A5100672465- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Cholesterol and Lipid Metabolism
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Cancer-related molecular mechanisms research
- Veterinary medicine and infectious diseases
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Cancer Risks and Factors
- Extracellular vesicles in disease
- Esophageal Cancer Research and Treatment
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
- Chromium effects and bioremediation
- Cancer Mechanisms and Therapy
- Gastrointestinal disorders and treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Heavy Metal Exposure and Toxicity
- Oral health in cancer treatment
- Cancer, Stress, Anesthesia, and Immune Response
First Hospital of Lanzhou University
2011-2025
Lanzhou University
2016-2025
Institute of Hematology & Blood Diseases Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Ministry of Natural Resources
2022
Chinese Academy of Geological Sciences
2022
Abstract Some lactobacilli have protective effects against some heavy metals in mammals, but the underlying mechanism is not fully understood. To evaluate remediation potency and of Lactobacillus chromium (Cr) mice, plantarum TW1-1 was orally administrated to Kunming mice for 7 weeks during exposure 1 mM K 2 Cr O drinking water. Results showed that helped decrease accumulation tissues increase excretion feces, may also attenuate alterations oxidative stress histopathological changes caused...
Background: To date, the pathogenesis of gastric cancer (GC) remains unclear.We combined public database resources and bioinformatics analysis methods, explored some novel genes verified experiments to further understand GC provide a promising target for anti-tumor therapy. Methods:We downloaded chip data related from Gene Expression Omnibus (GEO) database, extracted differentially expressed (DEGs), then determined key in development via PPI networks model analysis.Functional annotation GO...
Objective: To investigate the effect of ten-eleven translocation methylcytosine dioxygenase 2 (TET2) gene mutations on secondary myelofibrosis (SMF) JAK2V617F+ myeloproliferative neoplasms (MPN) patients. Method: A retrospective collection was conducted MPN patients with JAK2V617F mutation detected by second-generation sequencing in Department Hematology, Second Hospital Tianjin Medical University. TET2+JAK2V617F+ were selected as mutant group, and TET2-JAK2V617F+ matched for age gender...
Locally advanced gastric cancer (LAGC) poses a significant surgical challenge. While laparoscopic gastrectomy (LG) offers potential advantages, its cost-effectiveness relative to open (OG) in China remains uncertain. To compare the of LG and OG for LAGC China. A Markov model compared LAGC. Probabilities utilities were derived from published literature. Direct medical costs obtained First Hospital Lanzhou University. The primary outcome was incremental ratio (ICER), expressed as cost per...
Abstract Gastric cancer has become the third most common around world. In patients with gastric cancer, 5‐year survival rate is still low. However, mechanism underlying remains largely unknown. As a glycolytic enzyme, enolase 1 (ENO1) widely expressed in tissues. The functions of ENO1 have been reported various types cancer. Here this study, we identified that promoted growth cells through diverse mechanisms. Our immunohistochemical, bioinformatic and Western blot data showed was...
Abstract Background Gastric cancer is one of the most common malignant tumors digestive system. However, its targeted therapy develops at a slow pace. Thus, exploring mechanisms behavior gastric cells crucial to exploit treatment. Mammalian never-in-mitosis A (NIMA)-related kinases (NEKs) are considered play significant role in cell proliferation. no study has reported on NIMA family proteins cancer. Methods Bioinformatics analysis was employed clarify expression patterns NEK1–NEK11 and...
α-Enolase is a significant subunit of enolase and acts as glycolytic enzyme responsible for catalyzing the conversion 2-phosphoglycerate to phosphoenolpyruvate in anaerobic glycolysis pathway. The research about their role known little tumor invasion metastasis. This analyzed effect α-enolase proliferation progression human gastric cancer. constructed PLKO.1-ENO1 shRNA vector was transfected into 293 T cells used infect cancer cells, MKN45, by using lentivirus method. Negative controls were...
This research investigated the predictive role of metabolic syndrome (MetS) in breast cancer neoadjuvant chemotherapy (BCNACT) response.One hundred fifty primary (BC) patients who underwent (NACT) were included retrospectively. MetS, MetS components [waist circumference (WC), fasting blood glucose (FBG), pressure, triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C)], serum lipid, other MetS-related laboratory indicators within two weeks before BCNACT evaluated. Univariate,...
Our study aims to detect the sensitivity of new biomarker miR-212 existing in serum exosomes along with other hepatocellular carcinoma biomarkers such as AFP (alpha-fetoprotein), CA125 (carbohydrate antigen-ca125), and Hbx protein diagnosis HBV-related liver diseases. We also aim roles these progression chronic hepatitis B provide scientific data show clinical value biomarkers.We selected 200 patients HBV-infection (58 cases B, 47 carcinoma, 30 compensatory phase cirrhosis, 65 decompensatory...
Gastric cancer has been the second cause of death worldwide. Chemical comprehensive treatment programs primarily were main therapy method with modest efficacy to gastric cancer. Traditional Chinese medicine (TCM) reported alleviate adverse events induced by chemotherapy, but not yet developed clinical trials test and needs scientific evidence for making policy. Single-patient (N-of-1) might be an eligible study design TCM since it well represented individualized philosophy TCM. The aim this...