacinamide acitretin), light therapies like photodynamic therapy (PDT) target keratinocyte changes contiguous areas However, patient adherence to these remains challenging, often due bothersome reactions [2]. This study assesses discrepancy...
Breast cancer (BC) is the most common gynecologic tumor worldwide where aberrant expression of microRNAs (miRNAs) frequently involved. Here, we evaluated function miR-375 on BC development and molecules implicated. Differentially expressed genes between paired normal tissues from patients were screened out by microarray analyses. was abundantly in cells, it correlated with poor prognosis patients. Downregulation introduced into cell lines MCF-7 HCC1954, after which viability, colony...
Abstract Combined effect of cigarette smoking and occupational noise exposure on hearing loss has rarely been evaluated among Chinese population, especially females. This cross-sectional study was conducted in 11196 participants Dongfeng-Tongji cohort study. Smoking status self-reported through questionnaire workplace level and/or the job titles. Hearing defined as a pure-tone mean 25 dB or higher at 0.5, 1, 2, 4 kHz both ears. Compared with without exposure, risk significantly for duration...
p53 mutants contribute to the chronic inflammatory tumour microenvironment (TME). In this study, we address mechanism of how lead inflammation in tumours and transform it restore cancer immune surveillance.Our analysis RNA-seq data from The Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) project revealed that mutant (mtp53) cancers correlated with inflammation. We used cell-based assays a mouse model discover novel gain function mtp53 effect reactivating compound APR-246 on...
Background: Although the association of metabolic syndrome (MetS) and hearing loss has been evaluated, findings are controversial. This study investigated this in a Chinese population.Methods: A cross-sectional including total 18,824 middle-aged older participants from Dongfeng-Tongji Cohort was conducted. Hearing defined as pure-tone average (PTA) frequencies 0.5, 1.0, 2.0, 4.0 kHz >25 decibels level (dB HL) better ear graded mild (PTA 26–40 dB HL), moderate >40 to ≤60 severe >60 HL). MetS...
Demonstrated here is the use of metal free system in a three component fluoroalkylfluoroalkylselenolation alkenes under visible light irradiation. The method combines two photoinduced process and allows introduction –R<sub>f</sub> –SeR<sub>f</sub> to alkenes.
Abstract Background Gastric cancer is one of the most common malignant tumors digestive system. However, its targeted therapy develops at a slow pace. Thus, exploring mechanisms behavior gastric cells crucial to exploit treatment. Mammalian never-in-mitosis A (NIMA)-related kinases (NEKs) are considered play significant role in cell proliferation. no study has reported on NIMA family proteins cancer. Methods Bioinformatics analysis was employed clarify expression patterns NEK1–NEK11 and...
To investigate the prevalence of
Abstract Perifosine, an Akt inhibitor, has been shown to be effective in controlling neuroblastoma tumor growth. However, studies indicate that addition the ability inhibit Akt, other mechanisms contribute perifosine’s anti-tumor activity. To gain insight into perifosine activity we have studied changes proteome and acetylome after treatment SK-N-AS cells using SILAC labeling, affinity enrichment, high-resolution LC-MS/MS analysis. Bioinformatic analysis indicates that, a total of 5,880...
This paper aimed to analyze the clinicopathological characteristics of invasive ductal carcinoma with an micropapillary component (IDC + IMPC), a in situ DCIS), and compare prognosis those IDC.A total 1713 patients (130 IDC IMPC cases, 352 DCIS 1231 pure cases) who underwent appropriate surgery from June 2011 September 2017 were retrospectively selected.Compared patients, presented more aggressive characteristics, such as higher proportion vascular invasion (P < .001), fewer progesterone...
Abstract Reactivation of p53 tumor-suppressor function by small molecules is an attractive strategy to defeat cancer. A potent p53-reactivating molecule RITA, which triggers p53-dependent apoptosis in human tumor cells vitro and vivo, exhibits p53-independent cytotoxicity due modifications detoxification enzyme Sulfotransferase 1A1 (SULT1A1), producing a reactive carbocation. Several synthetic RITA's heterocyclic scaffold lead higher energy barriers for carbocation formation. In this study,...
Objective To determine whether aldehyde dehydrogenase 1 (ALDH1) immunostaining in axillary lymph node metastases patients with breast cancer is associated poor clinical prognosis. Methods This retrospective study reviewed data from the medical records of immunohistochemistry-confirmed invasive ductal carcinoma (IDC) and 1–3 metastatic nodes ipsilateral axilla between December 2012 July 2015. The association ALDH1 parameters prognosis was analysed using χ 2 -test, Kaplan–Meier survival...