A5015710368- RNA and protein synthesis mechanisms
- Landslides and related hazards
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Fungal and yeast genetics research
- Gastric Cancer Management and Outcomes
- Hydrology and Sediment Transport Processes
- Genomics and Phylogenetic Studies
- Machine Learning in Bioinformatics
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Fire effects on ecosystems
- Flood Risk Assessment and Management
- Ferroptosis and cancer prognosis
- Protein Structure and Dynamics
- MicroRNA in disease regulation
- Dam Engineering and Safety
- Advanced Proteomics Techniques and Applications
- DNA and Nucleic Acid Chemistry
- RNA Research and Splicing
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Glioma Diagnosis and Treatment
- Advanced Biosensing Techniques and Applications
First Affiliated Hospital of Xi'an Jiaotong University
2023-2025
Second Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Institute of Mountain Hazards and Environment
2022-2024
Chinese Academy of Sciences
2022-2024
University of Chinese Academy of Sciences
2022-2024
The University of Western Australia
2017-2023
Harry Perkins Institute of Medical Research
2023
The University of Queensland
2023
Fiona Stanley Hospital
2017-2023
To facilitate studies of the yeast proteome, we cloned 5800 open reading frames and overexpressed purified their corresponding proteins. The proteins were printed onto slides at high spatial density to form a proteome microarray screened for ability interact with phospholipids. We identified many new calmodulin- phospholipid-interacting proteins; common potential binding motif was calmodulin-binding Thus, microarrays an entire eukaryotic can be prepared diverse biochemical activities. also...
Sickle cell anemia is the most common heritable hematological disease, yet no curative treatment exists for this disorder. Moreover, intricacies of globin gene expression have made development treatments hemoglobinopathies based on therapy difficult. An alternative genetic approach to sickle RNA repair. A trans-splicing group I ribozyme was used alter mutant β-globin transcripts in erythrocyte precursors derived from peripheral blood individuals with disease. were converted into messenger...
Abstract Only about half of non‐membrane‐bound proteins encoded by either bacterial or archaeal genomes are soluble when expressed in Escherichia coli (Yee et al., Proc Natl Acad Sci USA 2002;99:1825–1830 ; Christendat Prog Biophys Mol Biol 200;73:339–345) . This property limits genome‐scale functional and structural proteomics studies, which depend on having a recombinant, version each protein. An emerging strategy to increase the probability deriving derivative protein is study different...
Delivery of large volumes sediment by debris flows in a short time into rivers often initiates hazardous chain reaction alpine valleys. Predicting the multi-hazard chain’s evolution and intervening its cascading effects artificial countermeasures face major challenges due to spatial temporal variability controlling factors. On June 17, 2020, rainstorm-induced flow event with volume 2.4 × 10 5 m 3 occurred Meilong catchment, Danba County, Sichuan Province, Southwest China, which triggered...
The aim of this study was to investigate the impact diabetes on mortality and adverse outcomes in COVID-19 patients analyse associated risk factors. This is a retrospective cohort 500 hospitalized with infection (214 286 without diabetes) admitted tertiary hospital China from December 2022 February 2023. Demographic information, clinical characteristics were collected. Survival status investigated at discharge 6 months after discharge. rate higher than non-diabetic patients, both discharge,...
To observe the current situation of fertility preservation among female breast cancer patients ≤ 40 years old and analyze related factors which influence utilization preservation. A single-center retrospective questionnaire was conducted investigating diagnosed with attending The First Affiliated Hospital Xian JiaoTong University between January 2016 December 2019. redesigned based on previous similar research questions needed in this study. Rates services were compared patients' demographic...
Abstract. Debris flows, as a special kind of landslide, often block rivers to form barrier dams and trigger series disasters such upstream aggradation outburst floods. The understanding debris flow (DFBDs) is poor, mostly due existing studies focusing on individual events lack summarization multiple DFBD events. global or regional datasets landslide (LDs) contain only few cases DFBDs ignore the differences between other (LDs), rock slides, avalanches, earth slides. To fill this gap, we...
Previously we demonstrated that a group I ribozyme can perform trans -splicing to repair sickle β-globin transcripts upon transfection of in vitro transcribed into mammalian cells. Here, sought develop expression cassettes would yield high levels active after gene transfer. Our initial constructs were designed generate -slicing ribozymes identical those used our previous RNA studies with containing 6-nucleotide long internal guide sequences. The expressed from these cassettes, however, found...
Purpose Research on bone metastasis in esophageal cancer (EC) is relatively limited. Once occurs patients, their prognosis poor, and it severely affects quality of life. Currently, there a lack convenient tumor markers for early identification EC. Our research aims to explore whether neutrophil-lymphocyte ratio (NLR) can predict patients with Methods Retrospective analysis clinical indicators was performed 604 They were divided into groups based or not metastasis, the patients’...
Objective: To establish a prediction model based on autophagy-related lncRNAs and investigate the functional enrichment of in colorectal cancer. Methods: TCGA database was used to extract transcriptome data clinical features cancer patients. HADb obtain genes. Pearson correlation analysis performed identify lncRNAs. The with prognostic values were selected. Based selected lncRNAs, risk score nomogram constructed, respectively. Calibration curve, concordance index, ROC curve evaluate...
Recent reports have demonstrated that trans-splicing ribozymes can be employed to repair mutant RNAs. One key factor influences RNA efficiency is the accessibility of substrate for ribozyme binding, which complicated by fact RNAs may assume multiple conformations and proteins bound them in vivo. Here we describe a strategy map accessible sites on sickle β-globin (βs-globin) transcripts vitro vivo use this information enhance efficiency. Two upstream mutation were identified as some fraction...