A5101925522- Epigenetics and DNA Methylation
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Polysaccharides and Plant Cell Walls
- Vestibular and auditory disorders
- DNA Repair Mechanisms
- Hearing Loss and Rehabilitation
- Folate and B Vitamins Research
- RNA Research and Splicing
- Photodynamic Therapy Research Studies
- Cancer-related gene regulation
- Telomeres, Telomerase, and Senescence
- Ferroptosis and cancer prognosis
- Antioxidants, Aging, Portulaca oleracea
- Kruppel-like factors research
- Traditional Chinese Medicine Analysis
- Polysaccharides Composition and Applications
- Nanoplatforms for cancer theranostics
- Sphingolipid Metabolism and Signaling
- Cancer Research and Treatments
- Genetics and Neurodevelopmental Disorders
- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- Bacterial biofilms and quorum sensing
Huazhong University of Science and Technology
2015-2024
Union Hospital
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Hainan Medical College Hospital
2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2024
Wenzhou Medical University
2023
First Affiliated Hospital of Wenzhou Medical University
2023
Shanghai Jiao Tong University
2023
Age-related dysfunction of the central auditory system, also known as presbycusis, can affect speech perception and sound localization. Understanding pathogenesis presbycusis will help to develop novel approaches prevent or treat this disease. In study, mechanisms were investigated using a mimetic aging rat model induced by chronic injection D-galactose (D-Gal). We showed that malondialdehyde (MDA) levels increased manganese superoxide dismutase (SOD2) activity was reduced in cortex natural...
HIV infection related to commercial sexual contact is a serious public health issue in China. The objectives of the present study are explore predictors condom use among female sex workers (FSWs) China and examine relationship between Health Belief Model (HBM) constructs.
To investigate the absorption and delivery of ASP in gastrointestinal (GI) tract, cASP was successfully synthesized by chemically modifying with succinic anhydride then conjugating a near infrared fluorescent dye Cy5.5. Then, capacity oral evaluated. The results demonstrated that had low toxicity no disruption on integrity cell membrane. endocytosis into epithelial cells time- energy-dependent, which mediated macropinocytosis pathway clathrin- caveolae (or lipid raft)-related routes....
Background Aberrant methylation of DNA plays an important role in the pathogenesis nasopharyngeal carcinoma (NPC). In current study, we aimed to integrate three cohorts profile datasets identify abnormally methylated-differentially expressed genes and pathways associated with NPC. Methods Data gene expression microarrays (GSE53819, GSE412452) (GSE52068) obtained from GEO database. Aberrantly methylated differentially (DEGs) were by GEO2R. The David database was utilized perform enrichment...
Abstract Background An increasing number of COVID‐19 patients worldwide will probably need tracheostomy in an emergency or at the recovering stage COVID‐19. We explored safe and effective management patients, to benefit protect health care workers same time. Methods retrospectively analyzed 11 hospitalized undergoing tracheostomy. Clinical features ventilator withdrawal after tracheostomy, surgical complications, nosocomial infection associated with were analyzed. Results The all cases...
Despite advancements in occupational health and safety (OHS) management, high-risk industries China continue to report a significant number of fatal accidents, underscoring systemic challenges protecting the well-being workers while supporting economic development. This study analyzed 22 years historical data on OHS incidents, labor dynamics, growth China's via multiple regression network analysis methods. The findings reveal hierarchical influence relationships, with coal mine fatalities...
The interest in developing new drug carriers for delivery to the liver using natural polysaccharides with a high galactose content has necessitated study of pharmacokinetics and tissue distribution these polysaccharides. In this paper, method was established microanalysis Angelica sinensis polysaccharide (ASP) biosamples. Fluorescein-labelled ASP (FA) rapidly eliminated from bloodstream distributed specificity following intravenous injection. analysis hepatocellular localization demonstrated...
IntroductionCoronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) swept rapidly throughout the world. So far, no therapeutics have yet proven to be effective. Ribavirin was recommended for treatment of COVID-19 in China because its vitro activity. However, evidence supporting clinical use with good efficacy is still lacking.MethodsA total 208 confirmed patients who were hospitalized Wuhan Union West Campus between 1 February 2020 and 10...
Folate plays a pivotal role in DNA synthesis, repair, methylation and homocysteine (Hcy) metabolism. Therefore, alterations the folate-mediated one-carbon metabolism may lead to abnormal proliferation, increases of tumor/neoplasia vein thrombosis/cardiovascular risk. The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), reductase (MTRR) cystathionine beta (CBS) regulate key reactions folate Hcy we investigated whether genetic variants SHMT, MS, MTRR CBS gene can affect plasma...
The detection of all glands during total parathyroidectomy (TPTX) in secondary hyperparathyroidism (SHPT) patients is often difficult due to their variability number and location. objective this study was evaluate the feasibility near-infrared fluorescence (NIRF) imaging using indocyanine green (ICG) for intraoperative parathyroid gland (PTG) localization SHPT patients. Twenty-nine with were divided into two groups or without NIRF imaging. ICG administered undergoing imaging, PTGs assessed....
The tea catechin epigallocatechin-3-gallate (EGCG) proved to be the most potent physiologically active compound in vitro. It possesses antioxidant as well pro-oxidant properties. EGCG has effect of inducing apoptosis tumor cells and inhibiting cell proliferation. Whether this is associated with or pro-oxidative effects affecting genome stability normal cancer not been confirmed. Here, we selected Human colon epithelial NCM460 adenocarcinoma COLO205 investigate (0−40 μg/mL) on growth status....
Folates comprise the essential B9 vitamin that act as cofactors and cosubstrates in one-carbon metabolism for both biosynthesis methylation of DNA RNA. Folate deficiency (FD) has been shown to induce chromosomal instability (CIN), yet underlying mechanisms are poorly understood. Here, we used human NCM460 colon mucosal cells a model investigate effect FD on spindle assembly checkpoint (SAC), cell-cycle regulatory pathway preventing CIN during mitosis. Cells were maintained medium containing...
Photodynamic therapy (PDT) has emerged as a promising locoregional of hepatocellular carcinoma (HCC). The utilization luminogens with aggregation-induced emission (AIE) characteristics provides new opportunity to design functional photosensitizers (PS). PSs targeting the critical organelles that are susceptible reactive oxygen species damage is strategy enhance effectiveness PDT. In this paper, PS, 1-[2-hydroxyethyl]-4-[4-(1,2,2-triphenylvinyl)styryl]pyridinium bromide (TPE-Py-OH)...
Abstract Combined effect of cigarette smoking and occupational noise exposure on hearing loss has rarely been evaluated among Chinese population, especially females. This cross-sectional study was conducted in 11196 participants Dongfeng-Tongji cohort study. Smoking status self-reported through questionnaire workplace level and/or the job titles. Hearing defined as a pure-tone mean 25 dB or higher at 0.5, 1, 2, 4 kHz both ears. Compared with without exposure, risk significantly for duration...
Nasopharyngeal carcinoma (NPC) is the most common malignant tumor with a remarkable racial and geographical distribution including people in southern China, South East Asia, Middle East/North Africa. DNA methylation an important manifestation of epigenetic modification, has been studied over several decades, by regulating controlling expression cancer-related genesits, abnormal can influence variety human malignancy tumors.Until now, there no analysis focus on differentially methylated,...
An AIE-active photosensitizer, <bold>TTVPHE</bold>, can fast penetrate into cancer cells and efficiently trigger mitochondria-dependent apoptotic pathway with self-monitoring ability.
Neurosynovial tumors, originating from Schwann cells within nerve sheaths, are benign entities, with 25% to 45% manifesting in the head and neck region. However, occurrences pterygopalatine fossa (PPF) exceptionally rare, only a handful of cases have been documented. In this report, we present unique case 6-year-old child exhibiting sizable soft tissue mass left PPF, extending into inferior orbital fissure. The patient underwent successful intranasal endoscopic removal PPF schwannoma...
Mobile commerce user experiences are negatively affected by the constraints imposed upon mobile terminals. These constraints, which include small screens, inconvenient input and slow response, will affect usage adoption behaviour. Drawing flow theory, this research examined effect of interactivity on experience. The results indicated that two factors interactivity, namely ubiquitous connectivity contextual offering have significant effects experience, including perceived enjoyment, control...