A5067830245- Hearing, Cochlea, Tinnitus, Genetics
- Plant Molecular Biology Research
- Plant Physiology and Cultivation Studies
- Bone and Dental Protein Studies
- Biochemical Acid Research Studies
- Plant Stress Responses and Tolerance
- Nitric Oxide and Endothelin Effects
- Cleft Lip and Palate Research
- Dermatological and COVID-19 studies
- Biochemical Analysis and Sensing Techniques
- Biochemical effects in animals
- Infection Control and Ventilation
- Oral and Maxillofacial Pathology
- Redox biology and oxidative stress
- Antioxidants, Aging, Portulaca oleracea
- Plant Reproductive Biology
- Chemical Reactions and Isotopes
- Sirtuins and Resveratrol in Medicine
- COVID-19 and healthcare impacts
- Neuroscience and Neuropharmacology Research
- Amino Acid Enzymes and Metabolism
Huazhong University of Science and Technology
2012-2024
Northwest A&F University
2024
Tongji Hospital
2022-2024
Union Hospital
2020
Age-related dysfunction of the central auditory system, also known as presbycusis, can affect speech perception and sound localization. Understanding pathogenesis presbycusis will help to develop novel approaches prevent or treat this disease. In study, mechanisms were investigated using a mimetic aging rat model induced by chronic injection D-galactose (D-Gal). We showed that malondialdehyde (MDA) levels increased manganese superoxide dismutase (SOD2) activity was reduced in cortex natural...
Abstract Bud dormancy is a crucial strategy for perennial plants to withstand adverse winter conditions. However, the regulatory mechanism of bud in tree peony (Paeonia suffruticosa) remains largely unknown. Here, we observed dramatically reduced and increased accumulation abscisic acid (ABA) bioactive gibberellins (GAs) GA1 GA3, respectively, during endodormancy release under prolonged chilling treatment. An Illumina RNA sequencing study was performed identify potential genes involved...
Age‐associated degeneration in the central auditory system, which is defined as presbycusis, can impair sound localization and speech perception. Research has shown that oxidative stress plays a role pathological process of presbycusis. Thioredoxin 2 (Trx2), one member thioredoxin family, key regulating homeostasis cellular reactive oxygen species anti‐apoptosis. The purpose this study was to explore association between Trx2 phenotype presbycusis using mimetic aging animal model induced by...
Bud dormancy is crucial for woody perennial plants to resist low-temperature stress in winter. However, the molecular regulatory mechanisms underlying bud release are largely unclear. Here, a tree peony ( Paeonia suffruticosa ) transcript ARABIDOPSIS TOXICOS EN LEVADURA 33 PsATL33 ), encoding RING-H2 finger protein, was selected from previously generated RNA sequencing data of chilling-treated buds. The objective this study investigate role regulation cold-induced release. Subcellular...
Cholesteatoma is a common disease of the middle ear. Currently, surgical removal only treatment option and patients face high risk relapse. The molecular basis cholesteatoma remains largely unknown. Here, we show that Osteopontin (OPN), predominantly secreted protein, plays crucial role in development ear cholesteatoma. Global transcriptome analysis revealed loss epithelial features an enhanced immune response human tissues. Quantitative RT-PCR immunohistochemical staining validated reduced...
Evaluating auditory sensitivity is critical to hearing research, particularly that focusing on impairment. Auditory brainstem response recording frequently used in mice assess and an approach superior the traditional techniques. Here, we describe a protocol for ABR using four-channel equipment. We detail procedures of animal preparation, setup system, click- tone burst-evoked recordings, data analysis.
To the Editor: Recently, number of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in China has been decreasing. At manuscript preparation, cases had not reported Wuhan since March 18, 2020.1The Novel Coronavirus Pneumonia Emergency Response Epidemiology TeamThe epidemiological characteristics an outbreak 2019 novel diseases (COVID-19) — China, 2020.China CDC Weekly. 2020; 2: 113-122Crossref Scopus (1278) Google Scholar As health care systems resume routine...